Institution
Exponent
Company•Menlo Park, California, United States•
About: Exponent is a company organization based out in Menlo Park, California, United States. It is known for research contribution in the topics: Population & Risk assessment. The organization has 1589 authors who have published 2680 publications receiving 88140 citations.
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TL;DR: The goals of the work reported here were to develop physiologically based pharmacokinetic (PBPK) models of EGEEA and EGEE for pregnant rats and humans that were considered valid based on the ability of the model to accurately predict 2-EAA concentrations in rat blood, urine, and fetal tissue.
43 citations
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TL;DR: Posterior thoracolumbar spine implants retrieved as part of routine clinical practice over a 2-year period were analyzed to identify wear and corrosion and wore and corrosion mainly located at the interfaces with hooks, screws, or cross-connectors.
Abstract: STUDY DESIGN Posterior thoracolumbar spine implants retrieved as part of routine clinical practice over a 2-year period were analyzed to identify wear and corrosion. OBJECTIVE Engineering analyses of retrieved posterior instrumentation for indications of performance and failure and correlation of this information with clinical factors. SUMMARY OF BACKGROUND DATA Recent studies have reported spinal instrumentation particulate wear debris and have noted the importance of design considerations at implant connector interfaces. METHODS A total of 57 implants were analyzed from patients (39 female, 18 male) whose average age at implantation was 43.9 years (range, 13.7-77.4 years). Time of implantation ranged from 2 months to 13.5 years. The top 3 implantation diagnoses were radiculopathy (33%), scoliosis (30%), and back pain (25%). Metallurgical analyses were performed to characterize the wear and/or corrosion, and fractures of the implants. RESULTS Wear was present in 75%, corrosion in 39%, and fractures in 7% of the retrieved implants. Wear and/or corrosion was more prevalent, with respect to the total number of implants retrieved, in implants that had been in service at least 1 year. There was no evidence of corrosion in any of the Ti implants, whereas corrosion was present (with wear) in 58% of the stainless steel (SS) implants. Wear and corrosion were more frequently observed in long rods than in short rods. Implantation times were longer for SS implants than for Ti implants. CONCLUSIONS Retrieved rods exhibited corrosion, wear, and fracture, with wear and corrosion mainly located at the interfaces with hooks, screws, or cross-connectors. The mechanisms causing this material loss in situ, as well as what local or systemic responses it may stimulate are of clinical significance and should be studied further.
43 citations
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TL;DR: A new hybrid material consisting of ferrocene and layered carbon was prepared through a facile intercalation approach and exhibited excellent electrochemical properties in electrocatalytic oxidation of ascorbic acid (AA).
Abstract: A new hybrid material consisting of ferrocene and layered carbon (LC: graphene oxide (GO) or reduced graphene oxide (RGO)) was prepared through a facile intercalation approach. The structure of ferrocene was well maintained while the strong π–π interaction between LC and ferrocene remarkably suppressed the sublimation of ferrocene and promoted ferrocene to decompose into iron nanoparticles in between layers of LC. The hybrid exhibited excellent electrochemical properties in electrocatalytic oxidation of ascorbic acid (AA).
43 citations
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University of Chicago1, University of Cagliari2, Mario Negri Institute for Pharmacological Research3, University of Milan4, Stanford University5, Exponent6, University of New South Wales7, Roger Williams Medical Center8, Boston University9, University of British Columbia10, National Institutes of Health11, University of York12, Harvard University13, City of Hope National Medical Center14, Yale University15
TL;DR: This study provided the first detailed analysis of risk factors for MF/SS and further investigation is needed to confirm these findings in prospective data and in other populations.
Abstract: Methods A pooled analysis of 324 MF/SS cases and 17 217 controls from 14 case–control studies from Europe, North America, and Australia, as part of the International Lymphoma Epidemiology Consortium (InterLymph) Non-Hodgkin Lymphoma (NHL) Subtypes Project, was carried out to investigate associations with lifestyle, medical history, family history, and occupational risk factors. Multivariate logistic regression models were used to calculate odds ratios (OR) and 95% confidence intervals (CI). Results We found an increased risk of MF/SS associated with body mass index equal to or larger than 30 kg/m 2 (OR = 1.57, 95% CI = 1.03 to 2.40), cigarette smoking for 40 years or more (OR = 1.55, 95% CI = 1.04 to 2.31), eczema (OR = 2.38, 95% CI = 1.73 to 3.29), family history of multiple myeloma (OR = 8.49, 95% CI = 3.31 to 21.80), and occupation as crop and vegetable farmers (OR = 2.37, 95% CI = 1.14 to 4.92), painters (OR = 3.71, 95% CI = 1.94 to 7.07), woodworkers (OR = 2.20, 95% CI = 1.18 to 4.08), and general carpenters (OR = 4.07, 95% CI = 1.54 to 10.75). We also found a reduced risk of MF/SS associated with moderate leisure time physical activity (OR = 0.46, 95% CI = 0.22 to 0.97).
43 citations
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42 citations
Authors
Showing all 1593 results
Name | H-index | Papers | Citations |
---|---|---|---|
Hans-Olov Adami | 145 | 908 | 83473 |
Melvin E. Andersen | 83 | 517 | 26856 |
Joseph Katz | 81 | 691 | 27793 |
Lorna J. Gibson | 75 | 178 | 33835 |
Buddhima Indraratna | 64 | 735 | 15596 |
Barbara A. Goff | 61 | 227 | 11859 |
Jack S. Mandel | 60 | 171 | 22308 |
Antonio Gens | 58 | 269 | 14987 |
Ellen T. Chang | 57 | 209 | 11567 |
Dayang Wang | 55 | 185 | 9513 |
Edmund Lau | 52 | 183 | 22520 |
Steven M. Kurtz | 52 | 249 | 8066 |
Alfred J. Crosby | 51 | 206 | 8310 |
Suresh H. Moolgavkar | 51 | 169 | 8833 |
Michael T. Halpern | 51 | 237 | 16566 |