Yajing Liu

TL;DR: In vivo generation of mouse models carrying clinically relevant mutations using C→T and A→G editors is demonstrated, making it feasible to model and potentially cure relevant genetic diseases.

TL;DR: It is shown that, through its binding protein YTHDF1, m6A promotes protein translation of target transcripts in response to neuronal stimuli in the adult mouse hippocampus, thereby facilitating learning and memory.

TL;DR: A CRISPR–Cpf1-based BE is developed by fusing the rat cytosine deaminase APOBEC1 to a catalytically inactive version of Lachnospiraceae bacterium Cpf 1, which recognizes a T-rich PAM sequence and catalyzes C-to-T conversion in human cells, while inducing low levels of indels, non-C- to-T substitutions and off-target editing.

TL;DR: In this paper, the deaminases that are integral to commonly used DNA base editors often bind to RNA, and the authors quantitatively evaluated RNA single nucleotide variations (SNVs) that were induced by CBEs or ABEs.

TL;DR: It is reported that sciatic nerve lesion elevates levels of m6A-tagged transcripts encoding many regeneration-associated genes and protein translation machinery components in the adult mouse dorsal root ganglion (DRG).