Institution
Frankfurt Institute for Advanced Studies
Facility•Frankfurt am Main, Germany•
About: Frankfurt Institute for Advanced Studies is a facility organization based out in Frankfurt am Main, Germany. It is known for research contribution in the topics: Baryon & Quark–gluon plasma. The organization has 798 authors who have published 2733 publications receiving 82799 citations. The organization is also known as: FIAS.
Topics: Baryon, Quark–gluon plasma, Hadron, Quark, Quantum chromodynamics
Papers published on a yearly basis
Papers
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TL;DR: In this paper, the authors proposed a new energy management strategy to efficiently coordinate a hybrid energy storage system based on pumped hydro storage (long term bulk storage) with batteries (short term, more flexible).
87 citations
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TL;DR: In this article, a complete set of transport coefficients, consistent with the Curie and Onsager principles, is derived for thermal conduction, as well as shear and bulk viscosities.
87 citations
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TL;DR: MEP amplitude is modulated by μ-phase across a wide range of stimulation intensities, with larger MEPs at the surface negative peak, and results indicate a leftward shift of the MEP IO curve during the μ-rhythm negative peak.
87 citations
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TL;DR: It is demonstrated that cycles of fusion and fission and mitophagy indeed are essential for ensuring a high average quality of mitochondria, even under conditions in which random molecular damage is present, and proposed the MIDA model according to which a deceleration of fusion–fission cycles reflects a systemic adaptation increasing life span.
Abstract: Mitochondrial dynamics and mitophagy play a key role in ensuring mitochondrial quality control. Impairment thereof was proposed to be causative to neurodegenerative diseases, diabetes, and cancer. Accumulation of mitochondrial dysfunction was further linked to aging. Here we applied a probabilistic modeling approach integrating our current knowledge on mitochondrial biology allowing us to simulate mitochondrial function and quality control during aging in silico. We demonstrate that cycles of fusion and fission and mitophagy indeed are essential for ensuring a high average quality of mitochondria, even under conditions in which random molecular damage is present. Prompted by earlier observations that mitochondrial fission itself can cause a partial drop in mitochondrial membrane potential, we tested the consequences of mitochondrial dynamics being harmful on its own. Next to directly impairing mitochondrial function, pre-existing molecular damage may be propagated and enhanced across the mitochondrial population by content mixing. In this situation, such an infection-like phenomenon impairs mitochondrial quality control progressively. However, when imposing an age-dependent deceleration of cycles of fusion and fission, we observe a delay in the loss of average quality of mitochondria. This provides a rational why fusion and fission rates are reduced during aging and why loss of a mitochondrial fission factor can extend life span in fungi. We propose the ‘mitochondrial infectious damage adaptation’ (MIDA) model according to which a deceleration of fusion–fission cycles reflects a systemic adaptation increasing life span.
87 citations
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TL;DR: The NMR solution structure of the beta(E)-domain of the early cysteine-labeled protein from wheat is shown, which represents the first three-dimensional structure of a plant MT, and backbone dynamics investigated by (15)N relaxation experiments support the results of the structure determination.
87 citations
Authors
Showing all 809 results
Name | H-index | Papers | Citations |
---|---|---|---|
Wolf Singer | 124 | 580 | 72591 |
Peter Braun-Munzinger | 100 | 527 | 34108 |
R. Stock | 96 | 429 | 34877 |
G. Kozlov | 90 | 339 | 36161 |
Luciano Rezzolla | 90 | 394 | 26159 |
Walter Greiner | 84 | 1282 | 51857 |
Igor Pshenichnov | 83 | 362 | 22699 |
Xiaofeng Zhu | 80 | 1062 | 28158 |
Mikolaj Krzewicki | 77 | 284 | 18908 |
Ivan Kisel | 75 | 389 | 18330 |
David Edmund Johannes Linden | 74 | 361 | 18787 |
David Michael Rohr | 71 | 217 | 15111 |
Sergey Gorbunov | 71 | 258 | 15638 |
M. Bach | 71 | 123 | 14661 |
Miklos Gyulassy | 69 | 358 | 19140 |