Kanazawa Medical University

About: Kanazawa Medical University is a education organization based out in Kanazawa, Japan. It is known for research contribution in the topics: Population & Cancer. The organization has 3103 authors who have published 6322 publications receiving 144592 citations. The organization is also known as: Kanazawa ika daigaku.

Glyceraldehyde caused Alzheimer's disease-like alterations in diagnostic marker levels in SH-SY5Y human neuroblastoma cells.

Abstract: Clinical evidence has implicated diabetes mellitus as one of the risk factors for the development and progression of Alzheimer's disease (AD). However, the neurotoxic pathway activated due to abnormalities in glucose metabolism has not yet been identified in AD. In order to investigate the relationship between impaired cerebral glucose metabolism and the pathophysiology of AD, SH-SY5Y human neuroblastoma cells were exposed to glyceraldehyde (GA), an inhibitor of glycolysis. GA induced the production of GA-derived advanced glycation end-products (GA-AGEs) and cell apoptosis, glycolytic inhibition, decreases in the medium concentrations of diagnostic markers of AD, such as amyloid β 1-42 (Aβ42), and increases in tau phosphorylation. These results suggest that the production of GA-AGEs and/or inhibition of glycolysis induce AD-like alterations, and this model may be useful for examining the pathophysiology of AD.

Guidelines for treatment of hypertension in the elderly--2002 revised version.

Abstract: From the Research Group for “Long-Term Prognosis of Hypertension in the Elderly,” Comprehensive Research Projects on Aging and Health, the Ministry of Health, Labor and Welfare of Japan: *1Osaka University Graduate School of Medicine, *2Ehime University School of Medicine, *3Kanazawa Medical University, *4Dokkyo University School of Medicine, *5University of the Ryukyus School of Medicine, *6Sapporo Medical University, *7Jichi Medical School, *8Kyushu University, Graduate School of Medical Sciences, *9University of Tokyo Graduate School of Medicine, * 10International University of Health and Welfare, * 11Saitama Medical University, and * 12Tohoku University Graduate School of Pharmaceutical Science, Japan. Address for Reprints: Toshio Ogihara, M.D., Ph.D., Department of Geriatric Medicine, Osaka University Graduate School of Medicine, 2–2 Yamadaoka, Suita, Osaka 565–0871, Japan. E-mail: ogihara@geriat.med.osaka-u.ac.jp Received and Accepted September 6, 2002. novo” types. The former generally develops in middle age as essential hypertension, and becomes systolic hypertension as the diastolic blood pressure is reduced due to the aging process, while the latter develops in old age due to reduced vascular compliance in the large arteries. In addition, there are some cases with secondary hypertension due to identifiable causes such as renovascular hypertension. In the elderly, it has been reported that systolic blood pressure is more strongly related with cardiovascular complications—especially stroke, ischemic heart disease, heart failure, end-stage renal disease, and all-cause mortality—than is diastolic blood pressure (3). Furthermore, it has been demonstrated that increased pulse pressure (the difference between systolic blood pressure and diastolic blood pressure) is correlated with an increased risk of such complications (4). The pathophysiology of hypertension in the elderly is characterized by increased total peripheral vascular resistance, decreased compliance of large and middle arteries, a tendency toward decrease in cardiac output and circulating blood volume, increased lability of blood pressure due to age-related decrease in baroreceptor function, decreased blood flow, and dysfunction of autoregulation in important target-organs such as the brain, heart, and kidney. Therefore, Introduction

Delayed Postanoxic Encephalopathy After Strangulation Serial Neuroradiological and Neurochemical Studies

Abstract: A 13-year-old boy was the victim of attempted strangulation. His condition had returned to normal by the sixth day after the assault; however, from the seventh day, choreoathetosis, dystonia, and marked pseudobulbar paralysis developed in the boy. The computed tomographic scans and T2-weighted magnetic resonance images that were obtained at this time revealed low-density and high-signal intensities in the region of the bilateral putamen and caudate nucleus. These symptoms and the changes in his computed tomographic scans and magnetic resonance images subsided gradually during a 2-month period. Sequential analysis of the cerebrospinal fluid for gamma-aminobutyric acid and dopamine concentrations during his illness revealed reciprocal changes with normal recovery. Because of the delayed onset of neurological changes and the cerebrospinal fluid showing reversible symptoms, the delayed encephalopathy after strangulation had been related to the biochemical alterations that followed anoxia in the vulnerable basal ganglia.

Relationship of alcohol consumption to 7-year blood pressure change in Japanese men.

Abstract: OBJECTIVE To determine the association of alcohol consumption with years-long blood pressure (BP) change, as well as baseline BP, adjusted for potential confounders. DESIGN A prospective cohort study. SETTING A metal-products factory in Toyama, Japan. PARTICIPANTS A total of 3900 men aged 20-59 years. MAIN OUTCOME MEASURES BP was measured annually for 7 years after the baseline examination. The generalized estimating equation method was used to analyze the relationship of alcohol consumption to baseline BP and average annual BP change, adjusting for age, yearly weight, work-related factors, and lifestyle factors, including the frequency of intake of 22 food groups. RESULTS The baseline systolic BP after multivariate adjustment was 3.9 and 5.0 mmHg higher in drinkers consuming 200-299 and > or = 300 g alcohol/week, respectively, than in non-drinkers (P or = 300 g/week than in non-drinkers after adjustment for age and weight change (P or = 300 g/week showed a 0.33 mmHg greater annual increase in systolic BP than non-drinkers (P = 0.022). Baseline diastolic BP was significantly associated with alcohol consumption, but annual BP change was not. CONCLUSIONS An alcohol intake > or = 300 g/week was associated with significantly greater annual BP increase, and baseline BP was significantly higher in drinkers consuming > or = 200 g/week. It is necessary to limit alcohol intake to less than 200 g/week to prevent hypertension.