Institution
New Generation University College
Education•Addis Ababa, Ethiopia•
About: New Generation University College is a education organization based out in Addis Ababa, Ethiopia. It is known for research contribution in the topics: Population & Cancer. The organization has 17440 authors who have published 28460 publications receiving 667288 citations. The organization is also known as: National University College.
Topics: Population, Cancer, Breast cancer, Medicine, Transplantation
Papers published on a yearly basis
Papers
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TL;DR: Simultaneous left ventricular pressure measurements and Doppler examinations were performed in 200 consecutive patients to validate the clinical usefulness of E/E' ratio and showed that quantitative estimation ofleft ventricular pre-A pressure could be suggested by the simplified equation of pre- A pressure = E/ E' + 4 with reasonable accuracy.
Abstract: The ratio of early mitral inflow to early mitral annular velocity (E/E') was suggested as a useful index in the estimation of left ventricular filling pressure. This study was performed to validate the clinical usefulness of E/E' ratio in a large number of patients. Simultaneous left ventricular pressure measurements and Doppler examinations were performed in 200 consecutive patients at the cardiac catheterization laboratory. The E/E' ratio correlated well with pre-A-wave pressure (r = 0.74, P or = 50%: r = 0.74, P or = 9 best discriminated elevated (<12 mm Hg) from normal left ventricular pre-A pressure with a sensitivity of 81% and a specificity of 80%. Our study results also showed that quantitative estimation of left ventricular pre-A pressure could be suggested by the simplified equation of pre-A pressure = E/E' + 4 with reasonable accuracy.
126 citations
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TL;DR: The incidence of active tuberculosis is increased in rheumatic patients on moderate-to-high dose steroid treatment and its risk factors are the cumulative and mean daily steroid doses during the follow-up period and during the first year of steroid treatment, and a history of steroid pulse therapy.
Abstract: Objective To investigate the incidence and risk factors of Mycobacterium tuberculosis infection in longterm corticosteroid treated rheumatic disease patients. Methods We assessed retrospectively the incidence of active tuberculosis and its risk factors in 269 rheumatic disease patients treated with moderate to high doses of corticosteroid for an evaluation period representing 1,035 corticosteroid years of therapy. Results The mean daily dose of steroid was 18.7 mg prednisolone and the mean daily dose during the first year of treatment was 20.4 mg prednisolone. 21 of these patients developed active tuberculosis resulting in an incidence rate of 20/1,000 patient-years. Cumulative and mean daily steroid doses during the follow-up period and during the first year of treatment, and a history of steroid pulse therapy were significantly correlated with the development of tuberculosis. A past history of tuberculosis, initial chest P-A abnormality, the starting dose of steroid, a history of more than 30 mg/day of prednisolone for more than one month, and a history of cytotoxic therapy were not related to the development of tuberculosis. Conclusion The incidence of active tuberculosis is increased in rheumatic patients on moderate-to-high dose steroid treatment. Its risk factors are the cumulative and mean daily steroid doses during the follow-up period and during the first year of steroid treatment, and a history of steroid pulse therapy.
126 citations
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TL;DR: It is shown that E2-EPF ubiquitin carrier protein (UCP) associates with and targets pVHL for ubiqu itin-mediated proteolysis in cells, thereby stabilizing HIF-1α and may be a new molecular target for therapeutic intervention in human cancers.
Abstract: The von Hippel-Lindau tumor suppressor, pVHL, forms part of an E3 ubiquitin ligase complex that targets specific substrates for degradation, including hypoxia-inducible factor-1alpha (HIF-1alpha), which is involved in tumor progression and angiogenesis. It remains unclear, however, how pVHL is destabilized. Here we show that E2-EPF ubiquitin carrier protein (UCP) associates with and targets pVHL for ubiquitin-mediated proteolysis in cells, thereby stabilizing HIF-1alpha. UCP is detected coincidently with HIF-1alpha in human primary liver, colon and breast tumors, and metastatic cholangiocarcinoma and colon cancer cells. UCP level correlates inversely with pVHL level in most tumor cell lines. In vitro and in vivo, forced expression of UCP boosts tumor-cell proliferation, invasion and metastasis through effects on the pVHL-HIF pathway. Our results suggest that UCP helps stabilize HIF-1alpha and may be a new molecular target for therapeutic intervention in human cancers.
126 citations
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TL;DR: The results suggest that ROS repress the hepcidin gene by preventing C/EBPalpha and STAT-3 binding to hePCidin promoter during hypoxia.
126 citations
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TL;DR: Preoperative MTV is an independent prognostic factor for DFS in patients with cervical cancer treated by radical surgery, and is found to be correlated with lymph node (LN) metastasis, parametrium (PM) involvement, FIGO stage, and SUV(max).
126 citations
Authors
Showing all 17571 results
Name | H-index | Papers | Citations |
---|---|---|---|
Gregory Y.H. Lip | 169 | 3159 | 171742 |
Roberto Romero | 151 | 1516 | 108321 |
Paul D.P. Pharoah | 130 | 794 | 71338 |
Hyunyong Kim | 114 | 1433 | 65154 |
Jung-Hyun Kim | 113 | 1195 | 56181 |
Bertram L. Kasiske | 110 | 476 | 52219 |
Ki-Hyun Kim | 99 | 1911 | 52157 |
Nosratola D. Vaziri | 98 | 708 | 34586 |
Tetsuo Nagano | 96 | 490 | 34267 |
Yung-Jue Bang | 94 | 664 | 46313 |
Young-Ho Khang | 94 | 262 | 119219 |
Jae Y. Ro | 93 | 747 | 34462 |
Neal D. Ryan | 91 | 316 | 35163 |
John Kim | 90 | 406 | 41986 |
Dong Wan Kim | 89 | 833 | 49632 |