Institution
Kanazawa Medical University
Education•Kanazawa, Japan•
About: Kanazawa Medical University is a education organization based out in Kanazawa, Japan. It is known for research contribution in the topics: Population & Cancer. The organization has 3103 authors who have published 6322 publications receiving 144592 citations. The organization is also known as: Kanazawa ika daigaku.
Topics: Population, Cancer, Diabetes mellitus, Lung cancer, Blood pressure
Papers published on a yearly basis
Papers
More filters
••
TL;DR: A specific impact of perinatal TCDD on autistic traits in childhood is demonstrated, which is different from the neurotoxicity of total dioxins (PCDDs/Fs).
Abstract: 2,3,7,8-Tetrachlorodibenzo-p-dioxin in breast milk increases autistic traits of 3-year-old children in Vietnam
69 citations
••
TL;DR: The percentage of the double-labeled cell in all the hormone-producing cells is within 10% in all cell-types of the pituitary, including GH cells, suggesting that the self-mitosis of thepituitary cells contributes considerably to their proliferation at a certain period during their ontogenesis.
Abstract: Studies on the proliferation and differentiation of the cells in the rat anterior pituitary were reviewed. The mitotic rate of anterior pituitary is low in the control adult animal, but it increased by stimulation, such as by ablation of the target organ. A high mitotic rate was also reported during ontogenesis of the pituitary. Concomitant with this augmented mitosis, the number of those cells that are double-labeled with the marker of proliferation and the antibody to pituitary hormones increased as well. The percentage of these double-labeled cells in all the proliferating cells is less than 10%, suggesting that about 1/10 of the proliferating cells are involved in producing pituitary cells. This percentage for GH cells is 30-40% at most, suggesting very active production of them. The percentage of the double-labeled cell in all the hormone-producing cells is within 10% in all cell-types of the pituitary, including GH cells. When the proliferation is detected by a more sensitive method, this percentage increased to 20-40%, suggesting that the self-mitosis of the pituitary cells contributes considerably to their proliferation at a certain period during their ontogenesis.
69 citations
••
TL;DR: The pre-operative size of the conventional spinal schwannoma and intralesional resection are the main risk factors for local postoperative recurrence in patients who had surgery.
Abstract: Study Design
Retrospective analysis of 169 adult patients operated for a conventional spinal schwannoma from the AOSpine Multicenter Primary Spinal Tumors Database.
69 citations
••
TL;DR: Cognitive function was impaired, particularly information-processing speed, and decreased cognitive function was correlated with apathy and depression in Japanese patients with MS, suggesting that different therapeutic approaches are needed to improve subjective fatigue and cognition, and thereby quality of life, in patients with multiple sclerosis.
Abstract: Cognitive impairment could affect quality of life for patients with multiple sclerosis (MS), and cognitive function may be correlated with several factors such as depression and fatigue. This study aimed to evaluate cognitive function in Japanese patients with MS and the association between cognitive function and apathy, fatigue, and depression. The Brief Repeatable Battery of Neuropsychological tests (BRB-N) was performed in 184 Japanese patients with MS and 163 healthy controls matched for age, gender, and education. The Apathy Scale (AS), Fatigue Questionnaire (FQ), and Beck Depression Inventory Second Edition (BDI-II) were used to evaluate apathy, fatigue, and depression, respectively. Student’s t-test was used to compare MS patients and healthy controls. Correlations between two factors were assessed using the Pearson correlation test, and multiple regression analysis was used to evaluate how much each factor affected the BRB-N score. In all BRB-N tests, patients with MS scored significantly lower than controls, and the effect size of symbol digit modalities test was the highest among the 9 tests of the BRB-N. Patients with MS had higher AS (p < 0.001), FQ (p < 0.0001), and BDI-II (p < 0.0001) scores than controls. In patients with MS, scores on most of the BRB-N tests correlated with scores on the AS and BDI-II; however, there was little correlation between scores on the BRB-N tests and those on the FQ. Cognitive function was impaired, particularly information-processing speed, and decreased cognitive function was correlated with apathy and depression in Japanese patients with MS. Despite the association between cognitive variables and depression/apathy, cognitive function was impaired beyond the effect of depression and apathy. However, subjective fatigue is not related with cognitive impairment. Taken together, this suggests that different therapeutic approaches are needed to improve subjective fatigue and cognition, and thereby quality of life, in patients with MS.
69 citations
••
69 citations
Authors
Showing all 3113 results
Name | H-index | Papers | Citations |
---|---|---|---|
Michael Marmot | 193 | 1147 | 170338 |
Tadamitsu Kishimoto | 181 | 1067 | 130860 |
Masayuki Yamamoto | 171 | 1576 | 123028 |
Zena Werb | 168 | 473 | 122629 |
Toshio Hirano | 120 | 401 | 55721 |
John T. Isaacs | 88 | 356 | 28217 |
Hiroshi Sasaki | 76 | 644 | 24222 |
Takuji Tanaka | 75 | 490 | 20946 |
Hiroshi Shimizu | 71 | 1368 | 26668 |
Daisuke Koya | 67 | 294 | 18746 |
Masashi Tanaka | 65 | 396 | 17110 |
Masashi Akiyama | 65 | 685 | 16404 |
Masayoshi Takeuchi | 64 | 279 | 13651 |
Takashi Yoshida | 63 | 328 | 13680 |
Tsutomu Hatano | 61 | 299 | 13668 |