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Institution

Duquesne University

EducationPittsburgh, Pennsylvania, United States
About: Duquesne University is a education organization based out in Pittsburgh, Pennsylvania, United States. It is known for research contribution in the topics: Population & Health care. The organization has 3615 authors who have published 7169 publications receiving 180066 citations. The organization is also known as: Duquesne University of the Holy Spirit.


Papers
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Journal ArticleDOI
TL;DR: 6MWT performance in persons with multiple sclerosis was explained by balance confidence (ABC) and stair-climbing ability (FST) and may be practical clinical measures for explaining walking ability and determining risk for disablement in people with MS.
Abstract: Purpose: The primary purpose of this study was to determine the extent to which health factors, functional measures, and pulmonary impairment explain performance on 6-Minute Walk Test (6MWT) distance in ambulatory persons with multiple sclerosis (MS). Another purpose was to determine the effect of disability and age on 6MWT performance and explanatory factors. Methods: A cross-sectional study design was used to evaluate factors that explain performance on the 6MWT in 64 community-dwelling persons with MS-related disability (Expanded Disability Status Scale [EDSS] 3.8±1.6). Of the 64 participants, 43 (67.2%) exhibited mild disability (EDSS <4.0) and 21 (32.8%) had moderate disability (EDSS 4.0–6.5). A regression analysis compared 6MWT performance to measures of health factors (EDSS, number of medications, number of comorbidities, resting HR, systolic and diastolic blood pressure [BP]); physical performance (functional stair test [FST], sit-to-stand test [SST], static standing balance [BAL], Fatigue Severity Scale [FSS], Activities-specific Balance Confidence [ABC] Scale); and pulmonary function (forced expiratory volume in 1 second [FEV1], forced vital capacity [FVC], maximal voluntary ventilation [MVV], maximal inspiratory pressure [MIP], maximal expiratory pressure [MEP]). Results: EDSS, ABC, FST, SST, BAL, MVV, MIP, and MEP were significantly associated with 6MWT distance after adjusting for age. Multiple step-wise linear regression analysis revealed that ABC, FST, and BAL were significant and independent explanatory factors of 6MWT distance. ABC and FST explained 75% of the variance in 6MWT performance (R2=0.75). Curvilinear regression analysis revealed that the FST is the most significant explanatory factor for 6MWT distance, explaining 79% of the variance (R2=0.79). Conclusions: 6MWT performance in persons with MS was explained by balance confidence (ABC) and stair-climbing ability (FST). The ABC and FST may be practical clinical measures for explaining walking ability and determining risk for disablement in persons with MS.

67 citations

Journal ArticleDOI
TL;DR: A novel RNA-dependent repair mechanism of DSBs in post-mitotic neurons is shown and it is demonstrated that defects in this pathway may contribute to neuronal genomic instability and consequent neurodegenerative phenotypes such as those seen in Alzheimer's disease.

67 citations

Journal ArticleDOI
TL;DR: The findings provide evidence of compensatory increases in SHR due to pain associated with full-thickness rotator cuff tear, and the contribution of glenohumeral elevation increased significantly whereas scapular upward and downward rotation tended to decrease.

67 citations

Journal ArticleDOI
TL;DR: In this article, a course on classroom assessment is compared to an introductory psychometrics course, and the authors discuss the role of instruction concerning grading and communicating in such a course.
Abstract: How should a course on classroom assessment differ from an introductory psychometrics course? How should such a course be taught? How large a role should instruction concerning grading and communicating play in such a course?

67 citations


Authors

Showing all 3668 results

NameH-indexPapersCitations
Krzysztof Matyjaszewski1691431128585
William L. Jorgensen10858695112
John C. Avise10541353088
Rongchao Jin10133242920
Paul Knochel99237344786
Gwendolen Jull8741026556
Hugh M. Robertson8319727173
Peter Wipf8376725316
Ivet Bahar7839124228
Luk N. Van Wassenhove7832229163
Carl H. Snyderman7648122390
Ronald S. Oremland7619819671
Jeffrey L. Brodsky7125618315
Maarten J. Postma6275333409
Alan J. Russell6228013894
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202315
202272
2021412
2020347
2019336
2018378