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TL;DR: While oxidative stress has been implicated in pathology of various neurodegenerative disorders, the present study pinpoints the direct link between LPO and Aβ production in plasma of AD patients, thereby enhancing oxidative stress and LPO.
Abstract: Many factors are involved in Alzheimer’s disease (AD) pathology including tau phosphorylation, amyloid β protein (Aβ) accumulation, lipid dysregulation, oxidative stress and inflammation. The markers of these pathological processes in cerebral spinal fluid CSF are used currently for AD diagnosis. However peripheral biomarkers are the need of the hour for large population screening for AD. The main objective of the present study is to evaluate the peripheral levels of redox markers, lipid peroxidation indicators and pathological markers in AD patients. Blood was collected from AD patients (n=45), controls (n=45) and analyzed for pathological markers of AD including Aβ42 and tau, lipid peroxidation and redox indicators. Plasma Aβ42 was significantly (P<0.001) elevated while total tau was decreased in AD compared to controls. Hydroxynonenal (HNE) and Malondialdehyde (MDA), were higher (P<0.001) in AD patients pointing the enhanced lipid peroxidation in AD pathology. Receiver operating characteristic curve (ROC) analysis indicated that HNE is a better indicator of lipid peroxidation compared to MDA. Plasma glutathione (GSH) level was significantly (P<0.001) low while oxidized glutathione (GSSG) level was higher (P<0.001) in AD patients with corresponding decrease in GSH/GSSG ratio (P<0.001). ROC analysis indicated that GSH/GSSG ratio can be used as reliable indicator for redox imbalance in AD with a cutoff value of <8.73 (Sensitivity 91.1%, Specificity 97.8%). Correlation analysis revealed a positive correlation for both HNE and MDA with Aβ42 and a negative correlation with total tau. Negative correlation was observed between GSH/GSSG ratio and lipid peroxidation markers. While oxidative stress has been implicated in pathology of various neurodegenerative disorders, the present study pinpoints the direct link between lipid peroxidation and Aβ production in plasma of AD patients. Normally at low amyloid concentration in body fluids, this peptide shown to function as a strong metal chelating antioxidant. However when the Aβ production enhanced as in AD, through gain of functional transformation, Aβ evolves into prooxidant thereby enhancing oxidative stress and LPO. Altered redox status with enhanced lipid peroxidation observed in AD blood could contribute to the oxidation and S –Glutathionylation proteins which has to be addressed in future studies.
38 citations
TL;DR: In this article, the nucleation and growth of chemical conversion coating on Mg-4Zn alloy prepared by immersion in saturated NaHCO3 at ambient temperature and its corrosion behaviour in simulated body fluid (SBF) is investigated.
38 citations
TL;DR: In this article, the photocatalytic property of a novel AgCl loaded carbon nitride composite was reported by a simple precipitation route, where the brown colored g-C3N5 was synthesized by a nano-hard templating method using 3-amino-1,2,4-triazole precursor.
38 citations
TL;DR: In this article, noise pollution is taken into major concea-tral factors such as pollution, global warming, and unhealthy human practices, and a review paper is presented, where the authors take noise pollution into consideration.
Abstract: Nowadays, the world becomes more contaminated due to various factors such as pollution, global warming and unhealthy human practices. In this review paper, noise pollution is taken into major conce...
38 citations
TL;DR: In this paper, a software to compute the parameters using these empirical equations was developed, and four new solid models of impeller and casing were designed by inputting these parameters in a Pro/E software package, and subjected to analysis using GAMBIT and FLUENT software packages.
Abstract: The pump industry is the one which is yet to exhibit agile characteristics by evolving new models quickly in accordance with the dynamic demands of the customers. The researchers have not yet explored the potential of infusing agile characteristics in the pump industry. In order to initiate exploration in this direction, the research reported in this paper was carried out. To begin with, the empirical equations used for designing the pump components namely impeller and casing were referred. Subsequently, a software to compute the parameters using these empirical equations was developed. By inputting these parameters in a Pro/E software package, four new solid models of impeller and casing were designed. These newly designed models were subjected to analysis using GAMBIT and FLUENT software packages. Subsequently, rapid prototyping technology was adopted to develop the prototype of one of those models of impeller. In order to obtain the industry view of this research, four practicing experts were approached with a questionnaire to gather their reactions. The results of their reactions indicated that this research could be practically applied to achieve agile product development through the interfacing of computer-aided design (CAD) and rapid prototyping technologies.
38 citations
Authors
Showing all 3174 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Mohan K. Balasubramanian | 47 | 130 | 6238 |
| Dong-Sheng Jeng | 45 | 398 | 7548 |
| Bruce H. Thomas | 43 | 274 | 6662 |
| S. Vinodh | 41 | 239 | 5610 |
| S. G. Ponnambalam | 33 | 186 | 3573 |
| V.S. Raja | 29 | 119 | 2745 |
| Bheemappa Suresha | 26 | 148 | 2213 |
| S. Basavarajappa | 26 | 92 | 2672 |
| Periasamy Viswanathamurthi | 25 | 92 | 2443 |
| N. Jawahar | 25 | 69 | 1812 |
| Ram Ramesh | 24 | 129 | 1966 |
| Sundaramoorthy Rajasekaran | 24 | 52 | 1659 |
| S.R. Devadasan | 23 | 30 | 1148 |
| Sam Anand | 23 | 86 | 1698 |
| R. Balasundaraprabhu | 23 | 59 | 1375 |