L
Lei Dang
Researcher at Hong Kong Baptist University
Publications - 31
Citations - 1812
Lei Dang is an academic researcher from Hong Kong Baptist University. The author has contributed to research in topics: Osteoblast & Osteoclast. The author has an hindex of 16, co-authored 28 publications receiving 1244 citations.
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Journal ArticleDOI
Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation
Defang Li,Jin Liu,Baosheng Guo,Chao Liang,Lei Dang,Cheng Lu,Cheng Lu,Xiaojuan He,Xiaojuan He,Hilda Y. S. Cheung,Liang Xu,Changwei Lu,Bing He,Biao Liu,Atik Badshah Shaikh,Fangfei Li,Luyao Wang,Zhijun Yang,Doris W.T. Au,Songlin Peng,Zong-Kang Zhang,Bao-Ting Zhang,Xiaohua Pan,Xiaohua Pan,Airong Qian,Airong Qian,Peng Shang,Peng Shang,Lianbo Xiao,Lianbo Xiao,Baohong Jiang,Chris K C Wong,Jiake Xu,Zhaoxiang Bian,Zicai Liang,De-An Guo,Hailong Zhu,Weihong Tan,Aiping Lu,Ge Zhang +39 more
TL;DR: The results suggest that osteoclast-derived exosomal miR-214-3p transfers to osteoblasts to inhibit bone formation, which may be a strategy for treating skeletal disorders involving a reduction in bone formation.
Journal ArticleDOI
Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference-based bone anabolic strategy.
Chao Liang,Baosheng Guo,Heng Wu,Ningsheng Shao,Defang Li,Jin Liu,Lei Dang,Cheng Wang,Hui Li,Shaohua Li,Wing Ki Lau,Yu Cao,Zhijun Yang,Cheng Lu,Xiaojuan He,Doris W.T. Au,Xiaohua Pan,Bao-Ting Zhang,Changwei Lu,Hong Qi Zhang,Kinman Yue,Airong Qian,Peng Shang,Jiake Xu,Lianbo Xiao,Zhaoxiang Bian,Weihong Tan,Zicai Liang,Fuchu He,Lingqiang Zhang,Aiping Lu,Ge Zhang +31 more
TL;DR: The results indicate that osteoblast-specific aptamer-functionalized LNPs could act as a new RNAi-based bone anabolic strategy, advancing the targeted delivery selectivity of osteogenic siRNAs from the tissue level to the cellular level.
Journal ArticleDOI
A water-soluble nucleolin aptamer-paclitaxel conjugate for tumor-specific targeting in ovarian cancer
Fangfei Li,Jun Lu,Jin Liu,Chao Liang,Maolin Wang,Luyao Wang,Defang Li,Houzong Yao,Qiulong Zhang,Jia Wen,Zong-Kang Zhang,Jie Li,Quanxia Lv,Xiaojuan He,Baosheng Guo,Daogang Guan,Yuanyuan Yu,Lei Dang,Xiaohao Wu,Yongshu Li,Guofen Chen,Feng Jiang,Shiguo Sun,Bao-Ting Zhang,Aiping Lu,Ge Zhang +25 more
TL;DR: A water-soluble nucleolin aptamer-paclitaxel conjugate that selectively accumulates in ovarian tumor issues displaying reduced toxicity and improved activity profiles is reported.
Journal ArticleDOI
Tumor cell-targeted delivery of CRISPR/Cas9 by aptamer-functionalized lipopolymer for therapeutic genome editing of VEGFA in osteosarcoma.
Chao Liang,Fangfei Li,Luyao Wang,Zong-Kang Zhang,Chao Wang,Bing He,Jie Li,Zhihao Chen,Atik Badshah Shaikh,Jin Liu,Xiaohao Wu,Songlin Peng,Lei Dang,Baosheng Guo,Xiaojuan He,Doris W.T. Au,Cheng Lu,Hailong Zhu,Bao-Ting Zhang,Aiping Lu,Ge Zhang +20 more
TL;DR: This work screened an OS cell-specific aptamer (LC09) and developed a LC09-functionalized PEG-PEI-Cholesterol (PPC) lipopolymer encapsulating CRISPR/Cas9 plasmids encoding VEGFA gRNA and Cas9, leading to effective VEG FA genome editing in tumor and reduced angiogenesis and bone lesion with no detectable toxicity.
Journal ArticleDOI
Present Advances and Future Perspectives of Molecular Targeted Therapy for Osteosarcoma
Atik Badshah Shaikh,Fangfei Li,Min Li,Bing He,Xiaojuan He,Guofen Chen,Baosheng Guo,Defang Li,Feng Jiang,Lei Dang,Shaowei Zheng,Chao Liang,Jin Liu,Cheng Lu,Biao Liu,Jun Lu,Luyao Wang,Aiping Lu,Ge Zhang +18 more
TL;DR: This review summarizes the current development of molecular mechanisms and targets for osteosarcoma and Therapies that target these mechanisms with updated information on clinical trials are reviewed.