Graduate University of Advanced Technology

About: Graduate University of Advanced Technology is a education organization based out in Kerman, Iran. It is known for research contribution in the topics: Carbon paste electrode & Electrochemical gas sensor. The organization has 890 authors who have published 2169 publications receiving 31027 citations.

Assessment of changes in physiological and biochemical traits in four pistachio rootstocks under drought, salinity and drought + salinity stresses

Abstract: In this study, 7-month-old UCB-1, Badami, Ghazvini and Kale-Ghouchi pistachio rootstocks were exposed to control, drought, salinity and drought + salinity environments for 60 d. Total chlorophyll and total carotenoid contents decreased in all cultivars under drought, salinity and drought + salinity stresses. Under drought and salinity stresses, alone or in combination, Na+ and Cl- ions increased in all four pistachio rootstocks, while K+ ion decreased only in Ghazvini and Kaleh-Ghouchi cultivars. The enzyme activities of ascorbate peroxidase, polyphenol oxidase, catalase and guaiacol peroxidase increased in all cultivars when subjected to all three stresses with the exception of the ascorbate peroxidase activity in Kale-Ghouchi cultivar during drought stress. Oxidative stress parameters including electrolyte leakage, malondialdehyde, other aldehydes and hydrogen peroxide increased under all three stress conditions in all genotypes. The content of proline, total free amino acids and total soluble carbohydrates were enhanced under drought, salinity and drought + salinity stresses, whereas the protein content decreased in all pistachio rootstocks. In all evaluated traits, except for the K+ ion content and APX activity, the highest impacts was seen for drought + salinity > salinity > drought stresses, respectively. For the first time, we have proven that K+ ion content has a positive correlation with the ascorbate peroxidase, polyphenol oxidase, catalase and guaiacol peroxidase enzymes activities under drought + salinity stress. Finally, based on the bi-plot and cluster analyses, we have selected the UCB-1 > Badami > Ghazvini > Kale-Ghouchi cultivars as the most tolerant pistachio rootstocks under drought + salinity stress, respectively.

Magnetic delivery of antitumor carboplatin by using PEGylated-Niosomes

Abstract: To improve the efficiency of niosomal drug delivery, here we employed two tactics First, niosomes were magnetized using Fe3O4@SiO2 mangnetic nanoparticles, and second, their surface was modified by PEGylation PEGylation was intended for increasing the bioavailability of niosomes, and magnetization was used for rendering them capable of targeting specific tissues These PEGylated magnetic niosomes were also loaded with Carboplatin, an antitumor drug Next, these niosomes were studied in terms of size, morphology, zeta potential, and drug entrapment efficiency Then, the in vitro drug release from these modified niosomes was compared to that of both naked and nonmagnetized niosomes Interestingly, although loading of naked-niosomes with magnetic particles lead to an increase in the rate of drug release, PEGylation of these magnetized niosomes caused a more sustained drug release Thus, PEGylation of magnetic niosomes, besides improving their bioavailability, caused a slower and sustained release of the drug over time Finally, studying the in vitro effectives of niosomal formulations towards MCF-7, a breast cancer cell line, showed that PEGylated magnetic niosomes had a satisfactory toxicity towards these cells in the presence of an external magnetic field In conclusion, PEGylated magnetic niosomes showed enhanced qualities regarding the controlled release and delivery of drug

Ag nanoparticles decorated Fe 3 O 4 /chitosan nanocomposite: synthesis, characterization and application toward electrochemical sensing of hydrogen peroxide

Abstract: We studied a rapid, sensitive and selective amperometric sensor for determination of hydrogen peroxide by electrodeposited Ag NPs on a modified glassy carbon electrode (GCE). The modified GCE was constructed through a step by step modification of magnetic chitosan functional composite (Fe3O4–CH) and high-dispersed silver nanoparticles on the surface. The resulted Ag@Fe3O4–CH was characterized by various analytical methods including Fourier transform infrared spectroscopy, X-ray diffraction, transmission electron microscopy, scanning electron microscopy and cyclic voltammetry. The proposed sensor employed Ag@Fe3O4–CH/GCE as the working electrode with a linear current response to the hydrogen peroxide concentration in a wide range from 0.01 to 400 µM with a low limit of detection (LOD = 0.0038 µM, S/N = 3). The proposed sensor showed superior reproductivity, sensitivity and selectivity for the detection of hydrogen peroxide in environmental and clinical samples.