C
Changwei Lu
Researcher at Hong Kong Baptist University
Publications - 4
Citations - 722
Changwei Lu is an academic researcher from Hong Kong Baptist University. The author has contributed to research in topics: Osteoclast & Osteoblast. The author has an hindex of 4, co-authored 4 publications receiving 513 citations.
Papers
More filters
Journal ArticleDOI
Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation
Defang Li,Jin Liu,Baosheng Guo,Chao Liang,Lei Dang,Cheng Lu,Cheng Lu,Xiaojuan He,Xiaojuan He,Hilda Y. S. Cheung,Liang Xu,Changwei Lu,Bing He,Biao Liu,Atik Badshah Shaikh,Fangfei Li,Luyao Wang,Zhijun Yang,Doris W.T. Au,Songlin Peng,Zong-Kang Zhang,Bao-Ting Zhang,Xiaohua Pan,Xiaohua Pan,Airong Qian,Airong Qian,Peng Shang,Peng Shang,Lianbo Xiao,Lianbo Xiao,Baohong Jiang,Chris K C Wong,Jiake Xu,Zhaoxiang Bian,Zicai Liang,De-An Guo,Hailong Zhu,Weihong Tan,Aiping Lu,Ge Zhang +39 more
TL;DR: The results suggest that osteoclast-derived exosomal miR-214-3p transfers to osteoblasts to inhibit bone formation, which may be a strategy for treating skeletal disorders involving a reduction in bone formation.
Journal ArticleDOI
Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference-based bone anabolic strategy.
Chao Liang,Baosheng Guo,Heng Wu,Ningsheng Shao,Defang Li,Jin Liu,Lei Dang,Cheng Wang,Hui Li,Shaohua Li,Wing Ki Lau,Yu Cao,Zhijun Yang,Cheng Lu,Xiaojuan He,Doris W.T. Au,Xiaohua Pan,Bao-Ting Zhang,Changwei Lu,Hong Qi Zhang,Kinman Yue,Airong Qian,Peng Shang,Jiake Xu,Lianbo Xiao,Zhaoxiang Bian,Weihong Tan,Zicai Liang,Fuchu He,Lingqiang Zhang,Aiping Lu,Ge Zhang +31 more
TL;DR: The results indicate that osteoblast-specific aptamer-functionalized LNPs could act as a new RNAi-based bone anabolic strategy, advancing the targeted delivery selectivity of osteogenic siRNAs from the tissue level to the cellular level.
Journal ArticleDOI
Osteoclastic miR-214 targets TRAF3 to contribute to osteolytic bone metastasis of breast cancer
Jin Liu,Defang Li,Lei Dang,Chao Liang,Baosheng Guo,Cheng Lu,Cheng Lu,Xiaojuan He,Xiaojuan He,Hilda Y. S. Cheung,Bing He,Biao Liu,Fangfei Li,Jun Lu,Luyao Wang,Atik Badshah Shaikh,Feng Jiang,Changwei Lu,Songlin Peng,Zong-Kang Zhang,Bao-Ting Zhang,Xiaohua Pan,Xiaohua Pan,Lianbo Xiao,Lianbo Xiao,Aiping Lu,Ge Zhang +26 more
TL;DR: Inhibition of osteoclastic miR-214-3p may be a potential therapeutic strategy for breast cancer patients with OBM and the intraosseous TRAF3 could be a promising biomarker for evaluation of the treatment response of antagomir-214 -3p.
Journal ArticleDOI
Increased PLEKHO1 within osteoblasts suppresses Smad-dependent BMP signaling to inhibit bone formation during aging
Jin Liu,Chao Liang,Baosheng Guo,Xiaohao Wu,Defang Li,Zong-Kang Zhang,Kang Zheng,Kang Zheng,Lei Dang,Xiaojuan He,Changwei Lu,Songlin Peng,Xiaohua Pan,Xiaohua Pan,Bao-Ting Zhang,Aiping Lu,Ge Zhang +16 more
TL;DR: The increased PLEkho1 could suppress Smad‐dependent BMP signaling to inhibit bone formation during aging, indicating the translational potential of targeting PLEKHO1 in osteoblast as a novel bone anabolic strategy for reversing established osteoporosis during aging.