Z
Zong-Kang Zhang
Researcher at The Chinese University of Hong Kong
Publications - 29
Citations - 1917
Zong-Kang Zhang is an academic researcher from The Chinese University of Hong Kong. The author has contributed to research in topics: Medicine & Wnt signaling pathway. The author has an hindex of 15, co-authored 23 publications receiving 1098 citations.
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Journal ArticleDOI
Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation
Defang Li,Jin Liu,Baosheng Guo,Chao Liang,Lei Dang,Cheng Lu,Cheng Lu,Xiaojuan He,Xiaojuan He,Hilda Y. S. Cheung,Liang Xu,Changwei Lu,Bing He,Biao Liu,Atik Badshah Shaikh,Fangfei Li,Luyao Wang,Zhijun Yang,Doris W.T. Au,Songlin Peng,Zong-Kang Zhang,Bao-Ting Zhang,Xiaohua Pan,Xiaohua Pan,Airong Qian,Airong Qian,Peng Shang,Peng Shang,Lianbo Xiao,Lianbo Xiao,Baohong Jiang,Chris K C Wong,Jiake Xu,Zhaoxiang Bian,Zicai Liang,De-An Guo,Hailong Zhu,Weihong Tan,Aiping Lu,Ge Zhang +39 more
TL;DR: The results suggest that osteoclast-derived exosomal miR-214-3p transfers to osteoblasts to inhibit bone formation, which may be a strategy for treating skeletal disorders involving a reduction in bone formation.
Journal ArticleDOI
Recent Advances in SELEX Technology and Aptamer Applications in Biomedicine
Zhenjian Zhuo,Yuanyuan Yu,Maolin Wang,Jie Li,Zong-Kang Zhang,Jin Liu,Xiaohao Wu,Aiping Lu,Ge Zhang,Bao-Ting Zhang +9 more
TL;DR: The limitations and notable advances of aptamer selection are presented, and the different methods used in the kinetic characterization of aptamers are compared, to comprehensively review the current shortage and achievement ofaptamer-related technology.
Journal ArticleDOI
A water-soluble nucleolin aptamer-paclitaxel conjugate for tumor-specific targeting in ovarian cancer
Fangfei Li,Jun Lu,Jin Liu,Chao Liang,Maolin Wang,Luyao Wang,Defang Li,Houzong Yao,Qiulong Zhang,Jia Wen,Zong-Kang Zhang,Jie Li,Quanxia Lv,Xiaojuan He,Baosheng Guo,Daogang Guan,Yuanyuan Yu,Lei Dang,Xiaohao Wu,Yongshu Li,Guofen Chen,Feng Jiang,Shiguo Sun,Bao-Ting Zhang,Aiping Lu,Ge Zhang +25 more
TL;DR: A water-soluble nucleolin aptamer-paclitaxel conjugate that selectively accumulates in ovarian tumor issues displaying reduced toxicity and improved activity profiles is reported.
Journal ArticleDOI
Tumor cell-targeted delivery of CRISPR/Cas9 by aptamer-functionalized lipopolymer for therapeutic genome editing of VEGFA in osteosarcoma.
Chao Liang,Fangfei Li,Luyao Wang,Zong-Kang Zhang,Chao Wang,Bing He,Jie Li,Zhihao Chen,Atik Badshah Shaikh,Jin Liu,Xiaohao Wu,Songlin Peng,Lei Dang,Baosheng Guo,Xiaojuan He,Doris W.T. Au,Cheng Lu,Hailong Zhu,Bao-Ting Zhang,Aiping Lu,Ge Zhang +20 more
TL;DR: This work screened an OS cell-specific aptamer (LC09) and developed a LC09-functionalized PEG-PEI-Cholesterol (PPC) lipopolymer encapsulating CRISPR/Cas9 plasmids encoding VEGFA gRNA and Cas9, leading to effective VEG FA genome editing in tumor and reduced angiogenesis and bone lesion with no detectable toxicity.
Journal ArticleDOI
A newly identified lncRNA MAR1 acts as a miR‐487b sponge to promote skeletal muscle differentiation and regeneration
Zong-Kang Zhang,Jie Li,Daogang Guan,Chao Liang,Zhenjian Zhuo,Jin Liu,Aiping Lu,Ge Zhang,Bao-Ting Zhang +8 more
TL;DR: Skeletal muscle atrophy induced by either aging (sarcopenia) or mechanical unloading is associated with serious health consequences and long non‐coding RNAs (lncRNAs) are implicated as important regulators in numerous physiological and pathological processes.