Bishop Heber College

About: Bishop Heber College is a based out in . It is known for research contribution in the topics: Thin film & Band gap. The organization has 548 authors who have published 692 publications receiving 7144 citations.

A global comparison and analysis of neuraminidase h1n1 strain of influenza a

Abstract: Objective: To evaluate the variation of neuraminidase (NA) protein from various H1N1 strain for drug designing Methods: In this study we have used 12 sequences of NA protein from various countries, retrieved from UniprotKB database We have performed structural analysis, antigenic and glycosylation site prediction between NA proteins of influenza A strains Results: Antigenic variants in sequence of NA H1N1 strain from Italy were found to be unique and were not present in any other NA H1N1 Strains from Italy and Thailand were found to be distantly related while others are closely related We observed the maximum similarity from position 84 to 448 using disorder prediction analysis of different strains Sequences from 1 to 83 and 449 to 469 showed the maximum dissimilarity among the NA Proteins Conclusion: This study focuses on the regions of sequence similarity and dissimilarity of NA in H1N1 strains from different countries The results in this paper are based on currently available sequences for NA of H1N1 strains and bioinformatic tools Our study will help in understanding of the regions of high variability due to mutations and conserved domains that can be potential targets for drug development

Polymer Macromolecules to Polymeric Nanostructures: Efficient Antibacterial Candidates

Abstract: Microbes pose a serious threat to life among human beings due to numerous infectious diseases. Though there is significant progress in the development of effective antimicrobial drugs, many infectious diseases are still difficult to treat. Polymers render a potential antimicrobial strategy to combat pathogens and gained a considerable attention in the recent past. Polyamine compounds are familiar about their vitality in many biological processes. Conspicuously, polyethyleneimine (PEI) as a polymeric chelating agent draws advantages such as high water solubility, modulation of functional groups, reliable molecular weight and physico-chemical stabilities. As reactive amino groups are abundant, a wide range of chemically modified cations with desirable properties make PEI remarkable. PEI offers an effective antimicrobial property, thanks to the hydrophobicity and positive charge density potentiated by alkylation. N-alkyl-substituted PEI immobilized over various knitted textiles showed evidence of strong bactericidal activity against a variety of airborne bacteria. It has also been realized that the molecular weight of polyethyleneimine and the antimicrobial activity are directly proportional to each other. The structure-activity relationship (SAR) plays a compelling role in comprehending the enhanced antimicrobial activity of linear and branched PEIs. In accordance with the above details, the present chapter focuses on the synthesis, characterization and antimicrobial applications of certain polymers, polymer metal complexes and nanopolymer materials.

Use Pattern of Social Networking Sites (SNS) Among the Women Students of St.Joseph’s College, Tiruchirappalli

Abstract: Social Networking Sites(SNS) such as Facebook, Whatsapp etc. attracted millions of users, many of whom have integrated these sites into their daily practices. In this paper an attempt is made to find the use pattern of Social Networking Sites among the women students of St. Joseph’s College, Tiruchirappalli. Data has been collected from 143 respondents using questionnaire method. The key findings are i)70.6% of the respondents are using Whatsapp ii) 38.5% of the respondents are using SNS for entertainment iii) 30% of the respondents spent 1-2 hours daily for SNS iv) 46.8% of the respondents upload videos and pictures in SNS v) 85.3% of the respondents felt SNS are useful to them. It is followed by suggestions.

Anthracen-9-ylmethylene-(4-methoxyphenyl)amine: efficient promoter for silver-free palladium-catalyzed aerobic oxidative Sonogashira reactions

Abstract: An efficient protocol for the synthesis of unsymmetrical substituted diarylacetylenes by the C(sp2)–C(sp) cross-coupling reactions of substituted phenylacetylenes and electronically different arylboronic acids has been developed. Anthracen-9-ylmethylene-(4-methoxyphenyl)amine was employed as an efficient promoter in this Pd(OAc)2-catalyzed oxidative Sonogashira reaction in air in the absence of silver salt under optimized reaction conditions. The impact of reaction parameters such as solvent, base, reaction temperature and time in this silver-free aerobic oxidative Sonogashira cross-coupling reaction was also evaluated. Electron-deficient phenylacetylenes, which are sluggish coupling partners in the traditional Sonogashira reaction, underwent coupling in this protocol. The catalytic system is inexpensive, effortlessly attainable and highly flexible for functionalized phenylacetylenes and arylboronic acids.