SNDT Women's University

About: SNDT Women's University is a education organization based out in Mumbai, Maharashtra, India. It is known for research contribution in the topics: Routing protocol & Femtocell. The organization has 252 authors who have published 260 publications receiving 2609 citations. The organization is also known as: Shreemati Nathibai Damodar Thackersey Women's University.

Quantitative In Vitro and In Vivo Evaluation of Intestinal and Blood-Brain Barrier Transport Kinetics of the Plant N-Alkylamide Pellitorine

Abstract: Objective. To evaluate the gut mucosa and blood-brain barrier (BBB) pharmacokinetic permeability properties of the plant N-alkylamide pellitorine. Methods. Pure pellitorine and an Anacyclus pyrethrum extract were used to investigate the permeation of pellitorine through (1) a Caco-2 cell monolayer, (2) the rat gut after oral administration, and (3) the BBB in mice after intravenous and intracerebroventricular administration. A validated bioanalytical UPLC-MS(2) method was used to quantify pellitorine. Results. Pellitorine was able to cross the Caco-2 cell monolayer from the apical-to-basolateral and from the basolateral-to-apical side with apparent permeability coefficients between 0.6 · 10(-5) and 4.8 · 10(-5) cm/h and between 0.3 · 10(-5) and 5.8 · 10(-5) cm/h, respectively. In rats, a serum elimination rate constant of 0.3 h(-1) was obtained. Intravenous injection of pellitorine in mice resulted in a rapid and high permeation of pellitorine through the BBB with a unidirectional influx rate constant of 153 μL/(g·min). In particular, 97% of pellitorine reached the brain tissue, while only 3% remained in the brain capillaries. An efflux transfer constant of 0.05 min(-1) was obtained. Conclusion. Pellitorine shows a good gut permeation and rapidly permeates the BBB once in the blood, indicating a possible role in the treatment of central nervous system diseases.

Navigation based - Intelligent Parking Management System using Queuing theory and IOT

Abstract: The development of devices that can connect to the Internet and transmit data has been a source of inspiration for smart city designs. in a metropolitan cities where the smart cities project are working in progress there are various approaches for making the cities smarter, one of the key features is smart parking, at a peak hour rush it is v difficult for driver to find a parking spaces with an increase and order of traffic, causing traffic congestion and result in wastage of fuel, energy etc. there are various work done,. With liberalization of economy number of vehicle on the road have increased leading to illegal, unorganized parking behavior in at public place, private building, educational campus, corporate campus. Thus, Our main objective is to avoid this unorganized parking system and so for this we can provide the intelligences to parking system which can solved the real time problem of organized and unorganized parking. In this study we have developed a smart parking proposal using queuing theory approach which can be model the parking system as a queue and the evaluation parameter like wait time for user in a queue or in a system can be estimated. Also by using IOT concept, by using wireless sensor node and infrared sensor to provide the real time status of parking lot for user on IOT and suggest the parking lot to avoid wait time in peak hour. The parking space closest to the current location can be found using multiple server single queue system and optimizing the existing system for better user experiences.

Pharmacognostic standardisation and chromatographic fingerprinting of leaves and fruits of zanthoxylum rhetsa

Abstract: Objective: To conduct pharmacognostic standardisation and chromatographic fingerprinting of leaves and fruits of Zanthoxylum rhetsa. Methods: The macroscopic, microscopic and physicochemical evaluation of the crude drugs were conducted as per I. P and WHO guidelines. The chromatographic fingerprint was also developed for the leaves and fruits. Results: The microscopic characteristics of leaves exhibited anomocytic stomata, fibrovascular tissue, lignfied pericyclic fibers and pitted xylem vessels. The fruits exhibited pericarp, oil cells, stone cells, xylem and endosperm. The physicochemical analysis was also conducted. The leaf and fruit powders complied with WHO prescribed limits for microbial load NMT 1× 10 5 CFU/ml and were found to be free from pathogenic organisms. The HPTLC fingerprint was established for methanol extract of leaves and fruits using Dichloromethane: chloroform: ethanol (4:4:1) as solvent and 10% methanolic sulphuric acid as spray reagent. Conclusion: The present work provides referential information for the correct identification and standardisation of the plant.

Multiple contestations: Pandita Ramabai's educational and missionary activities in late nineteenth-century India and abroad

Abstract: Pandita Ramabai, a Brahmin scholar of repute, converted to Christianity during her visit to England for higher studies in the 1880s. Her encounter with Christianity and the Anglican Church, within the imperial, Orientalist and patriarchal framework, was problematic. But Ramabai found her new religion to be a source of spiritual sustenance and basis for an international network of Christian women and men who aided her ambitious residential school for Hindu widows. Ramabai's contestation of the Hindu religion and patriarchy, however, extracted a heavy price in her being socially marginalised and erased from the official histories of Western India. This article explores Ramabai's trail of multiple contestations through the Indian Hindu and imperial Christian terrains to reach her goal of women's empowerment through education.

Advances in encapsulated dermal formulations in chemoprevention of melanoma: An overview.

Abstract: BACKGROUND The three forms of skin cancer are cutaneous malignant melanoma, basal cell carcinoma, and squamous cell carcinoma. Melanoma skin cancer is an aggressive type and one of the most chemotherapy-resistant malignancies. Conventional topical products are beset with limitations, leading to lower efficacy. There is a growing need to develop topical formulations encapsulated in polymeric and lipid nanoparticles, nanoemulsions, dendrimers, and liposomes exhibiting enhanced skin penetration and longer skin retention leading to better efficacy. OBJECTIVE The objective of this article is the screening of reported novel drug encapsulated delivery systems effective topically in melanoma chemoprevention. AIM The scope of this work is to provide an overview pertaining to the development and evaluation of three exemplary drug delivery systems (DDS), namely vesicular, particulate, and specialized emulsions. METHODS Topical drug delivery approaches targeting skin cancer have been reviewed and discussed. The focal point of the article is presentation of insights from published studies. RESULTS This review focuses on the novel delivery systems in chemoprevention of melanoma with discussion highlighting on advances in topical delivery. CONCLUSION Literature indicates that drug-loaded encapsulated topical formulations when compared with conventional dosage forms for skin cancer treatment exhibit greater efficacy and provide benefits like extended drug release, protection of the active ingredient against degradation, and lower skin irritation. Incorporation of phytoconstituents in newer delivery systems will be the way forward for improved topical chemoprevention strategy in melanoma. This has raised hope in making dermal therapy more useful and acceptable.