Z
Zhihu Zhao
Researcher at Uppsala University
Publications - 14
Citations - 1650
Zhihu Zhao is an academic researcher from Uppsala University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 4, co-authored 5 publications receiving 1526 citations.
Papers
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Journal ArticleDOI
Circular chromosome conformation capture (4C) uncovers extensive networks of epigenetically regulated intra-and interchromosomal interactions
Zhihu Zhao,Gholamreza Tavoosidana,Mikael Sjölinder,Anita Göndör,Piero Mariano,Sha Wang,Chandrasekhar Kanduri,Magda Lezcano,Kuljeet Singh Sandhu,Umashankar Singh,Vinod Pant,Vijay K. Tiwari,Sreenivasulu Kurukuti,Rolf Ohlsson +13 more
TL;DR: It is found that the direct interaction between differentially methylated regions was linked to epigenetic regulation of transcription in trans and the patterns of interactions specific to the maternal H19 imprinting control region underwent reprogramming during in vitro maturation of embryonic stem cells.
Journal ArticleDOI
CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2
Sreenivasulu Kurukuti,Vijay K. Tiwari,Gholamreza Tavoosidana,Elena M. Pugacheva,Adele Murrell,Zhihu Zhao,Victor V. Lobanenkov,Wolf Reik,Rolf Ohlsson +8 more
TL;DR: Systematic chromosome conformation capture analysis of an imprinting cluster reveals that CTCF has a critical role in the epigenetic regulation of higher-order chromatin structure and gene silencing over considerable distances in the genome.
Journal ArticleDOI
Nonallelic transvection of multiple imprinted loci is organized by the H19 imprinting control region during germline development.
Kuljeet Singh Sandhu,Chengxi Shi,Mikael Sjölinder,Zhihu Zhao,Anita Göndör,Liang Liu,Vijay K. Tiwari,Sylvain Guibert,Lina Emilsson,Marta P. Imreh,Rolf Ohlsson +10 more
TL;DR: A network of physically juxtaposed regions from the entire genome with the common denominator of being genomically imprinted is identified, concluding that one locus can directly or indirectly influence epigenetic states of multiple regions on other chromosomes with which it interacts.
Journal ArticleDOI
CTCF-binding sites within the H19 ICR differentially regulate local chromatin structures and cis-acting functions
Sylvain Guibert,Sylvain Guibert,Zhihu Zhao,Mikael Sjölinder,Mikael Sjölinder,Anita Göndör,Anita Göndör,Alejandro Fernandez,Vinod Pant,Rolf Ohlsson,Rolf Ohlsson +10 more
TL;DR: It is shown here that chromatin loop structures, impinging on CTCF-binding sites 1/2 and 3/4 at the 5′ and 3′-ends, within the maternal allele of the H19 imprinting control region (ICR), differ significantly.
Patent
Methods for analyzing interactions between at least two nucleic acid sequences
TL;DR: In this article, the authors propose a method for analyzing an interaction between at least two nucleic acid sequences by binding them together by at least one site and then digesting the bound nucleic acids to generate cohesive ends.