I.M. Sechenov First Moscow State Medical University

About: I.M. Sechenov First Moscow State Medical University is a education organization based out in Moscow, Russia. It is known for research contribution in the topics: Medicine & Population. The organization has 7984 authors who have published 9355 publications receiving 68997 citations.

Antibodies in serum of convalescent patients following mild COVID-19 do not always prevent virus-receptor binding.

Abstract: In order to investigate whether COVID-19 convalescent patients have developed antibodies that may protect from reinfection, we collected sera from COVID-19 convalescent patients approximately 10 weeks after confirmation of COVID-19 by qRT-PCR (group B, n = 25, 11 females, 14 males, age range: 18-70 years, median age 52.2) and included for control purposes sera from subjects obtained before the COVID-19 pandemic (historic control group P, n = 24, 13 females, 11 males, age range: 18-68 years, median age 43.2). Our findings suggest that a natural SARS-CoV-2 infection, similar to that observed previously for rhinovirus (RV) infections,9 does not induce a protective antibody response inhibiting the virus-receptor interaction in all infected patients and therefore underline the urgent need for the development of a SARS-CoV-2 vaccine. The molecular interaction assays could be useful for identifying subjects having developed protective antibodies and for screening candidate vaccines to induce antibodies that inhibit the RBD-ACE2 interaction once they have been validated.

Molecular Approaches for Diagnosis, Therapy and Prevention of Cow’s Milk Allergy

Abstract: Cow’s milk is one of the most important and basic nutrients introduced early in life in our diet but can induce IgE-associated allergy. IgE-associated allergy to cow’s milk can cause severe allergic manifestations in the gut, skin and even in the respiratory tract and may lead to life-threatening anaphylactic shock due to the stability of certain cow’s milk allergens. Here, we provide an overview about the allergen molecules in cow’s milk and the advantages of the molecular diagnosis of IgE sensitization to cow’s milk by serology. In addition, we review current strategies for prevention and treatment of cow’s milk allergy and discuss how they could be improved in the future by innovative molecular approaches that are based on defined recombinant allergens, recombinant hypoallergenic allergen derivatives and synthetic peptides.

The advances and limitations in biodiesel production: feedstocks, oil extraction methods, production, and environmental life cycle assessment

Abstract: Although fossil fuels remain the main source of energy, the volume of renewable sources of energy is constantly increasing. Biodiesel is a promising alternative fuel due to the number of advantages...