Korea Institute of Science and Technology Information

About: Korea Institute of Science and Technology Information is a facility organization based out in Daejeon, South Korea. It is known for research contribution in the topics: Gravitational wave & LIGO. The organization has 1152 authors who have published 2319 publications receiving 93849 citations. The organization is also known as: Korea Institute of Science and Technology Information & KISTI.

Prospects for beyond the Standard Model physics searches at the Deep Underground Neutrino Experiment: DUNE Collaboration.

Abstract: The Deep Underground Neutrino Experiment (DUNE) will be a powerful tool for a variety of physics topics. The high-intensity proton beams provide a large neutrino flux, sampled by a near detector system consisting of a combination of capable precision detectors, and by the massive far detector system located deep underground. This configuration sets up DUNE as a machine for discovery, as it enables opportunities not only to perform precision neutrino measurements that may uncover deviations from the present three-flavor mixing paradigm, but also to discover new particles and unveil new interactions and symmetries beyond those predicted in the Standard Model (SM). Of the many potential beyond the Standard Model (BSM) topics DUNE will probe, this paper presents a selection of studies quantifying DUNE’s sensitivities to sterile neutrino mixing, heavy neutral leptons, non-standard interactions, CPT symmetry violation, Lorentz invariance violation, neutrino trident production, dark matter from both beam induced and cosmogenic sources, baryon number violation, and other new physics topics that complement those at high-energy colliders and significantly extend the present reach.

Brain somatic mutations observed in Alzheimer's disease associated with aging and dysregulation of tau phosphorylation

Abstract: The role of brain somatic mutations in Alzheimer’s disease (AD) is not well understood. Here, we perform deep whole-exome sequencing (average read depth 584×) in 111 postmortem hippocampal formation and matched blood samples from 52 patients with AD and 11 individuals not affected by AD. The number of somatic single nucleotide variations (SNVs) in AD brain specimens increases significantly with aging, and the rate of mutation accumulation in the brain is 4.8-fold slower than that in AD blood. The putatively pathogenic brain somatic mutations identified in 26.9% (14 of 52) of AD individuals are enriched in PI3K-AKT, MAPK, and AMPK pathway genes known to contribute to hyperphosphorylation of tau. We show that a pathogenic brain somatic mutation in PIN1 leads to a loss-of-function mutation. In vitro mimicking of haploinsufficiency of PIN1 aberrantly increases tau phosphorylation and aggregation. This study provides new insights into the genetic architecture underlying the pathogenesis of AD. The role of brain somatic mutations in neurodegenerative diseases such as Alzheimer’s disease (AD) is not well understood. Here the authors carry out high-depth exome sequencing ~500× on brain tissue from patients with AD and controls, and identify mutations in a number of genes that are known to contribute to phosphorylation and aggregation of tau, including PIN1.

Model Comparison from LIGO-Virgo Data on GW170817's Binary Components and Consequences for the Merger Remnant

Abstract: GW170817 is the very first observation of gravitational waves originating from the coalescence of two compact objects in the mass range of neutron stars, accompanied by electromagnetic counterparts, and offers an opportunity to directly probe the internal structure of neutron stars. We perform Bayesian model selection on a wide range of theoretical predictions for the neutron star equation of state. For the binary neutron star hypothesis, we find that we cannot rule out the majority of theoretical models considered. In addition, the gravitational-wave data alone does not rule out the possibility that one or both objects were low-mass black holes. We discuss the possible outcomes in the case of a binary neutron star merger, finding that all scenarios from prompt collapse to long-lived or even stable remnants are possible. For long-lived remnants, we place an upper limit of 1.9 kHz on the rotation rate. If a black hole was formed any time after merger and the coalescing stars were slowly rotating, then the maximum baryonic mass of non-rotating neutron stars is at most 3.05M⊙, and three equations of state considered here can be ruled out. We obtain a tighter limit of 2.67M⊙ for the case that the merger results in a hypermassive neutron star.

Search for B→h(*)νν̄ with the full Belle Υ(4S) data sample

Abstract: We report a search for the rare decays B -> h(*) nu nubar, where h(*) stands for K+, Ks0, K*+, K*0, pi+, pi0, rho+, rho0 and phi. The results are obtained from a 711 fb-1 data sample that contains 772 million BB pairs collected at the Y(4S) resonance with the Belle detector at the KEKB e+e- collider. We search for signal candidates by fully reconstructing a hadronic decay of the accompanying B meson and requiring a single h(*) meson left on the signal side. No significant signal is observed and we set upper limits on the branching fractions at 90% confidence level. The measurements of B+ -> K*+ nu nubar, B+ -> pi+ nu nubar, B0 -> pi0 nu nubar and B0 -> rho^0 nu nubar provide the world's currently most restrictive limits.