Kharazmi University

About: Kharazmi University is a education organization based out in Tehran, Iran. It is known for research contribution in the topics: Membrane & Supply chain. The organization has 3395 authors who have published 5321 publications receiving 45645 citations. The organization is also known as: Tarbiat Moallem University of Tehran & Teacher Training University.

Biological Evaluation of a New Synthesized Pt(II) Complex by Cytotoxic and Spectroscopic Studies

Abstract: In this study, the interaction of β-casein (β-CN) with a new synthesized Pt(II) complex (bipyridin morpholin dithiocarbamate Pt(II) nitrate), as an anticancer compound, was studied. This study was carried by fluorescence and circular dichroism (CD) measurements at 25 and 37° C. Also, cytotoxicity and apoptotic activity of the complex were studied against cancer model cell line of K562 using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Fluorescence data revealed that the intrinsic fluorescence of β-CN was quenched by the addition of Pt(II) complex through dynamic quenching mechanism. The CD spectra indicated that the binding of Pt(II) complex to β-CN causes a slight conformational change in the secondary structure of protein. Also, MTT assay represented growth inhibitory effect of the complex toward the cancer cell line. From above results, it can be concluded that β-CN can bind to the Pt complex and transfer this new anticancer drug. It may be suggested that the antitumor activity of this complex against K562 cell reveals typical morphology features of apoptotic death.

Optimization of multi-product economic production quantity model with partial backordering and physical constraints

Abstract: The average RPE of the solutions obtained for large size problems.Display Omitted A multi-product EPQ model with several technical and physical constraints is developed.Shortages are allowed and partially backordered with fixed and linear costs.SQP, SFS, SA, and WCA are utilized for solution.Ninety numerical examples in small, medium, and large sizes are solved to evaluate the performances.The results show the better performance of WCA. A multi-product economic production quantity model with several real-world technical and physical constraints is developed in this paper. The cost function includes ordering, holding, backordering, lost sale, and the cost caused by unused space in the warehouse. The goal is to minimize the total inventory cost, where shortages are allowed and partially backordered with fixed and linear costs. The aim is to determine the length of the inventory cycle, the length of positive inventory period, and the backordering rates of the products during the shortage period in order to minimize the total inventory costs while satisfying all constraints. Due to complexity and non-linearity of the proposed model, sequential quadratic programming (SQP), stochastic fractal search (SFS), simulated annealing (SA), and water cycle algorithm (WCA) are utilized for solution. Ninety numerical examples in small, medium, and large sizes are solved to evaluate the efficiency of the solution methods. The performances of the solution methods are compared statistically. Besides, sensitivity analysis is performed to determine the effect of change in the main parameters of the problem on the objective function value and decision variables.

Plagiarism Among Iranian Graduate Students of Language Studies: Perspectives and Causes

Abstract: In this study, we investigated the ability of Iranian students of applied linguistics to discern plagiarism in writing, their perceptions of its ethical aspects, their characterizations of plagiarists, and their perspectives on why they may commit plagiarism. In so doing, a slightly revised version of Deckert’s 1993 questionnaire, collecting both quantitative and qualitative data, was electronically distributed among 156 graduate students of applied linguistics. The results of the quantitative data analysis revealed some understanding of the concept but an inconsistent performance in recognizing plagiarism. Regarding issues of ethics and fairness, they were concerned with their own needs along with the original writer’s rights more than with rights of their classmates, colleagues, or teachers. They regarded unfamiliarity with the concept and nature of plagiarism as the main reason for committing it. The analysis of the qualitative data yielded the following reasons for students’ plagiarism: students’ unfa...