Institution
New Generation University College
Education•Addis Ababa, Ethiopia•
About: New Generation University College is a education organization based out in Addis Ababa, Ethiopia. It is known for research contribution in the topics: Population & Cancer. The organization has 17440 authors who have published 28460 publications receiving 667288 citations. The organization is also known as: National University College.
Topics: Population, Cancer, Breast cancer, Medicine, Transplantation
Papers published on a yearly basis
Papers
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TL;DR: Results indicate that heat shock-induced ROS is promoted via NADPH oxid enzyme, xanthine oxidase, and mitochondria, which may play an important role in the heatshock-induced activation of MAPKs, which can induce MMP-1 and-9 expressions.
133 citations
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TL;DR: It is found that PI3Kγ has a crucial and specific role in NMDA receptor (NMDAR)-mediated synaptic plasticity at mouse Schaffer collateral–commissural synapses and the impairment of NMDAR LTD by PI3kγ blockade was specifically correlated with deficits in behavioral flexibility.
Abstract: Phosphatidylinositol 3-kinase (PI3K) has been implicated in synaptic plasticity and other neural functions in the brain. However, the role of individual PI3K isoforms in the brain is unclear. We investigated the role of PI3Kγ in hippocampal-dependent synaptic plasticity and cognitive functions. We found that PI3Kγ has a crucial and specific role in NMDA receptor (NMDAR)-mediated synaptic plasticity at mouse Schaffer collateral-commissural synapses. Both genetic deletion and pharmacological inhibition of PI3Kγ disrupted NMDAR long-term depression (LTD) while leaving other forms of synaptic plasticity intact. Accompanying this physiological deficit, the impairment of NMDAR LTD by PI3Kγ blockade was specifically correlated with deficits in behavioral flexibility. These findings suggest that a specific PI3K isoform, PI3Kγ, is critical for NMDAR LTD and some forms of cognitive function. Thus, individual isoforms of PI3Ks may have distinct roles in different types of synaptic plasticity and may therefore influence various kinds of behavior.
133 citations
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TL;DR: The safety and efficacy of pembrolizumab in patients with advanced gastric cancer in KEYNOTE-012 is assessed and primary efficacy end point is ORR assessed per RECIST v1.1 by independent central review.
Abstract: 3 Background: Tumors use the PD-1 pathway to evade immune surveillance. Pembrolizumab, an anti-PD-1 monoclonal antibody, has shown antitumor activity in advanced cancers. We assessed the safety and efficacy of pembrolizumab in patients with advanced gastric cancer in KEYNOTE-012 (Clinicaltrials.gov identifier NCT01848834). Methods: Archival tumor samples from patients from Asia-Pacific (AP) and rest of the world (ROW) with recurrent or metastatic adenocarcinoma of the stomach or gastroesophageal junction were screened for PD-L1 expression using a prototype IHC assay with the 22C3 antibody. Only patients with distinctive stromal or ≥1% tumor nest cell PD-L1 staining were eligible. Patients received pembrolizumab 10 mg/kg every 2 weeks for up to 24 months or until complete response, progression, or unacceptable toxicity. Imaging was performed every 8 weeks. Primary efficacy end point is ORR assessed per RECIST v1.1 by independent central review. Secondary end points include duration of response, PFS, and OS...
133 citations
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TL;DR: During spinal block, there seems to be a safety margin of 2–4 vertebral bodies and intervertebral spaces between the conus medullaris and Tuffier's line, which is consistent regardless of sex or presence of transitional vertebra.
Abstract: BackgroundThe purpose of this study was to analyze the position of the conus medullaris and Tuffier's line in the same patient population, to correlate this position with age and sex, and to determine an objective guide for the selection of a safe intervertebral space during spinal block.MethodsMagn
133 citations
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Columbia University Medical Center1, University of Sannio2, Columbia University3, University of Texas MD Anderson Cancer Center4, University of Montpellier5, University of Paris6, Medical University of South Carolina7, University of Milan8, Claude Bernard University Lyon 19, Carlo Besta Neurological Institute10, Boston Children's Hospital11, Samsung Medical Center12, Sungkyunkwan University13, Hospital Sant Joan de Déu Barcelona14, French Institute of Health and Medical Research15, Paris Descartes University16, University of Birmingham17, Memorial Sloan Kettering Cancer Center18, University Hospital Heidelberg19, German Cancer Research Center20, New Generation University College21
TL;DR: It is found that the predisposing germline mutation of the NF1 gene was frequently converted to homozygosity and the somatic mutational load of NF1-glioma was influenced by age and grade, which defined a distinct landscape that recapitulates a subset of sporadic tumors.
Abstract: Neurofibromatosis type 1 (NF1) is a common tumor predisposition syndrome in which glioma is one of the prevalent tumors. Gliomagenesis in NF1 results in a heterogeneous spectrum of low- to high-grade neoplasms occurring during the entire lifespan of patients. The pattern of genetic and epigenetic alterations of glioma that develops in NF1 patients and the similarities with sporadic glioma remain unknown. Here, we present the molecular landscape of low- and high-grade gliomas in patients affected by NF1 (NF1-glioma). We found that the predisposing germline mutation of the NF1 gene was frequently converted to homozygosity and the somatic mutational load of NF1-glioma was influenced by age and grade. High-grade tumors harbored genetic alterations of TP53 and CDKN2A, frequent mutations of ATRX associated with Alternative Lengthening of Telomere, and were enriched in genetic alterations of transcription/chromatin regulation and PI3 kinase pathways. Low-grade tumors exhibited fewer mutations that were over-represented in genes of the MAP kinase pathway. Approximately 50% of low-grade NF1-gliomas displayed an immune signature, T lymphocyte infiltrates, and increased neo-antigen load. DNA methylation assigned NF1-glioma to LGm6, a poorly defined Isocitrate Dehydrogenase 1 wild-type subgroup enriched with ATRX mutations. Thus, the profiling of NF1-glioma defined a distinct landscape that recapitulates a subset of sporadic tumors. An integrated analysis of glioma samples from patients with neurofibromatosis 1 annotates their mutational, epigenetic, transcriptional, and immunological features and uncovers similitudes with a subset of sporadic gliomas.
133 citations
Authors
Showing all 17571 results
Name | H-index | Papers | Citations |
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Gregory Y.H. Lip | 169 | 3159 | 171742 |
Roberto Romero | 151 | 1516 | 108321 |
Paul D.P. Pharoah | 130 | 794 | 71338 |
Hyunyong Kim | 114 | 1433 | 65154 |
Jung-Hyun Kim | 113 | 1195 | 56181 |
Bertram L. Kasiske | 110 | 476 | 52219 |
Ki-Hyun Kim | 99 | 1911 | 52157 |
Nosratola D. Vaziri | 98 | 708 | 34586 |
Tetsuo Nagano | 96 | 490 | 34267 |
Yung-Jue Bang | 94 | 664 | 46313 |
Young-Ho Khang | 94 | 262 | 119219 |
Jae Y. Ro | 93 | 747 | 34462 |
Neal D. Ryan | 91 | 316 | 35163 |
John Kim | 90 | 406 | 41986 |
Dong Wan Kim | 89 | 833 | 49632 |