Saxion University of Applied Sciences

About: Saxion University of Applied Sciences is a education organization based out in Enschede, Netherlands. It is known for research contribution in the topics: Health care & Context (language use). The organization has 390 authors who have published 653 publications receiving 8859 citations. The organization is also known as: Saxion University of Applied Sciences.

Development of Silicone Hydrogel Antimicrobial Contact Lenses with Mel4 Peptide Coating

Abstract: Significance This study investigated the development of an antimicrobial coating on silicone hydrogel contact lenses that may have the capacity to reduce contact lens-related infection and inflammatory events. Purpose The purpose of this study was to develop an effective antimicrobial coating for silicone hydrogel contact lenses by attachment of Mel4 peptide. Methods Lotrafilcon A, comfilcon A, somofilcon A, senofilcon A, and lotrafilcon B silicone hydrogel contact lenses were plasma coated with acrylic acid followed by Mel4 antimicrobial peptide immobilization by covalent coupling. Peptide immobilization was quantified by x-ray electron spectroscopy. Contact lens diameter, base curve, center thickness, and lens surface wettability were measured by captive-bubble contact-angle technique. Antimicrobial activity of the lenses was determined against Pseudomonas aeruginosa and Staphylococcus aureus by viable plate count and also after soaking with artificial tears solution for 1 day. In vivo safety and biocompatibility were determined in an animal model for 1 week. Results Mel4 peptide-coated silicone hydrogel contact lenses were associated with high antimicrobial inhibition (>2 log), except for lotrafilcon B and senofilcon A. Lotrafilcon B did not exhibit any activity, whereas senofilcon A showed 1.4- and 0.7-log inhibition against P. aeruginosa and S. aureus, respectively. X-ray electron spectroscopy revealed significant increases in the lens surface-bound amide nitrogen in all contact lenses except for lotrafilcon B. All contact lens parameters remained unchanged except for the base curve and center thickness for senofilcon A. Mel4 immobilization was associated with a decrease in contact angle. Mel4-coated contact lens wear was not associated with any signs or symptoms of ocular irritation in a rabbit model study. Reduced antimicrobial activity was observed with all the lenses after soaking with artificial tears solution or rabbit wear. Conclusions Mel4 antimicrobial coating may be an effective option for development of antimicrobial silicone hydrogel contact lenses.

Everyday life consequences of substance use in adult patients with a substance use disorder (SUD) and co-occurring attention deficit/hyperactivity disorder (ADHD) or autism spectrum disorder (ASD): a patient’s perspective

Abstract: Although the prevalence of substance use disorder (SUD) with co-occurring attention deficit/hyperactivity disorder (ADHD) or autism spectrum disorder (ASD) is relatively high in adult patients, there is hardly any knowledge about these dual diagnoses. A recent study reported met- and unmet needs for several life domains regarding these patient groups. To improve treatment, it is necessary to identify the everyday life consequences of SUD and co-occurring ADHD or ASD in adult patients. Qualitative study using in-depth interviews. 11 SUD + ADHD and 12 SUD + ASD patients participated in the study. The interview transcripts were coded and analysed according to the seven steps for descriptive phenomenology by Colaizzi. Both patients with ADHD and patients with ASD can get caught in a jumble of thoughts and emotions which can often lead to agitation and impulsivity in the case of ADHD or passivity and melancholia in the case of ASD with co-occurring SUD in both cases. Initially substance use ameliorates the symptoms and related problems, but both patient groups can later experience even greater problems: difficulties with the structuring of daily life due to a lack of planning (SUD + ADHD) or due to a lack of initiative (SUD + ASD). Both groups indicate that structure helps them function better. They also recognize that substance use disorganizes their lives and that an absence of structure contributes to substance use in what becomes a vicious circle which needs to be broken for effective treatment and care. This study provides insight into the daily life consequences of SUD with a co-occurring ADHD or ASD. Substance use is reported to solve some ADHD- or ASD-related problems in the short run but have negative consequences in the long run (i.e., contribute to already impaired cognitive functioning). Insight is provided into what clinicians can do to break this vicious circle and thus help ADHD patients to refrain from action and ASD patients to take action.

Listening to the ones who care: exploring the perceptions of informal caregivers towards ambient assisted living applications

Abstract: Ambient assisted living (AAL) technologies have received increased attention from government, industry and research. Informal caregivers will be directly affected by the use of these technologies and are likely to be key influencers in the adoption decision of older adults. However, so far the informal caregivers’ perceptions, concerns and needs have been mostly overlooked in AAL research. To address these shortcomings, two studies were conducted. Study I consisted of 20 in-depth interviews with informal caregivers to investigate their perception of various AAL applications. In Study II these findings were validated with regard to our own prototype application called SONOPA. The second study included couples of informal caregivers and care receivers to compare both user groups. Although informal caregivers had a more positive attitude than care receivers and appreciated the opportunities of AAL technologies (e.g., increased safety, peace of mind); they also had several concern such as invading the care receiver’s privacy, the lack of human touch, and the care receiver’s technology experience. To address these concerns, informal caregivers should be more involved when developing AAL applications.

Effective self-regulatory processes in higher education: research findings and future directions. A systematic review

Abstract: Although self-regulated learning (SRL) is assumed to benefit learning outcomes, gaps in the literature make it difficult to describe what constitutes effective SRL in higher education. That is, SRL that relates positively to learning outcomes. In accordance, at present it is unclear how to train effective SRL in higher education. The current systematic review breaks down SRL into self-regulatory processes (SRPs) and reviews the evidence for teaching adolescents effective SRPs. Of the wide variety of SRPs which are known in the field, the following were investigated in the studies: metacognitive strategies, motivation, self-efficacy, handling task difficulty and demands, and resource management. The studies included (k = 10; N = 906) generally affirmed that all SRL interventions that were investigated related positively to SRPs. These SRPs also related positively to learning outcomes. Research is needed to advance the field's understanding of how adolescents develop the wide array of effective SRPs.