P
Piero Mariano
Researcher at Uppsala University
Publications - 6
Citations - 1371
Piero Mariano is an academic researcher from Uppsala University. The author has contributed to research in topics: Insulator (genetics) & CTCF. The author has an hindex of 4, co-authored 6 publications receiving 1281 citations.
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Circular chromosome conformation capture (4C) uncovers extensive networks of epigenetically regulated intra-and interchromosomal interactions
Zhihu Zhao,Gholamreza Tavoosidana,Mikael Sjölinder,Anita Göndör,Piero Mariano,Sha Wang,Chandrasekhar Kanduri,Magda Lezcano,Kuljeet Singh Sandhu,Umashankar Singh,Vinod Pant,Vijay K. Tiwari,Sreenivasulu Kurukuti,Rolf Ohlsson +13 more
TL;DR: It is found that the direct interaction between differentially methylated regions was linked to epigenetic regulation of transcription in trans and the patterns of interactions specific to the maternal H19 imprinting control region underwent reprogramming during in vitro maturation of embryonic stem cells.
Journal ArticleDOI
The nucleotides responsible for the direct physical contact between the chromatin insulator protein CTCF and the H19 imprinting control region manifest parent of origin-specific long-distance insulation and methylation-free domains
Vinod Pant,Piero Mariano,Chandrasekhar Kanduri,Anita Mattsson,Victor V. Lobanenkov,Rainer Heuchel,Rolf Ohlsson +6 more
TL;DR: It is documented that point mutations of the nucleotides in physical contact with CTCF within the endogenous H19 ICR lead to loss of C TCF binding and Igf2 imprinting only when passaged through the female germline.
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Mutation of a Single CTCF Target Site within the H19 Imprinting Control Region Leads to Loss of Igf2 Imprinting and Complex Patterns of de Novo Methylation upon Maternal Inheritance
Vinod Pant,Sreenivasulu Kurukuti,Elena M. Pugacheva,Shaharum Shamsuddin,Piero Mariano,Rainer Renkawitz,Elena Klenova,Victor V. Lobanenkov,Rolf Ohlsson +8 more
TL;DR: It is proposed that site-specific interactions between various DNA-bound CTCF molecules may provide general focal points in the organization of looped chromatin domains involved in gene regulation.
Journal ArticleDOI
Multiple Nucleosome Positioning Sites Regulate the CTCF-Mediated Insulator Function of the H19 Imprinting Control Region†
Meena Kanduri,Chandrasekhar Kanduri,Piero Mariano,Alexander A. Vostrov,Wolfgang W. Quitschke,Victor V. Lobanenkov,Rolf Ohlsson +6 more
TL;DR: It is proposed that the NPSs ensure the fidelity of the repressed status of the maternal Igf2 allele during development by constitutively maintaining availability of the CTCF target sites.
The direct bypass of the chromatin insulator function of the H19 imprinting control region in human cancer cells : A novel mechanism of loss of IGF2 Imprinting
Claes Holmgren,Vinod Pant,Chandrasekhar Kanduri,Piero Mariano,Yupeng Lai,Meena Kanduri,Fredrick Öberg,N Papadogiannakis,Victor V. Lobanenkov,Susan Pfeifer,Rolf Ohlsson +10 more
TL;DR: The importance of CTCF in the formation of an epigenetically regulated chromatin insulator at the ICR, which in turn controls the expression pattern of H19 and Igf2 is confirmed and investigations into the loss of IGF2 imprinting in human cancer indicate the involvement of other novel mechanisms besides CTCf in the regulation of insulator function.