Institution
Chiron Corporation
About: Chiron Corporation is a based out in . It is known for research contribution in the topics: Antigen & Hepatitis C virus. The organization has 1973 authors who have published 1969 publications receiving 172330 citations.
Topics: Antigen, Hepatitis C virus, Virus, Antibody, Peptide sequence
Papers published on a yearly basis
Papers
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29 Jan 2004TL;DR: In this article, the authors proposed compositions comprising one or more influenza antigens, detoxified ADP-ribosylating proteins, and chitosans to generate an immune response to influenza.
Abstract: The invention relates to compositions comprising one or more influenza antigens, one or more detoxified ADP-ribosylating proteins, and one or more chitosans The invention also relates to methods of using these compositions to generate an immune response to influenza
29 citations
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TL;DR: Solution NMR studies indicate that although CHIR-2279 and CHir-4531 have identical backbones and termini, and very similar side chains, they do not display the same solution conformational characteristics.
Abstract: Synthesis and screening of combinatorial librariesfor pharmaceutical lead discovery is a rapidlyexpanding field. Oligo-N-substituted glycines (NSGs)were one of the earliest sources of moleculardiversity in combinatorial libraries. In one of thefirst demonstrations of the power of combinatorialchemistry, two NSG trimers, CHIR-2279 and CHIR-4531,were identified as nM ligands for two 7-transmembraneG-protein-coupled receptors. The NMR characterizationof these two lead compounds was undertaken to verifycovalent connectivity and to determine solutionconformations, if any. The sequential chemical shiftassignments were performed using a new strategy forassigning 1H and 13C resonances of NSGs. The conformational preferences were then determined inboth an aqueous co-solvent system and an organicsolvent to probe the effects of hydrophobic collapse. NSGs are expected to be more flexible than peptidesdue to the tertiary amide, with both cis andtrans amide bond conformations being accessible. Solution NMR studies indicate that although CHIR-2279and CHIR-4531 have identical backbones and termini,and very similar side chains, they do not display thesame solution conformational characteristics.
29 citations
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TL;DR: Vaccination strategies that substantially reduced or eliminated symptomatic disease following challenge infection appeared to block the establishment of a latent infection of herpes simplex virus.
29 citations
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TL;DR: In this paper, a simple and versatile method for the synthesis of Peptide Nucleic Acids (PNA) from readily available building blocks has been developed based on submonomer solid phase synthesis and allows for the structural variation of both the backbone and the nucleobase sidechain.
29 citations
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TL;DR: V2-loop deleted trimeric envelope (Env) immunogens from subtypes B and C human immunodeficiency virus type 1 (HIV-1) strains were produced for ongoing and future clinical evaluations with other HIV antigens, adjuvants and deliveries.
29 citations
Authors
Showing all 1973 results
Name | H-index | Papers | Citations |
---|---|---|---|
Marc W. Kirschner | 162 | 457 | 102145 |
Paul Tempst | 148 | 309 | 89225 |
J. Fraser Stoddart | 147 | 1239 | 96083 |
Rino Rappuoli | 132 | 816 | 64660 |
Carl-Henrik Heldin | 131 | 520 | 67528 |
David J. Kwiatkowski | 129 | 502 | 64377 |
Graeme I. Bell | 127 | 531 | 61011 |
Anthony Cerami | 123 | 477 | 79895 |
David B. Dunger | 110 | 703 | 55784 |
Michael Simons | 106 | 401 | 38071 |
Jay A. Levy | 104 | 451 | 37920 |
Christer Betsholtz | 104 | 357 | 56771 |
Ken A. Dill | 99 | 401 | 41289 |
Michael P. Busch | 96 | 758 | 43075 |
Sung-Hou Kim | 93 | 371 | 34091 |