Institution
Center for Global Development
Nonprofit•Washington D.C., District of Columbia, United States•
About: Center for Global Development is a nonprofit organization based out in Washington D.C., District of Columbia, United States. It is known for research contribution in the topics: Poverty & Population. The organization has 1472 authors who have published 3891 publications receiving 162325 citations.
Topics: Poverty, Population, Politics, Developing country, Government
Papers published on a yearly basis
Papers
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TL;DR: Treatment with tapentadol ER 100–250 mg twice daily or oxycodone HCl CR 20–50mg twice daily was effective for the management of moderate to severe chronic osteoarthritis-related knee pain, with substantially lower incidences of gastrointestinal-related TEAEs associated with treatment withTapentadl ER than with oxy codone CR.
Abstract: Background: Tapentadol is a novel, centrally acting analgesic with μ-opioid receptor agonist and norepinephrine reuptake inhibitor activity. Objective: To evaluate the efficacy and safety of tapentadol extended release (ER) compared with oxycodone controlled release (CR) for management of moderate to severe chronic osteoarthritis-related knee pain. Methods: This was a randomized, double-blind, active- and placebo-controlled, parallel-arm, multicentre, phase III study during which patients received tapentadol ER, oxycodone CR or placebo for a 3-week titration period followed by a 12-week maintenance period. The study was carried out at sites in Australia, Canada, New Zealand and the US. A total of 1030 patients with chronic osteoarthritis-related knee pain were randomized to receive tapentadol ER 100–250 mg twice daily, oxycodone HCl CR 20–50 mg twice daily or placebo. Primary endpoints (as determined prior to initiation of the study) were the changes from baseline in average daily pain intensity (rated by patients on an 11-point numerical rating scale) over the last week of maintenance and over the entire 12-week maintenance period; last observation carried forward was used to impute missing values after early treatment discontinuation. Results: Efficacy and safety were evaluated for 1023 patients. Tapentadol ER significantly reduced average pain intensity from baseline to week 12 of the maintenance period versus placebo (least squares mean [LSM] difference [95% CI], −0.7 [−1.04, −0.33]), and throughout the maintenance period (−0.7 [−1.00, −0.33]). Oxycodone CR significantly reduced average pain intensity from baseline throughout the maintenance period versus placebo (LSM difference [95% CI], −0.3 [−0.67, −0.00]) but not at week 12 (−0.3 [−0.68, 0.02]). A significantly higher percentage of patients achieved ≥50% improvement in pain intensity in the tapentadol ER group (32.0% [110/344]) compared with the placebo group (24.3% [82/337]; p = 0.027), indicating a clinically significant improvement in pain intensity, while a significantly lower percentage of patients achieved ≥50% improvement in pain intensity in the oxycodone CR group (17.3% [59/342]; p = 0.023 vs placebo). In the placebo, tapentadol ER and oxycodone CR groups, respectively, 61.1% (206/337), 75.9% (261/344) and 87.4% (299/342) of patients reported at least one treatment-emergent adverse event (TEAE); incidences of gastrointestinal-related TEAEs were 26.1% (88/337), 43.0% (148/344) and 67.3% (230/342). Conclusion: Treatment with tapentadol ER 100–250 mg twice daily or oxycodone HCl CR 20–50 mg twice daily was effective for the management of moderate to severe chronic osteoarthritis-related knee pain, with substantially lower incidences of gastrointestinal-related TEAEs associated with treatment with tapentadol ER than with oxycodone CR. [Trial registration number: NCT00421928 (ClinicalTrials.gov Identifier)]
230 citations
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TL;DR: It is shown that mirabegron 50 mg was as efficacious as antimuscarinics in reducing the frequency of micturition incontinence and UUI episodes and lower incidence of dry mouth, the most common adverse event reported with antimus carinics and one of the main causes of discontinuation of treatment.
227 citations
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01 Jan 2008TL;DR: In this paper, Bebbington, Hickey and Mitlin discuss the challenge of development alternatives and how NGOs can make a difference in the field of sustainable development, and the challenges they face.
Abstract: Introduction: can NGOs make a difference? The challenge of development alternatives / Anthony J. Bebbington, Samuel Hickey and Diana C. Mitlin
226 citations
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TL;DR: A strengthened effort across multiple sectors with effective economic tools, such as price policies and insurance, is necessary to reduce the non-communicable disease burden and to create sustainable and healthy cities.
226 citations
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TL;DR: In this article, the authors focus on the negative effects of micro-finance activities on the prospects of poor people and highlight the need to monitor not only their positive impacts but also their negative effects, and not rest on their laurels.
Abstract: This note focuses on the ‘downside’ of microfinance: on the way in which some microfinance activities can damage the prospects of poor people. It is not a polemic that argues that microfinance has failed—there is much evidence, not least from my work with colleagues, that it can help many poor people improve their lives. Rather, it is a reminder that those who provide microfinancial services (referred to here as MFIs, or microfinance institutions, but recognizing that many institutions also provide enterprise development or social development services) need to monitor carefully not only their positive impacts but also their negative effects, look to the future, and not rest on their laurels. The ‘microfinance industry’ needs to practice more humility about what it has achieved (outside of Bangladesh it has not even scratched the surface of poverty, for example in Kenya less than 70 000 people out of an estimated 9 to 10 million poor people have access to microfinance) and deepen its understanding of the financial service needs of poor people (see Rutherford in this issue).
226 citations
Authors
Showing all 1486 results
Name | H-index | Papers | Citations |
---|---|---|---|
William Easterly | 93 | 253 | 49657 |
Michael Kremer | 78 | 294 | 29375 |
George G. Nomikos | 70 | 202 | 13581 |
Tommy B. Andersson | 70 | 216 | 15167 |
Mark Rounsevell | 69 | 253 | 20296 |
David Hulme | 69 | 324 | 18616 |
Lant Pritchett | 68 | 260 | 35341 |
Jane E. Freedman | 65 | 348 | 13704 |
Arvind Subramanian | 64 | 220 | 20452 |
Dale Whittington | 63 | 265 | 10949 |
Michael Walker | 61 | 319 | 14864 |
Sanjeev Gupta | 59 | 575 | 14306 |
Joseph C. Cappelleri | 59 | 484 | 20193 |
Nathaniel P. Katz | 58 | 211 | 18483 |
Anthony Bebbington | 57 | 247 | 13362 |