Graduate University of Advanced Technology

About: Graduate University of Advanced Technology is a education organization based out in Kerman, Iran. It is known for research contribution in the topics: Carbon paste electrode & Electrochemical gas sensor. The organization has 890 authors who have published 2169 publications receiving 31027 citations.

Theoretical study of functionalized single-walled carbon nanotube (5, 5) with Mitoxantrone drug

Abstract: Objective(s): First principles calculations were performed to study four multiple sclerosis drugs namely, Ampyra, Fingolimod, Mitoxantrone and Eliprodil in gas and liquid phases using Density Functional Theory (DFT). Computational chemistry simulations were carried out to compare calculated quantum chemical parameters for Ampyra, Fingolimod, Mitoxantrone and Eliprodil. Materials and Methods: All calculations were performed using DMol3 code which is based on DFT. The Double Numerical basis set with Polarization functions (DNP) was used.Results: Mitoxantrone has highest HOMO energy, global softness, solvation energy and molecular mass and lowest LUMO energy, energy gap, global hardness and total energy in comparison to Ampyra, Fingolimod and Eliprodil in gas and solvent phases. Calculations were carried out to study the interaction of covalently binding Mitoxantrone to functionalized carbon nanotube. The Mitoxantrone local reactivity was studied through the Fukui indices in order to predict both the reactive centers and the possible sites of nucleophilic and electrophilic attacks. The Mitoxantrone binding energy is calculated to be 6.507 eV in gas phase and -9.943 eV in solvent phase that is a decrease in BE as the drug phase changes from gas to liquid.Conclusion: The simulation results show Mitoxantrone is quite a reactive drug. The quantum chemical parameters of pristine nanotube and f-SWNT-Mitoxantrone showed that reactivity of f-SWNT-Mitoxantrone increased in comparison to pristine nanotube in both phases.

Improvement of Building Resilience by Viscous Dampers

Abstract: In recent years, structural control strategies have been very important in earthquake and wind resistant designs in the world. In the classical period, structures were designed only for vertical loads. The modern period brought about dynamic calculation methods and applications. The current period, which can be regarded as the postmodern period, is based on the principle of controlling the behaviour of buildings with active and passive elements. The optimal location and size of these technological elements within a structure need to be determined. In this study, some methods of determining the optimum placement of viscous dampers, which are one of the most-known passive dampers, are summarised. Transfer functions for the optimisation of viscous dampers have been used in many studies, and many sophisticated methods have been proposed. In the methods mentioned in this study, while the location and amount of the dampers are investigated, the equations of motion are transformed into frequency domain, and the structural behaviours are given depending on the frequency and other structural parameters. Different objective functions; the sum of inter-storey drifts or top displacement, base shear force and top peak absolute acceleration are selected as the objective functions. In this study, the fundamental mode response of the structure is considered. The damping coefficients of the added dampers are design variables. The total damping coefficient is represented by an equality constraint, and there are some inequality constraints that represent the lower and upper limits of the damping coefficients of each added damper. Optimality conditions derived from the Lagrange Multipliers method are solved with the steepest direction search algorithm, and the optimum damper distribution is found. The designs for the different objective functions and the corresponding behaviours are compared. All optimum damper designs minimise their own objective functions. In a building design, optimum damper designs can be made using the objective function that corresponds to the most important behaviour. All designs show that the uniform design of the dampers is not better in terms of behaviour as well as construction and material cost, compared with the optimal designs.

Synthesis of graphene oxide nanosheets and its application to construct a modified carbon paste electrode as a hydroxylamine electrochemical sensor

Abstract: A ferrocene-derivative compound, 2, 7-bis (ferrocenyl ethynyl) fluoren-9-one (2,7-BFE), was synthesized and used to construct a modified graphene paste electrode. The electrooxidation of hydroxylamine at the surface of the modified electrode was studied using cyclic voltammetry (CV), chronoamperometry (CHA), and square wave voltammetry (SWV). Under the optimized conditions, the square wave voltammetric peak current of hydroxylamine increased linearly with hydroxylamine concentration in the range of 2.0 × 10−7 to 2.5 × 10−4 M and detection limit of 9.0 × 10−8 M was obtained for hydroxylamine. Finally, this modified electrode was used for determination of hydroxylamine in some water samples.

Effects of light emitting diode irradiation on neural differentiation of human umbilical cord-derived mesenchymal cells

Abstract: Recently, light emitting diodes (LEDs) have been introduced as a potential physical factor for proliferation and differentiation of various stem cells. Among the mesenchymal stem cells human umbilical cord matrix-derived mesenchymal (hUCM) cells are easily propagated in the laboratory and their low immunogenicity make them more appropriate for regenerative medicine procedures. We aimed at this study to evaluate the effect of red and green light emitted from LED on the neural lineage differentiation of hUCM cells in the presence or absence of retinoic acid (RA). Harvested hUCM cells exhibited mesenchymal and stemness properties. Irradiation of these cells by green and red LED with or without RA pre-treatment successfully differentiated them into neural lineage when the morphology of the induced cells, gene expression pattern (nestin, β-tubulin III and Olig2) and protein synthesis (anti-nestin, anti-β-tubulin III, anti-GFAP and anti-O4 antibodies) was evaluated. These data point for the first time to the fact that LED irradiation and optogenetic technology may be applied for neural differentiation and neuronal repair in regenerative medicine.

Collapse revival behaviour of the entanglement between V-type three-level atoms and two-mode photons in nonlinear Jaynes–Cummings model

Abstract: In this paper the time evolution of von Neumann entropy, as a measure of entanglement between V-type three-level atoms and the union of a two-mode field, is studied. The atom–field interaction is assumed to occur in a Kerr-type medium with an intensity-dependent coupling. Introducing a Casmir operator whose eigenvalues, N, give total excitations in the system and commutes with the governing Hamiltonian, it is concluded that the latter is block-diagonal with ever growing dimensions. As we shall show, however, each block consists of two 2 × 2 blocks while all the others, (N −1) in number, are 3 × 3. We then proceed to analytically calculate the time-evolution operator which is also block-diagonal, each block with the same properties as that of the Hamiltonian. Our calculations show that, as expected, the atom–field entanglement oscillates which, depending upon the initial state, exhibits the phenomenon of collapse revivals. It is further shown that collapse revivals occur whenever both 2 × 2 blocks are involved in the time evolution of the system. Properties of such behaviour in the entanglement are also discussed in detail.