Duquesne University

About: Duquesne University is a education organization based out in Pittsburgh, Pennsylvania, United States. It is known for research contribution in the topics: Population & Health care. The organization has 3615 authors who have published 7169 publications receiving 180066 citations. The organization is also known as: Duquesne University of the Holy Spirit.

Use of Chitosan in Compressed Tablets of Diclofenac Sodium: Inhibition of Drug Release in an Acidic Environment

Abstract: The purpose of this study was to evaluate the potential utility of chitosan (I) in inhibiting diclofenac sodium (II) release in the gastric environment from a directly compressible tablet formulation. I, subjected to depolymerization to improve its microcrystallinity and subsequent compressibility, was then used to prepare tablets of II. A full-factorial design was employed to evaluate the effects of degree of N-deacetylation of I, and the pH and ionic strengths, mu, of the dissolution media on drug release. Directly compressible tablets were prepared from admixtures of 25 mg of II, 174 mg of I of various degrees of N-deacetylation (74, 87, and 92%), and 1 mg of magnesium stearate. The in vitro dissolution studies were performed using aqueous buffers (pHs 1.2, 3.8, and 6.8, and mu of approximately 1.0 and 0.1). The slopes of logarithmically transformed cumulative percent released-time curves (from t = 0 to t = 5 hr) were compared. Analyses of variance performed using SAS indicated that the degree of N-deacetylation of chitosan significantly affected drug release at pHs 1.2 and 6.8 (p 0.198). Besides the poor aqueous solubility of II, the two factors possibly affecting the drug release in the acidic environment were (a) the formation of a rate-limiting chitosan gel barrier; and (b) the ionic interaction of II with ionized amino groups of I.

“Am i still one of them?”: Bicultural immigrant managers navigating social identity threats when spanning global boundaries

Abstract: We examine the practice of nominating bicultural immigrants to manage knowledge-intensive projects sourced from their host to their home countries. We focus on their actions vis-a-vis global collaborators and unpack psychological processes involved. Managers in these positions have to navigate the workplace social identity threat that arises from being associated with the home country group – a lower status group in this context. How they navigate this threat shapes the way they use their bicultural competencies and authority as managers. When they embrace their home country identity, immigrant managers tend to enable knowledge-based boundary spanning through actions empowering home country collaborators, such as teaching missing competencies, connecting to important stakeholders, and soliciting input. Instead, when distancing from their home country identity, they tend to hinder collaborators by micromanaging, narrowing communication channels, and suppressing input. We develop theoretical implications for the study of global boundary spanning, bicultural managers, and workplace social identity. This article is protected by copyright. All rights reserved.

Status, Biology, and Conservation Priorities for North America's Eastern Golden Eagle (Aquila chrysaetos) Population

Abstract: TODD KATZNER,1,2,26 BRIAN W. SMITH,3 TRICIA A. MILLER,4,5 DAVID BRANDES,6 JEFF COOPER,7 MICHAEL LANZONE,5,8 DANIEL BRAUNING,9 CHRISTOPHER FARMER,10 SERGIO HARDING,11 DAVID E. KRAMAR,12 CRAIG KOPPIE,13 CHARLES MAISONNEUVE,14 MARK MARTELL,15 ELIZABETH K. MOJICA,16 CHARLIE TODD,17 JUNIOR A. TREMBLAY,18 MARIA WHEELER,19 DAVID F. BRINKER,20 TONY E. CHUBBS,21 ROLF GUBLER,22 KIERAN O’MALLEY,23 SCOTT MEHUS,24 BRADY PORTER,19 ROBERT P. BROOKS,4 BRYAN D. WATTS,16 AND KEITH L. BILDSTEIN25

Enhancing and Extending Biological Performance and Resilience.

Abstract: Human performance, endurance, and resilience have biological limits that are genetically and epigenetically predetermined but perhaps not yet optimized. There are few systematic, rigorous studies o...

Responsiveness and minimal detectable change of the dynamic gait index and functional gait index in persons with balance and vestibular disorders.

Abstract: Background and Purpose:We performed a retrospective chart review to determine the responsiveness and minimal detectable change (MDC95) in persons with balance and vestibular disorders with the dynamic gait index (DGI) and the functional gait assessment (FGA).Methods:The study cohort consisted of 326