Institution
Duquesne University
Education•Pittsburgh, Pennsylvania, United States•
About: Duquesne University is a education organization based out in Pittsburgh, Pennsylvania, United States. It is known for research contribution in the topics: Population & Health care. The organization has 3615 authors who have published 7169 publications receiving 180066 citations. The organization is also known as: Duquesne University of the Holy Spirit.
Papers published on a yearly basis
Papers
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TL;DR: The reported nanoemulsion's properties, including small particle size, visibility under (19)F NMR and NIR fluorescence spectroscopy, and the ability to carry drugs make it an attractive potential theranostic agent for cancer imaging and treatment.
48 citations
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TL;DR: A novel neuroprotective role for secreted NAMPT is suggested in the protection of white matter after ischemic injury, and the mechanism of protection appeared to be through extracellular release of NAM PT.
Abstract: Nicotinamide phosphoribosyltransferase (NAMPT) has been implicated in neuroprotection against ischemic brain injury, but the mechanism underlying its protective effect remains largely unknown. To further examine the protective effect of NAMPT against ischemic stroke and its potential mechanism of action, we generated a novel neuron-specific NAMPT transgenic mouse line. Transgenic mice and wild-type littermates were subjected to transient occlusion of the middle cerebral artery (MCAO) for 60 minutes. Neuron-specific NAMPT overexpression significantly reduced infarct volume by 65% (P=0.018) and improved long-term neurologic outcomes (P≤0.05) compared with littermates. Interestingly, neuronal overexpression of NAMPT increased the area of myelinated fibers in the striatum and corpus callosum, indicating that NAMPT protects against white matter injury. The mechanism of protection appeared to be through extracellular release of NAMPT. First, NAMPT was secreted into the extracellular medium by primary cortical neurons exposed to ischemia-like oxygen–glucose deprivation (OGD) in vitro. Second, conditioned medium from NAMPT-overexpressing neurons exposed to OGD protected cultured oligodendrocytes from OGD. Third, the protective effects of conditioned medium were abolished by antibody-mediated NAMPT depletion, strongly suggesting that the protective effect is mediated by the extracellular NAMPT released into in the medium. These data suggest a novel neuroprotective role for secreted NAMPT in the protection of white matter after ischemic injury.
48 citations
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TL;DR: The authors explored different uses of the term reflexivity in qualitative research and argued that integration of these perspectives is possible thanks to their common foundation in phenomenology and henneneutics, and an example of such integration in practice is provided.
Abstract: This paper will explore different uses of the term reflexivity in qualitative research. After discussing the foundational role of phenomenology and hermeneutics in the practices of reflexivity, this paper will present four methodological approaches to reflexivity. Distinctions will be made between personal reflexivity, interpersonal reflexivity, methodological reflexivity, and contextual reflexivity, and examples of research from each perspective will be presented. It will be argued that integration of these perspectives is possible thanks to their common foundation in phenomenology and henneneutics, and an example of such integration in practice will be provided.
48 citations
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TL;DR: The stalagmite MC01 was recovered from Macal Chasm cave on the Vaca Plateau of Belize in 1995, and an initial paleoclimate interpretation was published in 2007.
48 citations
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TL;DR: The knowledge of Tg for various formulations becomes especially important during the initial stages of formulation development, when formulation screening is done predominantly by monitoring the stability of various formulations under accelerated conditions and extrapolating their stability to the storage temperature.
48 citations
Authors
Showing all 3668 results
Name | H-index | Papers | Citations |
---|---|---|---|
Krzysztof Matyjaszewski | 169 | 1431 | 128585 |
William L. Jorgensen | 108 | 586 | 95112 |
John C. Avise | 105 | 413 | 53088 |
Rongchao Jin | 101 | 332 | 42920 |
Paul Knochel | 99 | 2373 | 44786 |
Gwendolen Jull | 87 | 410 | 26556 |
Hugh M. Robertson | 83 | 197 | 27173 |
Peter Wipf | 83 | 767 | 25316 |
Ivet Bahar | 78 | 391 | 24228 |
Luk N. Van Wassenhove | 78 | 322 | 29163 |
Carl H. Snyderman | 76 | 481 | 22390 |
Ronald S. Oremland | 76 | 198 | 19671 |
Jeffrey L. Brodsky | 71 | 256 | 18315 |
Maarten J. Postma | 62 | 753 | 33409 |
Alan J. Russell | 62 | 280 | 13894 |