Institution
Transgene SA
Company•Illkirch-Graffenstaden, France•
About: Transgene SA is a company organization based out in Illkirch-Graffenstaden, France. It is known for research contribution in the topics: Antigen & Genetic enhancement. The organization has 377 authors who have published 296 publications receiving 12537 citations.
Topics: Antigen, Genetic enhancement, Immune system, Gene, Cytotoxic T cell
Papers published on a yearly basis
Papers
More filters
••
14 May 2020
TL;DR: Despite eliciting TB-specific immune responses, none of the investigational regimes conferred a protective effect by standard readouts of TB compared to non-vaccinated controls, while lack of protection by BCG underpinned the stringency of this non-human primate test modality.
Abstract: Tuberculosis (TB) still is the principal cause of death from infectious disease and improved vaccination strategies are required to reduce the disease burden and break TB transmission. Here, we investigated different routes of administration of vectored subunit vaccines based on chimpanzee-derived adenovirus serotype-3 (ChAd3) for homologous prime-boosting and modified vaccinia virus Ankara (MVA) for heterologous boosting with both vaccine vectors expressing the same antigens from Mycobacterium tuberculosis (Ag85B, ESAT6, Rv2626, Rv1733, RpfD). Prime-boost strategies were evaluated for immunogenicity and protective efficacy in highly susceptible rhesus macaques. A fully parenteral administration regimen was compared to exclusive respiratory mucosal administration, while parenteral ChAd3-5Ag prime-boosting and mucosal MVA-5Ag boosting were applied as a push-and-pull strategy from the periphery to the lung. Immune analyses corroborated compartmentalized responses induced by parenteral versus mucosal vaccination. Despite eliciting TB-specific immune responses, none of the investigational regimes conferred a protective effect by standard readouts of TB compared to non-vaccinated controls, while lack of protection by BCG underpinned the stringency of this non-human primate test modality. Yet, TB manifestation after full parenteral vaccination was significantly less compared to exclusive mucosal vaccination.
11 citations
••
TL;DR: In this article, a replication-competent (E3 deleted) Bovine adenovirus-3 (BAV-3) recombinants expressing significant amounts of glycoprotein D (gD) of bovine herpesvirus-1 (a DNA virus).
11 citations
••
TL;DR: This chapter will describe studies done with the antigen MUC1, which has been tested clinically as well as several approaches to antigen-specific immunotherapy of cancer.
Abstract: Several approaches to antigen-specific immunotherapy of cancer antigen-specific immunotherapy of cancer have been tested clinically. In this chapter, we will describe studies done with the antigen MUC1. Tested MUC1 therapeutic vaccines include the following: monoclonal antibodies (MAbs) specific for MUC1; synthetic and recombinant polypeptides from the protein sequence of MUC1; dendritic cells carrying MUC1; RNA and DNA vaccinations; and recombinant viruses carrying the MUC1 DNA sequence. Chemotherapy of cancer aims to be toxic to the cancer cells with manageable side effects to the patient. In contrast, antigen-specific immunotherapy of cancer aims to treat the patient, such that the patient is then able to control and eventually eliminate their cancer cells. It is therefore important to know the immune status of each cancer patient prior to therapy.
10 citations
•
08 Apr 1987TL;DR: In this article, the authors characterized a virus as a vector that comprises at least a portion of the genome of a virus, a gene coding for one of the glycoproteins (gp) of the envelope of the virus responsible for AIDS, as well as the elements providing for the expression of said glycoprotein in cells.
Abstract: Viral vector characterized in that it comprises at least a portion of the genome of a virus, a gene coding for one of the glycoproteins (gp) of the envelope of the virus responsible for AIDS, as well as the elements providing for the expression of said glycoprotein in cells.
10 citations
Authors
Showing all 378 results
Name | H-index | Papers | Citations |
---|---|---|---|
Xuetao Cao | 95 | 509 | 35318 |
Luc Montagnier | 76 | 410 | 30740 |
Simon Wain-Hobson | 62 | 235 | 16013 |
Catherine Tomasetto | 57 | 139 | 10479 |
Rainer Bischoff | 54 | 327 | 10146 |
Richard Lathe | 52 | 172 | 19962 |
Margaret A. Liu | 47 | 97 | 10503 |
Georges Lacaud | 45 | 102 | 5905 |
Jean-Yves Bonnefoy | 44 | 93 | 6368 |
Klaus Schughart | 40 | 157 | 6438 |
Michael Antoniou | 40 | 129 | 5158 |
Andrea Pavirani | 39 | 104 | 8283 |
A Capron | 39 | 129 | 4826 |
Jean-Pierre Lecocq | 37 | 125 | 7122 |
Stéphane Paul | 36 | 199 | 4592 |