Transgene SA

About: Transgene SA is a company organization based out in Illkirch-Graffenstaden, France. It is known for research contribution in the topics: Antigen & Genetic enhancement. The organization has 377 authors who have published 296 publications receiving 12537 citations.

Block for the expression of amyloglucosidase in yeast, as well as yeasts containing it

Abstract: The block is characterised in that it comprises: - the amyloglucosidase gene devoid of all or part of its introns; - the DNA sequence containing the signals ensuring the transcription of the amyloglucosidase gene by the yeast; - a coding sequence containing the signal needed for the export of the mature amyloglucosidase into the extracellular medium. More particularly, the invention relates to expression blocks intended for the integration into the genome of an industrial yeast. The invention extends to the simultaneous cotransformation by the blocks for expressing amyloglucosidase and alphaamylase and to the application to fermentation, especially parsnip fermentation.

Antiviral composition of viral protein trans-dominant variants

Abstract: A composition resulting from a combination of trans-dominant variants of two viral proteins from a single virus, and the use thereof as a combination product are disclosed. A vector for expressing the two variants, a eukaryotic cell containing same, and a pharmaceutical composition for treating viral infections, are also disclosed.

Improvments in gene therapy using compositions comprising a polynucleotide and interleukin-10

Abstract: Described is the use of a nuclease inhibitor or of interleukin-10 (IL-10) for the preparation of a therapeutic composition for improving transfection of a polynucleotide into a cell, and to compositions comprising a mixture of polynucleotide and nuclease inhibitor and/or interleukin-10.

Oncolytic viruses and therapeutic molecules

Abstract: The present invention relates to an oncolytic virus encoding a cytidine deaminase (CDAse) polypeptide, a composition comprising it, as well as their use for prophylactic or therapeutic purposes, and more particularly for the treatment of cancer. The present invention also provides a method for treating a disease or a pathologic condition comprising the administration of such an oncolytic virus or composition thereof and a process for preparing such an oncolytic virus.