Z
Zhigang Wang
Researcher at New York Medical College
Publications - 12
Citations - 921
Zhigang Wang is an academic researcher from New York Medical College. The author has contributed to research in topics: Human leukocyte antigen & Antigen. The author has an hindex of 10, co-authored 12 publications receiving 893 citations. Previous affiliations of Zhigang Wang include Roswell Park Cancer Institute.
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Journal ArticleDOI
Lack of HLA class I antigen expression by cultured melanoma cells FO-1 due to a defect in B2m gene expression.
TL;DR: Results suggest that genetic recombination in the 5' region of the B2m gene is a recurrent mechanism in B1m gene defects, and FO-1 cells represent a useful model for analyzing the role of HLA class I antigens in the biology of melanoma cells and in their interaction with cells of the immune system.
Journal ArticleDOI
beta2-Microglobulin mutations, HLA class I antigen loss, and tumor progression in melanoma.
Daniel J. Hicklin,Zhigang Wang,Flavio Arienti,Licia Rivoltini,Giorgio Parmiani,Soldano Ferrone +5 more
TL;DR: Investigation of mechanisms underlying lack of HLA class I antigen expression by melanoma cell lines Me18105, Me9923, and Me1386 suggests that beta2m mutations in melanoma cells may be an early event in progression to the malignant phenotype.
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Selective Histocompatibility Leukocyte Antigen (Hla)-A2 Loss Caused by Aberrant Pre-mRNA Splicing in 624mel28 Melanoma Cells
TL;DR: The results indicate that a single mutational event in an HLA class I gene is sufficient for loss of the corresponding allele, and emphasizes the need to implement active specific immunotherapy with a combination of peptides presented by various HLAclass I alleles.
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Lack of HLA class I antigen expression by melanoma cells SK-MEL-33 caused by a reading frameshift in beta 2-microglobulin messenger RNA.
TL;DR: The molecular lesion identified in the SK-MEL-33 melanoma cell line is not caused by a mutation acquired during growth in vitro but is likely to reflect a somatic mutation during tumor progression.
Journal Article
Selective loss of human leukocyte class I allospecificities and staining of melanoma cells by monoclonal antibodies recognizing monomorphic determinants of class I human leukocyte antigens.
Toshiro Kageshita,Zhigang Wang,Lido Calorini,Akira Yoshii,Toru Kimura,Tomomichi Ono,Sebastiano Gattoni-Celli,Soldano Ferrone +7 more
TL;DR: The present results provide a mechanism for the unexpected resistance to cytotoxic T-cell-mediated lysis and the unexpected poor clinical course of the disease in some patients despite a high expression of HLA Class I antigens as measured by staining of melanoma cells with mAb to monomorphic determinants.