V
Vinod Pant
Researcher at University of Texas MD Anderson Cancer Center
Publications - 37
Citations - 3460
Vinod Pant is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Mdm2 & CTCF. The author has an hindex of 20, co-authored 33 publications receiving 3151 citations. Previous affiliations of Vinod Pant include International Centre for Genetic Engineering and Biotechnology & Uppsala University.
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Circular chromosome conformation capture (4C) uncovers extensive networks of epigenetically regulated intra-and interchromosomal interactions
Zhihu Zhao,Gholamreza Tavoosidana,Mikael Sjölinder,Anita Göndör,Piero Mariano,Sha Wang,Chandrasekhar Kanduri,Magda Lezcano,Kuljeet Singh Sandhu,Umashankar Singh,Vinod Pant,Vijay K. Tiwari,Sreenivasulu Kurukuti,Rolf Ohlsson +13 more
TL;DR: It is found that the direct interaction between differentially methylated regions was linked to epigenetic regulation of transcription in trans and the patterns of interactions specific to the maternal H19 imprinting control region underwent reprogramming during in vitro maturation of embryonic stem cells.
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Functional association of CTCF with the insulator upstream of the H19 gene is parent of origin-specific and methylation-sensitive
Chandrasekhar Kanduri,Vinod Pant,Dmitri Loukinov,Elena M. Pugacheva,Chen Feng Qi,Alan P. Wolffe,Rolf Ohlsson,Victor V. Lobanenkov +7 more
TL;DR: Observations suggest that molecular mechanisms of genomic imprinting may use an unusual ability of CTCF to interact with a diverse spectrum of variant target sites, some of which include CpGs that are responsible for methylation-sensitive C TCF binding in vitro and in vivo.
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Poly(ADP-ribosyl)ation regulates CTCF-dependent chromatin insulation
Wenqiang Yu,Vasudeva Ginjala,Vinod Pant,Igor Chernukhin,Joanne Whitehead,Dawn Farrar,Gholamreza Tavoosidana,Rituparna Mukhopadhyay,Chandrasekhar Kanduri,Mitsuo Oshimura,Andrew P. Feinberg,Victor V. Lobanenkov,Elena Klenova,Rolf Ohlsson +13 more
TL;DR: It is suggested that poly(ADP-ribosyl)ation imparts chromatin insulator properties to CTCF at both imprinted and nonimprinted loci, which has implications for the regulation of expression domains and their demise in pathological lesions.
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p53-Mediated Senescence Impairs the Apoptotic Response to Chemotherapy and Clinical Outcome in Breast Cancer
James G. Jackson,Vinod Pant,Qin Li,Qin Li,Leslie L. Chang,Alfonso Quintás-Cardama,Daniel Garza,Omid Tavana,Peirong Yang,Taghi Manshouri,Yi Li,Adel K. El-Naggar,Guillermina Lozano +12 more
TL;DR: It is shown that wild-type p53 activity hinders chemotherapy response and the need to reassess the paradigm for p53 in cancer therapy is demonstrated.
Journal ArticleDOI
The nucleotides responsible for the direct physical contact between the chromatin insulator protein CTCF and the H19 imprinting control region manifest parent of origin-specific long-distance insulation and methylation-free domains
Vinod Pant,Piero Mariano,Chandrasekhar Kanduri,Anita Mattsson,Victor V. Lobanenkov,Rainer Heuchel,Rolf Ohlsson +6 more
TL;DR: It is documented that point mutations of the nucleotides in physical contact with CTCF within the endogenous H19 ICR lead to loss of C TCF binding and Igf2 imprinting only when passaged through the female germline.