Showing papers by "I.M. Sechenov First Moscow State Medical University published in 2020"
TL;DR: Global health has steadily improved over the past 30 years as measured by age-standardised DALY rates, and there has been a marked shift towards a greater proportion of burden due to YLDs from non-communicable diseases and injuries.
5,802 citations
Christopher J L Murray1, Christopher J L Murray2, Christopher J L Murray3, Aleksandr Y. Aravkin3 +2269 more•Institutions (286)
TL;DR: The largest declines in risk exposure from 2010 to 2019 were among a set of risks that are strongly linked to social and economic development, including household air pollution; unsafe water, sanitation, and handwashing; and child growth failure.
3,059 citations
TL;DR: Cardiac magnetic resonance imaging revealed cardiac involvement and ongoing myocardial inflammation in patients with recent coronavirus disease 2019, which was independent of preexisting conditions, severity and overall course of the acute illness, and the time from the original diagnosis.
Abstract: Importance Coronavirus disease 2019 (COVID-19) continues to cause considerable morbidity and mortality worldwide. Case reports of hospitalized patients suggest that COVID-19 prominently affects the cardiovascular system, but the overall impact remains unknown. Objective To evaluate the presence of myocardial injury in unselected patients recently recovered from COVID-19 illness. Design, Setting, and Participants In this prospective observational cohort study, 100 patients recently recovered from COVID-19 illness were identified from the University Hospital Frankfurt COVID-19 Registry between April and June 2020. Exposure Recent recovery from severe acute respiratory syndrome coronavirus 2 infection, as determined by reverse transcription–polymerase chain reaction on swab test of the upper respiratory tract. Main Outcomes and Measures Demographic characteristics, cardiac blood markers, and cardiovascular magnetic resonance (CMR) imaging were obtained. Comparisons were made with age-matched and sex-matched control groups of healthy volunteers (n = 50) and risk factor–matched patients (n = 57). Results Of the 100 included patients, 53 (53%) were male, and the mean (SD) age was 49 (14) years. The median (IQR) time interval between COVID-19 diagnosis and CMR was 71 (64-92) days. Of the 100 patients recently recovered from COVID-19, 67 (67%) recovered at home, while 33 (33%) required hospitalization. At the time of CMR, high-sensitivity troponin T (hsTnT) was detectable (greater than 3 pg/mL) in 71 patients recently recovered from COVID-19 (71%) and significantly elevated (greater than 13.9 pg/mL) in 5 patients (5%). Compared with healthy controls and risk factor–matched controls, patients recently recovered from COVID-19 had lower left ventricular ejection fraction, higher left ventricle volumes, and raised native T1 and T2. A total of 78 patients recently recovered from COVID-19 (78%) had abnormal CMR findings, including raised myocardial native T1 (n = 73), raised myocardial native T2 (n = 60), myocardial late gadolinium enhancement (n = 32), or pericardial enhancement (n = 22). There was a small but significant difference between patients who recovered at home vs in the hospital for native T1 mapping (median [IQR], 1119 [1092-1150] ms vs 1141 [1121-1175] ms;P = .008) and hsTnT (4.2 [3.0-5.9] pg/dL vs 6.3 [3.4-7.9] pg/dL;P = .002) but not for native T2 mapping. None of these measures were correlated with time from COVID-19 diagnosis (native T1:r = 0.07;P = .47; native T2:r = 0.14;P = .15; hsTnT:r = −0.07;P = .50). High-sensitivity troponin T was significantly correlated with native T1 mapping (r = 0.33;P Conclusions and Relevance In this study of a cohort of German patients recently recovered from COVID-19 infection, CMR revealed cardiac involvement in 78 patients (78%) and ongoing myocardial inflammation in 60 patients (60%), independent of preexisting conditions, severity and overall course of the acute illness, and time from the original diagnosis. These findings indicate the need for ongoing investigation of the long-term cardiovascular consequences of COVID-19.
1,576 citations
Joan B. Soriano1, Parkes J Kendrick2, Katherine R. Paulson2, Vinay Gupta2 +311 more•Institutions (178)
TL;DR: It is shown that chronic respiratory diseases remain a leading cause of death and disability worldwide, with growth in absolute numbers but sharp declines in several age-standardised estimators since 1990.
829 citations
TL;DR: The heterologous rAd26 and rAd5 vector-based COVID-19 vaccine has a good safety profile and induced strong humoral and cellular immune responses in participants and was safe and well tolerated.
783 citations
University of Duisburg-Essen1, University of Düsseldorf2, Harvard University3, University of Warsaw4, University of Melbourne5, St. Vincent's Institute of Medical Research6, Johns Hopkins University7, Swiss Institute of Bioinformatics8, Western General Hospital9, The Turing Institute10, BC Cancer Agency11, University of British Columbia12, ETH Zurich13, Delft University of Technology14, Leiden University Medical Center15, Broad Institute16, Georgia State University17, Karlsruhe Institute of Technology18, Heidelberg Institute for Theoretical Studies19, Centrum Wiskunde & Informatica20, Utrecht University21, University of Amsterdam22, Imperial College London23, Radboud University Nijmegen24, University Medical Center Groningen25, Wageningen University and Research Centre26, University of Connecticut27, Wellcome Trust Sanger Institute28, European Bioinformatics Institute29, University of Cambridge30, Saarland University31, Max Planck Society32, Zuse Institute Berlin33, German Cancer Research Center34, Leiden University35, I.M. Sechenov First Moscow State Medical University36, Princeton University37, Memorial Sloan Kettering Cancer Center38
TL;DR: This compendium is for established researchers, newcomers, and students alike, highlighting interesting and rewarding problems for the coming years in single-cell data science.
Abstract: The recent boom in microfluidics and combinatorial indexing strategies, combined with low sequencing costs, has empowered single-cell sequencing technology. Thousands-or even millions-of cells analyzed in a single experiment amount to a data revolution in single-cell biology and pose unique data science problems. Here, we outline eleven challenges that will be central to bringing this emerging field of single-cell data science forward. For each challenge, we highlight motivating research questions, review prior work, and formulate open problems. This compendium is for established researchers, newcomers, and students alike, highlighting interesting and rewarding problems for the coming years.
677 citations
Duke University1, Pontifical Catholic University of Chile2, University of Florida3, Veterans Health Administration4, Kaiser Permanente5, University of Pennsylvania6, University of Amsterdam7, Harvard University8, University of California, Davis9, McMaster University10, I.M. Sechenov First Moscow State Medical University11, Washington University in St. Louis12, Katholieke Universiteit Leuven13, University of Utah14, University of Antioquia15
TL;DR: Recommendations include the use of thrombolytic therapy for patients with PE and hemodynamic compromise, use of an international normalized ratio (INR) range, and a preference for direct oral anticoagulants over VKA for primary treatment of VTE.
497 citations
TL;DR: The importance of an optimal status of relevant nutrients to effectively reduce inflammation and oxidative stress, thereby strengthening the immune system during the COVID-19 crisis is highlighted.
Abstract: The coronavirus-disease 2019 (COVID-19) was announced as a global pandemic by the World Health Organization. Challenges arise concerning how to optimally support the immune system in the general population, especially under self-confinement. An optimal immune response depends on an adequate diet and nutrition in order to keep infection at bay. For example, sufficient protein intake is crucial for optimal antibody production. Low micronutrient status, such as of vitamin A or zinc, has been associated with increased infection risk. Frequently, poor nutrient status is associated with inflammation and oxidative stress, which in turn can impact the immune system. Dietary constituents with especially high anti-inflammatory and antioxidant capacity include vitamin C, vitamin E, and phytochemicals such as carotenoids and polyphenols. Several of these can interact with transcription factors such as NF-kB and Nrf-2, related to anti-inflammatory and antioxidant effects, respectively. Vitamin D in particular may perturb viral cellular infection via interacting with cell entry receptors (angiotensin converting enzyme 2), ACE2. Dietary fiber, fermented by the gut microbiota into short-chain fatty acids, has also been shown to produce anti-inflammatory effects. In this review, we highlight the importance of an optimal status of relevant nutrients to effectively reduce inflammation and oxidative stress, thereby strengthening the immune system during the COVID-19 crisis.
445 citations
TL;DR: A new strain of coronavirus infection emerged in Wuhan, China the SARS-CoV-2 or the Covid-19 as mentioned in this paper, which is characterized by fever, dry cough, myalgia and extreme fatigue.
414 citations
TL;DR: Signs suggest that zinc status may possess protective effect as preventive and adjuvant therapy of COVID-19 through reducing inflammation, improvement of mucociliary clearance, prevention of ventilator-induced lung injury, modulation of antiviral and antibacterial immunity.
Abstract: In view of the emerging COVID-19 pandemic caused by SARS-CoV-2 virus, the search for potential protective and therapeutic antiviral strategies is of particular and urgent interest. Zinc is known to modulate antiviral and antibacterial immunity and regulate inflammatory response. Despite the lack of clinical data, certain indications suggest that modulation of zinc status may be beneficial in COVID-19. In vitro experiments demonstrate that Zn2+ possesses antiviral activity through inhibition of SARS-CoV RNA polymerase. This effect may underlie therapeutic efficiency of chloroquine known to act as zinc ionophore. Indirect evidence also indicates that Zn2+ may decrease the activity of angiotensin-converting enzyme 2 (ACE2), known to be the receptor for SARS-CoV-2. Improved antiviral immunity by zinc may also occur through up-regulation of interferon α production and increasing its antiviral activity. Zinc possesses anti-inflammatory activity by inhibiting NF-κB signaling and modulation of regulatory T-cell functions that may limit the cytokine storm in COVID-19. Improved Zn status may also reduce the risk of bacterial co-infection by improving mucociliary clearance and barrier function of the respiratory epithelium, as well as direct antibacterial effects against S. pneumoniae. Zinc status is also tightly associated with risk factors for severe COVID-19 including ageing, immune deficiency, obesity, diabetes, and atherosclerosis, since these are known risk groups for zinc deficiency. Therefore, Zn may possess protective effect as preventive and adjuvant therapy of COVID-19 through reducing inflammation, improvement of mucociliary clearance, prevention of ventilator-induced lung injury, modulation of antiviral and antibacterial immunity. However, further clinical and experimental studies are required.
332 citations
25 Sep 2020
TL;DR: Venous thromboembolism is frequently observed in patients with coronavirus disease 2019 (COVID‐19), however, reported VTE rates differ substantially.
Abstract: Background Venous thromboembolism (VTE) is frequently observed in patients with coronavirus disease 2019 (COVID-19). However, reported VTE-rates differ substantially. Objectives We aimed at evaluating available data and estimating the prevalence of VTE in COVID-19 patients. Methods We conducted a systematic literature search (MEDLINE, EMBASE, WHO COVID-19 database) to identify studies reporting VTE-rates in COVID-19 patients. Studies with suspected high risk of bias were excluded from quantitative synthesis. Pooled outcome rates were obtained within a random effects meta-analysis. Subgroup analyses were performed for different settings (intensive care unit (ICU) vs. non-ICU hospitalization and screening vs. no screening) and the association of D-dimer levels and VTE-risk was explored. Results Eighty-six studies (33,970 patients) were identified and 66 (28,173 patients, mean age: 62.6 years, 60% men, 20% ICU-patients) were included in quantitative analysis. The overall VTE-prevalence estimate was 14.1% (95%CI 11.6-16.9), 40.3% (95%CI 27.0-54.3) with ultrasound-screening and 9.5% (95%CI 7.5-11.7) without screening. Subgroup analysis revealed high heterogeneity, with a VTE-prevalence of 7.9% (95%CI 5.1-11.2) in non-ICU and 22.7% (95%CI 18.1-27.6) in ICU patients. Prevalence of pulmonary embolism (PE) in non-ICU and ICU patients was 3.5% (95%CI 2.2-5.1) and 13.7% (95%CI 10.0-17.9). Patients developing VTE had higher D-dimer levels (weighted mean difference 3.26 µg/ml (95%CI 2.76-3.77) than non-VTE patients. Conclusion VTE occurs in 22.7% of patients with COVID-19 in the ICU, but VTE risk is also increased in non-ICU hospitalized patients. Patients developing VTE had higher D-dimer levels. Studies evaluating thromboprophylaxis strategies in patients with COVID-19 are needed to improve prevention of VTE.
TL;DR: To assess current trajectories towards the GPW13 UHC billion target—1 billion more people benefiting from UHC by 2023—the authors estimated additional population equivalents with UHC effective coverage from 2018 to 2023, and quantified frontiers of U HC effective coverage performance on the basis of pooled health spending per capita.
TL;DR: This review focuses on the recent liposome' preparation techniques, the excipients of liposomal formulations used in various novel studies and the routes of administration used to deliver liposomes to targeted areas of disease.
TL;DR: Cyclodextrin is a relatively low cost, biocompatible, biodegradable, and highly explored material with low toxicity for drug formulation, drug delivery, and wide varieties of other biomedical applications such as those in medical devices fabrication, biosensor, tissue engineering, and bio‐imaging.
Abstract: J.W., N.G.K., and S.G. contributed equally to this work. This project received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska‐Curie grant agreement No 713690. This publication was also emanated from research conducted with the financial support of Science Foundation Ireland (SFI) and is co‐funded under the European Regional Development Fund under Grant Number 13/RC/2073. S.G. would like to thank India's Ministry of Chemicals and Fertilizers for NIPER Ph.D. fellowship. The authors would also like to thank Maciej Doczyk for his help with the graphic illustrations and Anthony Sloan (Technical Writer‐English) for his careful help in finalizing the manuscript.
Humanitas University1, University of Cartagena2, University of Genoa3, Hebron University4, University of Veterinary Medicine Vienna5, University of Helsinki6, Autonomous University of Barcelona7, University of Paris8, University of Montpellier9, Erasmus University Rotterdam10, Universidad Autónoma de Nuevo León11, Mayo Clinic12, Kırıkkale University13, University of São Paulo14, University of South Florida15, San Juan de Dios Educational Foundation16, University of Marburg17, Nippon Medical School18, Federal University of Paraná19, University of Missouri–Kansas City20, Royal Children's Hospital21, Tan Tock Seng Hospital22, I.M. Sechenov First Moscow State Medical University23, Medical University of Vienna24, Johns Hopkins University School of Medicine25, Charité26
TL;DR: A thorough and updated critical appraisal of the most frequently used diagnostic tests, both in vivo and in vitro, and discusses skin tests, challenges, and serological and cellular in vitro tests, and provides an overview of indications, advantages and disadvantages of each in conditions such as respiratory, food, venom, drug, and occupational allergy.
Vilnius University1, Charles University in Prague2, Hospital Universitario La Paz3, National and Kapodistrian University of Athens4, National Institutes of Health5, Medical University of Vienna6, University of Paris7, University of Cyprus8, University of Göttingen9, American Heart Institute10, Uppsala University11, Lithuanian University of Health Sciences12, University of Bern13, University Medical Center Groningen14, Charité15, Tel Aviv University16, Clalit Health Services17, University of Bristol18, I.M. Sechenov First Moscow State Medical University19, University of Liège20, Leiden University21, Baker IDI Heart and Diabetes Institute22, Utrecht University23, Linköping University24, University of Parma25, Hannover Medical School26, Queen Mary University of London27, Katholieke Universiteit Leuven28, Maastricht University29, University Hospital of Basel30, University of Zurich31, Carlos III Health Institute32, Serbian Academy of Sciences and Arts33, Oslo University Hospital34, University of Oslo35
TL;DR: The role of echocardiographic parameters, including global longitudinal strain and three‐dimensional ejection fraction, are proposed and the protocol for baseline pre‐treatment evaluation and specific surveillance algorithms or pathways for anthracycline chemotherapy, HER2‐targeted therapies such as trastuzumab and vascular endothelial growth factor tyrosine kinase inhibitors are presented.
Abstract: Cardiovascular (CV) imaging is an important tool in baseline risk assessment and detection of CV disease in oncology patients receiving cardiotoxic cancer therapies. This position statement examines the role of echocardiography, cardiac magnetic resonance, nuclear cardiac imaging and computed tomography in the management of cancer patients. The Imaging and Cardio-Oncology Study Groups of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC) in collaboration with the European Association of Cardiovascular Imaging (EACVI) and the Cardio-Oncology Council of the ESC have evaluated the current evidence for the value of modern CV imaging in the cardio-oncology field. The most relevant echocardiographic parameters, including global longitudinal strain and three-dimensional ejection fraction, are proposed. The protocol for baseline pre-treatment evaluation and specific surveillance algorithms or pathways for anthracycline chemotherapy, HER2-targeted therapies such as trastuzumab, vascular endothelial growth factor tyrosine kinase inhibitors, BCr-Abl tyrosine kinase inhibitors, proteasome inhibitors and immune checkpoint inhibitors are presented. The indications for CV imaging after completion of oncology treatment are considered. The typical consequences of radiation therapy and the possibility of their identification in the long term are also summarized. Special populations are discussed including female survivors planning pregnancy, patients with carcinoid disease, patients with cardiac tumours and patients with right heart failure. Future directions and ongoing CV imaging research in cardio-oncology are discussed.
NewYork–Presbyterian Hospital1, Yale University2, University of Alcalá3, Harvard University4, Beth Israel Deaconess Medical Center5, University of Insubria6, University of Texas Health Science Center at Houston7, University of Liverpool8, Chinese PLA General Hospital9, Huazhong University of Science and Technology10, Jean Monnet University11, Hospital of the University of Pennsylvania12, Leonard Davis Institute of Health Economics13, Veterans Health Administration14, University of Vermont15, University of Montpellier16, Westmead Hospital17, Loyola University Medical Center18, NorthShore University HealthSystem19, University of Chicago20, University of Milan21, Auckland City Hospital22, St Thomas' Hospital23, Hofstra University24, University of Michigan25, Population Health Research Institute26, I.M. Sechenov First Moscow State Medical University27, McMaster University28, Ottawa Hospital Research Institute29, Brigham and Women's Hospital30, Vanderbilt University31, Icahn School of Medicine at Mount Sinai32, University of Cologne33, Universidad Católica San Antonio de Murcia34, University of Mainz35, Aalborg University36
TL;DR: Novel dosing approaches are described for commonly used antithrombotic agents (especially heparin-based regimens) and the potential use of less widely used antithsombotic drugs in the absence of confirmed thrombosis.
Abstract: Coronavirus disease 2019 (COVID-19), currently a worldwide pandemic, is a viral illness caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The suspected contribution of thrombotic events to morbidity and mortality in COVID-19 patients has prompted a search for novel potential options for preventing COVID-19-associated thrombotic disease. In this article by the Global COVID-19 Thrombosis Collaborative Group, we describe novel dosing approaches for commonly used antithrombotic agents (especially heparin-based regimens) and the potential use of less widely used antithrombotic drugs in the absence of confirmed thrombosis. Although these therapies may have direct antithrombotic effects, other mechanisms of action, including anti-inflammatory or antiviral effects, have been postulated. Based on survey results from this group of authors, we suggest research priorities for specific agents and subgroups of patients with COVID-19. Further, we review other agents, including immunomodulators, that may have antithrombotic properties. It is our hope that the present document will encourage and stimulate future prospective studies and randomized trials to study the safety, efficacy, and optimal use of these agents for prevention or management of thrombosis in COVID-19.
TL;DR: It is concluded, that research of thermoresponsive polymers has made big progress in recent years, especially for PNIPAm since the 1990s, and manifold research possibilities, e.g. in surface fabrication and 3D-printing and further translational applications are conceivable in near future.
Abstract: Thermoresponsive polymers hold great potential in the biomedical field, since they enable the fabrication of cell sheets, in situ drug delivery and 3D-printing under physiological conditions. In this review we provide an overview of several thermoresponsive polymers and their application, with focus on poly(N-isopropylacrylamide)-surfaces for cell sheet engineering. Basic knowledge of important processes like protein adsorption on surfaces and cell adhesion is provided. For different thermoresponsive polymers, namely PNIPAm, Pluronics, elastin-like polypeptides (ELP) and poly(N-vinylcaprolactam) (PNVCL), synthesis and basic chemical and physical properties have been described and the mechanism of their thermoresponsive behavior highlighted. Fabrication methods of thermoresponsive surfaces have been discussed, focusing on PNIPAm, and describing several methods in detail. The latter part of this review is dedicated to the application of the thermoresponsive polymers and with regard to cell sheet engineering, the process of temperature-dependent cell sheet detachment is explained. We provide insight into several applications of PNIPAm surfaces in cell sheet engineering. For Pluronics, ELP and PNVCL we show their application in the field of drug delivery and tissue engineering. We conclude, that research of thermoresponsive polymers has made big progress in recent years, especially for PNIPAm since the 1990s. However, manifold research possibilities, e.g. in surface fabrication and 3D-printing and further translational applications are conceivable in near future.
TL;DR: This study comparatively analyzed the peptide sharing between SARS-CoV-2 and mammalian species and found that different levels/ patterns of molecular mimicry vs. the virus should characterize the various animal species.
Abstract: The ethiopathology of the diseasome induced by the SARSCoV-2 infection in the human host [1] is under intensive investigation. A likely mechanism is that the multitude of the diseases encompassed within COVID-19 derives frommolecular mimicry phenomena between the virus and human proteins [2]. The rationale is that, following an infection, the immune responses raised against the pathogen can crossreact with human proteins that share peptide sequences (or structures) with the pathogen, in this way, leading to harmful autoimmune pathologies [3, 4]. Accordingly, lungs and airways dysfunctions associated with SARS-CoV-2 infection might be explained by the sharing of peptides between SARS-CoV-2 spike glycoprotein and alveolar lung surfactant proteins [2]. In support of this thesis, additional reports [5–8] highlight molecular mimicry and cross-reactivity as capable of explaining the SARS-CoV diseases. Of special interest, crossreactive T cell recognition between circulating “common cold” coronaviruses and SARS-CoV-2 has been also suggested [9]. In this scientific framework, this study comparatively analyzed the peptide sharing between SARS-CoV-2 and mammalian species. Our reasoning is that if it were true that molecular mimicry between SARS-CoV-2 and human proteins contributes to or causes COVID-19, then different levels/ patterns of molecular mimicry vs. the virus should characterize the various animal species. Indeed, scarce data exist to indicate that domestic animals, for instances dogs and cats, can either transmit the virus or develop the virus-associated diseasome [10]. In general, currently, the consensus remains that there is no evidence that infected pets are a source of SARS-CoV-2 infection for people or other pets [11, 12]. Based on this rationale and using hexaand heptapeptides as sequence probes [13–15], the peptide overlap between SARS-CoV-2 spike glycoprotein and mammalian proteomes was analyzed.
TL;DR: The main objective of this review was to elucidate the reaction pathways that underlie the ABTS/potassium persulfate decolorization assay of antioxidant capacity and recommend ABTS-based assays with certain reservations, particularly for tracking changes in the same antioxidant system during storage and processing.
Abstract: The 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS•+) radical cation-based assays are among the most abundant antioxidant capacity assays, together with the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-based assays according to the Scopus citation rates. The main objective of this review was to elucidate the reaction pathways that underlie the ABTS/potassium persulfate decolorization assay of antioxidant capacity. Comparative analysis of the literature data showed that there are two principal reaction pathways. Some antioxidants, at least of phenolic nature, can form coupling adducts with ABTS•+, whereas others can undergo oxidation without coupling, thus the coupling is a specific reaction for certain antioxidants. These coupling adducts can undergo further oxidative degradation, leading to hydrazindyilidene-like and/or imine-like adducts with 3-ethyl-2-oxo-1,3-benzothiazoline-6-sulfonate and 3-ethyl-2-imino-1,3-benzothiazoline-6-sulfonate as marker compounds, respectively. The extent to which the coupling reaction contributes to the total antioxidant capacity, as well as the specificity and relevance of oxidation products, requires further in-depth elucidation. Undoubtedly, there are questions as to the overall application of this assay and this review adds to them, as specific reactions such as coupling might bias a comparison between antioxidants. Nevertheless, ABTS-based assays can still be recommended with certain reservations, particularly for tracking changes in the same antioxidant system during storage and processing.
TL;DR: The usefulness of early micronutrient intervention, with focus on zinc, selenium, and vitamin D, to relieve escalation of COVID-19 is explored and initiation of adequate supplementation in high-risk areas and/or soon after the time of suspected infection with SARS-CoV-2 is recommended.
Abstract: Objectives: The novel coronavirus infection (COVID-19) conveys a serious threat globally to health and economy because of a lack of vaccines and specific treatments. A common factor for conditions that predispose for serious progress is a low-grade inflammation, e.g., as seen in metabolic syndrome, diabetes, and heart failure, to which micronutrient deficiencies may contribute. The aim of the present article was to explore the usefulness of early micronutrient intervention, with focus on zinc, selenium, and vitamin D, to relieve escalation of COVID-19. Methods: We conducted an online search for articles published in the period 2010–2020 on zinc, selenium, and vitamin D, and corona and related virus infections. Results: There were a few studies providing direct evidence on associations between zinc, selenium, and vitamin D, and COVID-19. Adequate supply of zinc, selenium, and vitamin D is essential for resistance to other viral infections, immune function, and reduced inflammation. Hence, it is suggested that nutrition intervention securing an adequate status might protect against the novel coronavirus SARS-CoV-2 (Severe Acute Respiratory Syndrome - coronavirus-2) and mitigate the course of COVID-19. Conclusion: We recommended initiation of adequate supplementation in high-risk areas and/or soon after the time of suspected infection with SARS-CoV-2. Subjects in high-risk groups should have high priority as regards this nutritive adjuvant therapy, which should be started prior to administration of specific and supportive medical measures.
TL;DR: Nano-curcumin, as an anti-inflammatory herbal based agent, may be able to modulate the increased rate of inflammatory cytokines especially IL-1β and IL-6 mRNA expression and cytokine secretion in COVID-19 patients, which may cause an improvement in clinical manifestation and overall recovery.
I.M. Sechenov First Moscow State Medical University1, University of Oxford2, King's College London3, Kaiser Permanente4, Jichi Medical University5, University Health Network6, University of Colorado Boulder7, University of Edinburgh8, HealthPartners9, University of Milano-Bicocca10, University of Missouri11
TL;DR: The best proposed healthcare model for telemedicine in hypertension management should include remote monitoring and transmission of vital signs and medication adherence plus education on lifestyle and risk factors, with video consultation as an option.
Abstract: Telemedicine allows the remote exchange of medical data between patients and healthcare professionals. It is used to increase patients' access to care and provide effective healthcare services at a distance. During the recent coronavirus disease 2019 (COVID-19) pandemic, telemedicine has thrived and emerged worldwide as an indispensable resource to improve the management of isolated patients due to lockdown or shielding, including those with hypertension. The best proposed healthcare model for telemedicine in hypertension management should include remote monitoring and transmission of vital signs (notably blood pressure) and medication adherence plus education on lifestyle and risk factors, with video consultation as an option. The use of mixed automated feedback services with supervision of a multidisciplinary clinical team (physician, nurse, or pharmacist) is the ideal approach. The indications include screening for suspected hypertension, management of older adults, medically underserved people, high-risk hypertensive patients, patients with multiple diseases, and those isolated due to pandemics or national emergencies.
TL;DR: Efficiency enhancements and quality improvements in products (and extracts) using ultrasound are discussed in terms of mechanism and principles for a range of food-matrix categories, while efforts to improve existing ultrasound-assist patterns was also seen.
TL;DR: In this article, a review analyzes information on the oxidative stress associated with the infections caused by SARS-CoV-2 and other respiratory viruses and focuses on involvement of the vascular endothelium in the COVID-19 pathogenesis.
Abstract: Pathogenesis of the novel coronavirus infection COVID-19 is the subject of active research around the world. COVID-19 caused by the SARS-CoV-2 is a complex disease in which interaction of the virus with target cells, action of the immune system and the body’s systemic response to these events are closely intertwined. Many respiratory viral infections, including COVID-19, cause death of the infected cells, activation of innate immune response, and secretion of inflammatory cytokines. All these processes are associated with the development of oxidative stress, which makes an important contribution to pathogenesis of the viral infections. This review analyzes information on the oxidative stress associated with the infections caused by SARS-CoV-2 and other respiratory viruses. The review also focuses on involvement of the vascular endothelium in the COVID-19 pathogenesis.
TL;DR: The pathogenic role of ferritin and iron during SARS-CoV-2 infection is analysed and iron depletion therapy is proposed as a novel therapeutic approach in the COVID-19 pandemic.
Abstract: SARS-CoV-2 infection is characterized by a protean clinical picture that can range from asymptomatic patients to life-threatening conditions. Severe COVID-19 patients often display a severe pulmonary involvement and develop neutrophilia, lymphopenia, and strikingly elevated levels of IL-6. There is an over-exuberant cytokine release with hyperferritinemia leading to the idea that COVID-19 is part of the hyperferritinemic syndrome spectrum. Indeed, very high levels of ferritin can occur in other diseases including hemophagocytic lymphohistiocytosis, macrophage activation syndrome, adult-onset Still's disease, catastrophic antiphospholipid syndrome and septic shock. Numerous studies have demonstrated the immunomodulatory effects of ferritin and its association with mortality and sustained inflammatory process. High levels of free iron are harmful in tissues, especially through the redox damage that can lead to fibrosis. Iron chelation represents a pillar in the treatment of iron overload. In addition, it was proven to have an anti-viral and anti-fibrotic activity. Herein, we analyse the pathogenic role of ferritin and iron during SARS-CoV-2 infection and propose iron depletion therapy as a novel therapeutic approach in the COVID-19 pandemic.
Hospital Sant Joan de Déu Barcelona1, Swiss Institute of Allergy and Asthma Research2, University Hospital Southampton NHS Foundation Trust3, St Mary's Hospital4, University of Southampton5, Medical University of Graz6, CEU San Pablo University7, Carlos III Health Institute8, Istanbul Medeniyet University9, University of Pisa10, I.M. Sechenov First Moscow State Medical University11, Charité12, National Institutes of Health13, Odense University Hospital14, Istanbul University15, University of Padua16, University of Messina17, University of Marburg18, Imperial College London19
TL;DR: This user's guide reviews current knowledge and aims to provide clinical guidance to healthcare professionals taking care of children undergoing allergen immunotherapy to improve the patient's adherence to the treatment.
Abstract: Allergen immunotherapy is a cornerstone in the treatment of allergic children. The clinical efficiency relies on a well-defined immunologic mechanism promoting regulatory T cells and downplaying the immune response induced by allergens. Clinical indications have been well documented for respiratory allergy in the presence of rhinitis and/or allergic asthma, to pollens and dust mites. Patients who have had an anaphylactic reaction to hymenoptera venom are also good candidates for allergen immunotherapy. Administration of allergen is currently mostly either by subcutaneous injections or by sublingual administration. Both methods have been extensively studied and have pros and cons. Specifically in children, the choice of the method of administration according to the patient's profile is important. Although allergen immunotherapy is widely used, there is a need for improvement. More particularly, biomarkers for prediction of the success of the treatments are needed. The strength and efficiency of the immune response may also be boosted by the use of better adjuvants. Finally, novel formulations might be more efficient and might improve the patient's adherence to the treatment. This user's guide reviews current knowledge and aims to provide clinical guidance to healthcare professionals taking care of children undergoing allergen immunotherapy.
Yaroslavl State University1, Peoples' Friendship University of Russia2, I.M. Sechenov First Moscow State Medical University3, Assiut University4, Razi Vaccine and Serum Research Institute5, University of Veterinary and Pharmaceutical Sciences Brno6, Ljubljana University Medical Centre7, University of Concepción8, Jazan University9, Lodz University of Technology10, University of Łódź11, University of Verona12
TL;DR: Early assessment and treatment of antioxidant status may result in a better prognosis as it could decrease the oxidative stress in the brain before it can induce more irreversible brain damage.
Abstract: According to the United States Centers for Disease Control and Prevention (CDC), as of July 11, 2016, the reported average incidence of children diagnosed with an autism spectrum disorder (ASD) was 1 in 68 (1.46%) among 8-year-old children born in 2004 and living within the 11 monitoring sites' surveillance areas in the United States of America (USA) in 2012. ASD is a multifaceted neurodevelopmental disorder that is also considered a hidden disability, as, for the most part; there are no apparent morphological differences between children with ASD and typically developing children. ASD is diagnosed based upon a triad of features including impairment in socialization, impairment in language, and repetitive and stereotypic behaviors. The increasing incidence of ASD in the pediatric population and the lack of successful curative therapies make ASD one of the most challenging disorders for medicine. ASD neurobiology is thought to be associated with oxidative stress, as shown by increased levels of reactive oxygen species and increased lipid peroxidation, as well as an increase in other indicators of oxidative stress. Children with ASD diagnosis are considered more vulnerable to oxidative stress because of their imbalance in intracellular and extracellular glutathione levels and decreased glutathione reserve capacity. Several studies have suggested that the redox imbalance and oxidative stress are integral parts of ASD pathophysiology. As such, early assessment and treatment of antioxidant status may result in a better prognosis as it could decrease the oxidative stress in the brain before it can induce more irreversible brain damage. In this review, many aspects of the role of oxidative stress in ASD are discussed, taking into account that the process of oxidative stress may be a target for therapeutic interventions.
TL;DR: This review considers the modern research results in THz diagnosis of malignant and benign neoplasms, along with the topical research and engineering problems, which restrain the THz technology translation to clinics, and discusses existing modalities of THz spectroscopic and imaging systems.
Abstract: Over the past decades, signicant attention has been paid to biomedical applications of terahertz (THz) technology. Nowadays, THz spectroscopy and imaging allow for solving numerous demanding problems in biological, medical, food, plant and pharmaceutical sciences. Among all biomedical applications, a label-free diagnosis of malignant and benign neoplasms represents one of the most attractive branches of THz technology. Despite the attractiveness, the methods of THz diagnosis are still far from medical practice. In this review, we consider the modern research results in THz diagnosis of malignant and benign neoplasms, along with the topical research and engineering problems, which restrain the THz technology translation to clinics. We start from analysis of the common models of THz-wave { tissue interactions and the eects of tissue exposure to THz waves. Then, we discuss existing modalities of THz spectroscopic and imaging systems, which either have been already applied in medical imaging, or hold strong potential. We summarize the earlier-reported and the original results of THz measurements of neoplasms with dierent nosology and localization. We pay attention to the origin of contrast between healthy and pathological tissues in the THz spectra and images and discuss the prospective of THz technology in non-invasive, minimally-invasive and intraoperative diagnosis, as well as in aiding histology. Finally, we review the challenging problems of THz diagnosis, as well as attempts to solve them, which should bring the THz technology much closer to the medical practice. This review allows one to objectively uncover benets and weaknesses of the THz technology in diagnosis of malignant and benign neoplasms.
University of Paris1, University of Milan2, Trinity College, Dublin3, Mashhad University of Medical Sciences4, I.M. Sechenov First Moscow State Medical University5, Loyola University Medical Center6, American Heart Institute7, University of Belgrade8, Catholic University of Cordoba9, University of Zagreb10, Cleveland Clinic11, University of Genoa12, University of Bologna13, National and Kapodistrian University of Athens14, University of Cambridge15, Gazi University16, University of Perugia17, Capital Medical University18, Boston University19, University of Dammam20, Charles University in Prague21, Concord Repatriation General Hospital22, University of Ljubljana23, Academy for Urban School Leadership24, National University of Ireland, Galway25, Medical University of Vienna26, Jan Długosz University27, Medical University of Silesia28, Karolinska Institutet29, The Feinstein Institute for Medical Research30, Comenius University in Bratislava31, Wrocław Medical University32, University of Chicago33, University of Crete34, Catholic University of Leuven35, Mayo Clinic36, Peking Union Medical College37, Peking University38
TL;DR: The VAS-European Independent Foundation in Angiology/Vascular Medicine draws attention to patients with vascular disease (VD) and presents an integral strategy for the management of patients with VD or cardiovascular risk factors (VD-CVR) and COVID-19.
Abstract: COVID-19 is also manifested with hypercoagulability, pulmonary intravascular coagulation, microangiopathy, and venous thromboembolism (VTE) or arterial thrombosis. Predisposing risk factors to severe COVID-19 are male sex, underlying cardiovascular disease, or cardiovascular risk factors including noncontrolled diabetes mellitus or arterial hypertension, obesity, and advanced age. The VAS-European Independent Foundation in Angiology/Vascular Medicine draws attention to patients with vascular disease (VD) and presents an integral strategy for the management of patients with VD or cardiovascular risk factors (VD-CVR) and COVID-19. VAS recommends (1) a COVID-19-oriented primary health care network for patients with VD-CVR for identification of patients with VD-CVR in the community and patients' education for disease symptoms, use of eHealth technology, adherence to the antithrombotic and vascular regulating treatments, and (2) close medical follow-up for efficacious control of VD progression and prompt application of physical and social distancing measures in case of new epidemic waves. For patients with VD-CVR who receive home treatment for COVID-19, VAS recommends assessment for (1) disease worsening risk and prioritized hospitalization of those at high risk and (2) VTE risk assessment and thromboprophylaxis with rivaroxaban, betrixaban, or low-molecular-weight heparin (LMWH) for those at high risk. For hospitalized patients with VD-CVR and COVID-19, VAS recommends (1) routine thromboprophylaxis with weight-adjusted intermediate doses of LMWH (unless contraindication); (2) LMWH as the drug of choice over unfractionated heparin or direct oral anticoagulants for the treatment of VTE or hypercoagulability; (3) careful evaluation of the risk for disease worsening and prompt application of targeted antiviral or convalescence treatments; (4) monitoring of D-dimer for optimization of the antithrombotic treatment; and (5) evaluation of the risk of VTE before hospital discharge using the IMPROVE-D-dimer score and prolonged post-discharge thromboprophylaxis with rivaroxaban, betrixaban, or LMWH.