Zongyang Lu

TL;DR: In vivo generation of mouse models carrying clinically relevant mutations using C→T and A→G editors is demonstrated, making it feasible to model and potentially cure relevant genetic diseases.

TL;DR: It is shown that, through its binding protein YTHDF1, m6A promotes protein translation of target transcripts in response to neuronal stimuli in the adult mouse hippocampus, thereby facilitating learning and memory.

TL;DR: A CRISPR–Cpf1-based BE is developed by fusing the rat cytosine deaminase APOBEC1 to a catalytically inactive version of Lachnospiraceae bacterium Cpf 1, which recognizes a T-rich PAM sequence and catalyzes C-to-T conversion in human cells, while inducing low levels of indels, non-C- to-T substitutions and off-target editing.

TL;DR: It is shown that the original version of catalytically dead Cas12a (dCas12a)-conjugated BEs induce a basal level of DNA breaks and minimally activate DDR proteins, including H2AX, ATM, ATR, and p53, in mammalian cells.

TL;DR: The developed hybrid manufacturing method can be adapted to the fabrication of other complex micro- and nanodevices for photonics or other research areas and is shown that the transmission of the compound eye can be improved by 2.3% for the wavelength of 632.8 nm and a clearer image can be formed by the fabricated compound eye with antireflective nanostructures.