Graduate University of Advanced Technology

About: Graduate University of Advanced Technology is a education organization based out in Kerman, Iran. It is known for research contribution in the topics: Carbon paste electrode & Electrochemical gas sensor. The organization has 890 authors who have published 2169 publications receiving 31027 citations.

Electrocatalytic Determination of Hydrazine and Phenol Using a Carbon Paste Electrode Modified with Ionic Liquids and Magnetic Core-shell Fe3O4@SiO2/MWCNT Nanocomposite

Abstract: A carbon paste electrode was modified with 2-(4-Oxo-3-phenyl-3,4-dihydroquinazolinyl)-N′-phenyl-hydrazinecarbothioamide, magnetic coreshell Fe3O4@SiO2/MWCNT nanocomposite and ionic liquid (n-hexyl-3-methylimidazolium hexafluoro phosphate). The electro-oxidation of hydrazine at the surface of the modified electrode was studied using electrochemical approaches. This modified electrode offers a considerable improvement in voltammetric sensitivity toward hydrazine, compared to the bare electrode. Square wave voltammetry (SWV) exhibits a linear dynamic range from 7.0×10−8 to 5.0×10−4 M and a detection limit of 40.0 nM for hydrazine. The diffusion coefficient and kinetic parameters (such as electron transfer coefficient and the heterogeneous rate constant) for hydrazine oxidation were also determined. The prepared modified electrode exhibits a very good resolution between the voltammetric peaks of hydrazine and phenol that makes it suitable for the detection of hydrazine in the presence of phenol in real samples.

A novel voltammetric sensor employing zinc oxide nanoparticles and a new ferrocene-derivative modified carbon paste electrode for determination of captopril in drug samples

Abstract: A novel 1,l′-bis(2-phenylethan-1-ol)ferrocene (1,1′-BEOF) is synthesized and used for the modification of a carbon paste electrode in the presence of ZnO nanoparticles (ZnO/NPs) as a sensor in captopril (CAP) drug determination. The new sensor shows excellent electrocatalytic activity for the electro-oxidation of CAP and reduction of charge transfer resistance. The square wave voltammogram (SWV) currents increase linearly with CAP concentration in the oxidation range of 0.09–450.0 μmol L−1 and the detection limit for CAP was 0.05 μmol L−1. The relative standard deviation for five successive assays of 10.0 μmol L−1 CAP was 1.9%. For further investigation, the novel sensor was employed for the determination of CAP in drug and urine samples.

Evaluation of Carum-loaded Niosomes on Breast Cancer Cells:Physicochemical Properties, In Vitro Cytotoxicity, Flow Cytometric, DNA Fragmentation and Cell Migration Assay.

Abstract: Thymoquinone (TQ), a phytochemical compound found in Carum carvil seeds (C. carvil), has a lot of applications in medical especially cancer therapy. However, TQ has a hydrophobic nature, and because of that, its solubility, permeability and its bioavailability in biological mediums are poor. To diminish these drawbacks, we have designed a herbal carrier composed of Ergosterol (herbal lipid), Carum carvil extract (Carum) and nonionic surfactants for herbal cancer treatment. C. carvil was extracted and characterized by GC/Mass. Two different formulations containing TQ and Carum were encapsulated into niosomes (Nio/TQ and Nio/Carum, respectively) and their properties were compared together. Morphology, size, zeta potential, encapsulation efficiency (EE%), profile release rate, in vitro cytotoxicity, flow cytometric, DNA fragmentation and cell migration assay of formulations were evaluated. Results show that both loaded formulations have a spherical morphology, nanometric size and negative zeta potential. EE% of TQ and Carum loaded niosomes was about 92.32% ± 2.32 and 86.25% ± 1.85, respectively. Both loaded formulations provided a controlled release compared with free TQ. MTT assay showed that loaded niosomes have more anti-cancer activity compared with Free TQ and free Carum against MCF-7 cancer cell line and these results were confirmed by flow cytometric analysis. Cell cycle analysis showed G2/M arrest in TQ, Nio/TQ and Nio/Carum formulations. TQ, Nio/TQ and Nio/Carum decreased the migration of MCF7 cells remarkedly. These results show that the TQ and Carum loaded niosomes are novel carriers with high efficiency for encapsulation of low soluble phytochemicals and also would be favourable systems for breast cancer treatment.