Showing papers by "Universidade Federal de Minas Gerais published in 1979"
TL;DR: This investigation contradicts the speculation that the association between this cancer and estrogen use can be explained by swifter diagnosis for estrogen users, misclassification of estrogen-related hyperplasia or treatment of early symptoms of the tumor with estrogen.
Abstract: Our case-control study of the relation between estrogen use and endometrial cancer involved 451 cases and 888 controls. The overall risk of endometrial carcinoma was sixfold for estrogen users as compared with nonusers; long-term users (greater than five years) had a 15-fold risk. Excess risk was present for both diethylstilberstrol and conjugated estrogens. The risk associated with cyclic use was as great as that for continuous use. Increased risk was associated with estrogen use for all histologic grades of the tumor. The risk of advanced-stage carcinoma was fourfold for estrogen users, but rhe confidence interval was wide, and this question requires further study. Finally, this investigation contradicts the speculation that the association between this cancer and estrogen use can be explained by swifter diagnosis for estrogen users, misclassification of estrogen-related hyperplasia or treatment of early symptoms of the tumor with estrogen.
353 citations
TL;DR: Natural occurrence of inierfer on-mediated 2′–5′ adenine oligonucleotide inhibitors in interferon-treated, EMC virus-infected mouse L cells is reported, consistent with the idea that they play a part in the inhibition of virus growth.
Abstract: Until now the inierfer on-mediated 2′–5′ adenine oligonucleotide inhibitors (2–5A) of cell-free protein synthesis have not been detected in intact cells. Here we report their natural occurrence in interferon-treated, EMC virus-infected mouse L cells in amounts consistent with the idea that they play a part in the inhibition of virus growth.
236 citations
TL;DR: A field trial was carried out in the eastern part of the State of Minas Gerais (Brazil) of a vaccine containing killed promastigotes of five stocks of Leishmania, and a high proportion of the vaccinated persons became positive within three months, but circulating antibodies were not detected.
Abstract: A field trial was carried out in the eastern part of the State of Minas Gerais (Brazil) of a vaccine containing killed promastigotes of five stocks of Leishmania. Tests with Montenegro antigen showed that a high proportion of the vaccinated persons became positive within three months, but circulating antibodies were not detected. A proportion of those vaccinated continued to give positive Montenegro reactions for up to three years. Lymphocyte sensitivity tests carried out, on a small sample, three years after vaccination were positive and gave no evidence of immunological depression. No cases of cutaneous or mucocutaneous leishmaniasis occurred in the trial area during the three years of observations.
148 citations
TL;DR: In the complex and confusing epidemiological situation in the Rio Doce Valley it seems unwise to apply traditional specific names to Leishmania of the area, and no species previously incriminated as vectors of mexicana and braziliensis infections in Brazil is found.
Abstract: Dermal leishmaniasis is prevalent in the predominantly settled agricultural areas in the Rio Doce Valley in the eastern part of the State of Minas Gerais, Brazil. The disease has been recorded almost equally in both sexes. Cases have been confirmed in all age groups but youths aged ten to 14 years form the population segment at greatest risk to infection. Cases of single cutaneous lesions, multiple cutaneous lesions and muco-cutaneous lesions have been recorded in the area. Isolates of parasites include representatives of the Leishmania mexicana and L. braziliensis complexes and at least one parasite that does not fit into either category. Infections have not been detected in small mammals (mainly rodents) but about 3% of dogs are infected. The phlebotomine fauna includes no species (or close relatives of species) previously incriminated as vectors of mexicana and braziliensis infections in Brazil. In the complex and confusing epidemiological situation in the Rio Doce Valley it seems unwise to apply traditional specific names to Leishmania of the area.
138 citations
TL;DR: Since the isoenzyme patterns of a stock isolated from a patient with acute disease were similar to those of a silvatic reservoir, its recent introduction into the domiciliary cycle is postulated.
Abstract: 1. The isoenzyme patterns of four soluble enzymes in seven stocks of T. cruzi were determined by electrophoresis. According to their patterns they could be classified into four sets. 2. The isoenzyme patterns of two stocks were influenced by the number of subcultures. 3. Five stocks from man are distinct from those derived from a silvatic reservoir. 4. Since the isoenzyme patterns of a stock isolated from a patient with acute disease were similar to those of a silvatic reservoir, its recent introduction into the domiciliary cycle is postulated.
61 citations
TL;DR: The cholinergic and adrenergic innervation of human minor sublingual buccal and labial salivary glands has been studied with histochemical techniques for localizing acetylcholinesterase and catecholamines to suggest that the autonomic nervous mechanism which regulates salivARY secretion is more elaborate in the major than in the minor salivaries.
Abstract: The cholinergic and adrenergic innervation of human minor sublingual buccal and labial salivary glands has been studied with histochemical techniques for localizing acetylcholinesterase and catecholamines. A rich cholinergic innervation was observed around the acini, blood vessels and some ducts of the three glands.
45 citations
TL;DR: In this article, a case-control study of the relation between estrogen use and endometrial cancer involved 451 cases and 888 controls, finding that the overall risk was sixfold for estrogen users as compared with nonusers; long-term users (greater than five years) had a 15-fold risk.
Abstract: Our case-control study of the relation between estrogen use and endometrial cancer involved 451 cases and 888 controls. The overall risk of endometrial carcinoma was sixfold for estrogen users as compared with nonusers; long-term users (greater than five years) had a 15-fold risk. Excess risk was present for both diethylstilberstrol and conjugated estrogens. The risk associated with cyclic use was as great as that for continuous use. Increased risk was associated with estrogen use for all histologic grades of the tumor. The risk of advanced-stage carcinoma was fourfold for estrogen users, but rhe confidence interval was wide, and this question requires further study. Finally, this investigation contradicts the speculation that the association between this cancer and estrogen use can be explained by swifter diagnosis for estrogen users, misclassification of estrogen-related hyperplasia or treatment of early symptoms of the tumor with estrogen.
43 citations
TL;DR: Tegument samples of Schistosoma mansoni, extracted either by freezing and thawing or saponin, were fractionated in sodium dodecyl sulfate—polyacrylamide gel electrophoresis, and electrophoretic patterns varied if different extraction techniques were used.
27 citations
TL;DR: The results indicate that the cardiac parasympathetic innervation is damaged during the acute phase of experimental Chagas' disease, but returns to normal during the chronic phase in most animals.
26 citations
TL;DR: In this article, it was shown that the coupling between the tunneling motion of one proton and the tunnel motion of another to the Ising model in a transverse field Hamiltonian can lead to large isotope shifts in deuteration even for small values of tunneling intergal.
Abstract: The addition of a ${B}_{\mathrm{ij}}{S}_{i}^{x}{S}_{j}^{x}$-type coupling between the tunneling motion of one proton and the tunneling motion of another to the Ising model in a transverse-field Hamiltonian, or the addition of the probably larger ${S}_{i}^{x}{F}_{i}^{x}{Q}_{i}$-type pseudospin phonon coupling (describing the modulation of the distance between the two equilibrium sites in an O-H \ifmmode\cdot\else\textperiodcentered\fi{} \ifmmode\cdot\else\textperiodcentered\fi{} \ifmmode\cdot\else\textperiodcentered\fi{} O bond by nonpolar phonons), results in a temperature-dependent renormalization of the proton tunneling integral. This is important close to ${T}_{C}$, where the soft-mode frequency vanishes, ${\ensuremath{\omega}}_{\mathrm{crit}}\ensuremath{\rightarrow}0$. This may lead to large isotope shifts in ${T}_{C}$ on deuteration even for small values of the tunneling intergal and may explain some phenomena recently observed in PbHP${\mathrm{O}}_{4}$ and squaric acid as well as the dependence of the effective proton-lattice interaction constant on hydrostatic pressure in K${\mathrm{H}}_{2}$P${\mathrm{O}}_{4}$-type systems. This last effect may be also due to the presence of a ${S}_{i}^{x}{D}_{i}^{x}{{Q}_{i}}^{2}$ term in addition to the Kobayashi ${S}_{i}^{z}{F}_{i}^{z}{Q}_{i}$ term when coupling with polar optic phonons is taken into account. When the lattice motion is so anharmonic that the lattice ions move in a double-well potential, and the proton-lattice coupling so strong that the protons can tunnel in only one out of the two possible lattice configurations, two Curie temperatures may appear.
24 citations
TL;DR: Two flavonoids found in M. peruiferum L.f., presently considered synonymous with M. balsamum, have been located in the latter species and are new natural products.
TL;DR: Apos fazer-se um estudo sobre aspectos gerais de familias, generos e algumas especies de Gymnotoidei e outros peixes eletricos amazonicos, bem como sobre seus habitats and habitos de vida as discussed by the authors.
Abstract: Apos fazer-se um estudo sobre aspectos gerais de familias, generos e algumas especies de Gymnotoidei e outros peixes eletricos amazonicos, bem como sobre seus habitats e habitos de vida, analisam-se os orgaos eletricos e respectivas descargas em varias especies. Procuram estabelecer-se as funcoes da descarga do orgao eletrico. (DOE) na vida do animal, correlacionando-se a mesma com o comportamento e outros eventos. Em seguida, estuda-se a eletrorrecepcao, seus orgaos dos sentidos especiais e processamento cerebral, inclusive o uso de eletrorrecepcao por peixes nao eletricos. Conclui-se o trabalho, Interpretando-se o possivel significado ecologico e pratico dos fatos observados.
TL;DR: It is suggested that the pulmonary edema induced by adrenaline and noradrenaline in unanesthetized rats depends, in part, on a left heart failure and that tachypnea recorded in rats with edema could be related to stimulation of vagal receptors in the lungs.
TL;DR: A group of 215 U.S. and 188 Brazilian urban, middle class children ages 10 and 11 completed a 4-item questionnaire about death and compared the responses were categorized and compared as discussed by the authors.
Abstract: A group of 215 U.S. and 188 Brazilian urban, middle class children ages 10 and 11 completed a 4-item questionnaire about death. The responses were categorized and compared. The authors came to the following conclusions: Significant differences in thoughts about death appear to be cultural and specifically tied to sex role expectations. Patterns of thoughts about death appear to be more consistent among the Brazilian than the U.S. children. It appears that religion strongly influences the Brazilian girls' conceptualizations of death but not the other children's in the sample. Although there were many differences in concepts of death between the U.S. and the Brazilian children, there were also numerous similarities.
TL;DR: Hortia badinii (Rutaceae) contains in the trunkwood skimmianine and 6,7-dimethoxycoumarin, as well as 3-[2-methoxy and 2,6-dimethylpyrano (2′,3′:3,4)phenyl]-1-propanols.
TL;DR: The female of Lutzomyia (LutzomyIA) dispar is described and the male redescribed from specimens laken at Camapua, State of Mato Grosso, Brazil.
Abstract: The female of Lutzomyia (Lutzomyia) dispar is described and the male redescribed from specimens laken at Camapua, State of Mato Grosso, Brazil. One pair was collected in copula. The females of L. dispar bite man avidly when given the opportunity to do so and also attack horses and dogs. The species should be considered as a potential vector of leishmaniasis in certain parts of Brazil.
TL;DR: Infeccoes experimentais de descendentes de Biomphalaria tenagophila de Itajuba, MG (Brasil) foram realizadas utilizando-se a conhecida cepa "LE" de Schistosoma mansoni, isolada em Belo Horizonte, foram chamada a atencao para a necessidade de medidas profilaticas.
Abstract: Infeccoes experimentais de descendentes de Biomphalaria tenagophila de Itajuba, MG (Brasil) foram realizadas utilizando-se a conhecida cepa "LE" de Schistosoma mansoni, isolada em Belo Horizonte. Como controle, utilizou-se B. glabrata de Belo Horizonte, MG. Em consequencia, assinalou-se, pela primeira vez, a infeccao de B. tenagophila de Itajuba, a cepa de S. mansoni adaptada a B. glabrata de Belo Horizonte. Isto e, ao final do experimento, 5 (3,3%) entre os 149 exemplares sobreviventes, infectaram-se. Face ao atual surto industrial da regiao, com grande aporte de migrantes, foi chamada a atencao para a necessidade de medidas profilaticas, em decorrencia da possibilidade de instalacao de foco da doenca no Sul de Minas Gerais.
TL;DR: Nitrogen excretion of germfree snails kept in sterile saline solution during 14 days consists mainly of ammonia and urea in approximately equal amounts.
01 Jan 1979
TL;DR: It is believed that, under similar conditions, Pomacea haustrum - and, by extension, P. canaliculata - may be successfully used in the biological control of the intermediate hosts of S. mansoni, or, at least, of becoming predominant, with no damage to the new ecosystems.
Abstract: In the region of Baldim, MG (Brazil) - a well-known Schistosoma mansoni endemic area where transmission control had already been unsuccessfully attempted through molluscicide, sanitary education and clinical treatment - 5,421 specimens of Pomacea haustrum (Prosobranchia, Pilidae) were introduced into 5 brooks and 2 ditches where Biomphalaria glabrata (primarily) and B. straminea (secondarily) predominated. From 1968 to 1971, the infection rate of B. glabrata by S. mansoni ranged from 2.1% to 11.9%. None of the B. straminea specimens collected, however, were seen to be liberating cercariae of this trematode. After the introduction of Pilidae, only once were two positive B. glabrata specimens (1.8%) detected. A decrease in the planorbide population was observed, as well as an increase in the pomacea density to 20.0 and 121.6 specimens per square meter in the brooks and ditches, respectively. P. haustrum density was estimated by the "quadrat" method. Of the planorbides in the experiment, 65.2% (1,526) were collected from July/68 to July/72 and the rest were obtained after the introduction of the predator-competitor species, as follows: 15.0% (352) in 1976; 16.1% (377) in 1977; and 3.7% (87) in 1978. Although transferred from a lenitic medium (Sete Lagoas, MG), the pomaceae became perfectly adapted to the lotic collections of Baldim, and proved to be capable of replacing the original B. glabrata populations of several biotopes or, at least, of becoming predominant, with no damage to the new ecosystems. Based on the data presented above and the knowledge previously acquired in the study of the biology and ecology of the species, it is believed that, under similar conditions, Pomacea haustrum (Reeve, 1856) - and, by extension, P. lineata (Spix, 1827) and P. canaliculata (Lamarck, 1822), as well as other species from the same genus - may be successfully used in the biological control of the intermediate hosts of S. mansoni.
Journal Article•
TL;DR: Malnutrition altered the free amino acid pool of the NEF by increasing the content of lysine+ornithine, glycine, and aspartic and glutamic acids and lowering that of histidine and threonine and the pools of the remaining amino acids were not altered.
Journal Article•
TL;DR: In this article, a mechanism based on anharmonic elasticity and the critical behavior of the strains around dislocations is proposed for the ciritical static central peak seen in light scattering from K${H}}_{2}$P${\mathrm{O}}_{4}
Abstract: A mechanism, based on anharmonic elasticity and the critical behavior of the strains around dislocations, is proposed for the ciritical static central peak seen in light scattering from K${\mathrm{H}}_{2}$P${\mathrm{O}}_{4}$ and K${\mathrm{H}}_{3}$${(\mathrm{S}\mathrm{e}{\mathrm{O}}_{3})}_{2}$. It is shown that the main source of the anomaly is the ferroelasticity occurring in both crystals, though ferroelectricity in K${\mathrm{H}}_{2}$PO also enhances the scattering.
TL;DR: In this article, the electronic structure of a molecular cluster of argon atoms is obtained by the Xα scattered-wave method and the main features of the bulk electronic structure emerge from the energy spectrum of a cluster which corresponds to one crystal atom and its twelve nearest neighbours.
TL;DR: It is concluded that, probably, the effect of tityustoxin on acetylcholine uptake in slices of rat brain cortex might be due to an increased release of radioactive ACh.
TL;DR: The ultrastructure of a paraganglion found in right atrium of albino mouse close to the superior cava vein is described and the possible physiological role ofParaganglia is discussed.
Abstract: The ultrastructure of a paraganglion found in right atrium of albino mouse close to the superior cava vein is described. A capillary, which occupied the central part of the paraganglion, was surrounded by three chromaffin cells. Two other chromaffin cells were also present, but neither nerve fibers nor nerve endings were seen. The possible physiological role of paraganglia is discussed.