Sha Wang

TL;DR: It is found that the direct interaction between differentially methylated regions was linked to epigenetic regulation of transcription in trans and the patterns of interactions specific to the maternal H19 imprinting control region underwent reprogramming during in vitro maturation of embryonic stem cells.

TL;DR: Results indicate that delivery of siRNA mixtures by engineered EVs can effectively downregulate AR expression and induce LNCaP-AI cell apoptosis and the potential of TAT as efficient siRNA carriers by keeping the function of the cargoes.

TL;DR: A new idea for the diagnosis and treatment of gastrointestinal tumors is provided and the relationship between circRNAs and digestive tumor immunity is systematically discussed for the first time.

TL;DR: It is shown that CYP321A1, a xenobiotic-metabolizing P450 from Helicoverpa zea, a polyphagous insect of economic importance, has acquired and preserved a G4 DNA motif by selectively retaining a transposon known as HzIS1-3 that carries this G4DNA motif in its promoter region.

TL;DR: In this paper , a comprehensive survey of SE-associated lncRNAs in HCC is comprehensively outlined for the first time, which sheds lights on the merit of anchoring SE-driven oncogenic lncRNA for HCC treatment, and siHSAL3 loaded nanoparticles exert anti-tumor effect on HCC in vitro and in vivo.