University of North Texas Health Science Center

About: University of North Texas Health Science Center is a education organization based out in Fort Worth, Texas, United States. It is known for research contribution in the topics: Population & Receptor. The organization has 2972 authors who have published 5401 publications receiving 153180 citations. The organization is also known as: UNT Health Science Center & UNTHSC.

Strain and Age Effects on Aqueous Humor Dynamics in the Mouse.

Abstract: Purpose We evaluated differences in aqueous humor dynamics (AHD) among several mouse strains within younger and older age groups Methods Albino (A/J, BALB/cJ) and pigmented (C3H/HeJ, C57-BL/6J) mice (young [2½-4½ months] and aged [10-12 months]) were studied Intraocular pressure (IOP) was measured In cannulated eyes, episcleral venous pressure (Pe) was assessed (blood reflux) Other AHD parameters (outflow facility [C], aqueous humor formation rate [Fin]) were assessed (constant flow infusion) Uveoscleral outflow rate (Fu) was obtained by calculation (Fu(calc)) using the modified Goldmann equation, and in additional eyes (for comparison), by FITC-dextran perfusion (Fu(FITC-dex)) Results Intraocular pressure was higher in pigmented strains, but did not exhibit age-dependence, except in the C57-BL/6J strain Fu(calc) decreased with age in BALB/cJ (↓833%), C3H/HeJ (↓780%), and C57-BL/6J (↓850%) strains In the A/J strain, Fu(calc) decreased with age (↓700%), but not significantly Fin decreased with age in the C3H/HeJ (↓536%) strain In C57-BL/6J and A/J strains, Fin decreased with age, but not significantly C in the BALB/cJ strain increased with age (↑625%) In C3H/HeJ and C57-BL/6J strains, C increased with age, but not significantly Episcleral venous pressure ranged from 60 to 66 mm Hg (albino strains) to 85 to 89 mm Hg (pigmented strains) Pe was not age dependent, but was higher in pigmented animals Conclusions In mouse, Fu and Fin diminish with age C tends to increase as animals progress to middle life There are strain differences in Fu, IOP, C, Fin, and Pe The current findings provide an important foundation for comparisons among different strains in different study reports

Reconstituted HDL: Drug Delivery Platform for Overcoming Biological Barriers to Cancer Therapy

Abstract: Drug delivery to malignant tumors is limited by several factors, including off-target toxicities and suboptimal benefits to cancer patient. Major research efforts have been directed toward developing novel technologies involving nanoparticles (NPs) to overcome these challenges. Major obstacles, however, including, opsonization, transport across cancer cell membranes, multidrug-resistant proteins, and endosomal sequestration of the therapeutic agent continue to limit the efficiency of cancer chemotherapy. Lipoprotein-based drug delivery technology, "nature's drug delivery system," while exhibits highly desirable characteristics, it still needs substantial investment from private/government stakeholders to promote its eventual advance to the bedside. Consequently, this review focuses specifically on the synthetic (reconstituted) high-density lipoprotein rHDL NPs, evaluating their potential to overcome specific biological barriers and the challenges of translation toward clinical utilization and commercialization. This highly robust drug transport system provides site-specific, tumor-selective delivery of anti-cancer agents while reducing harmful off-target effects. Utilizing rHDL NPs for anti-cancer therapeutics and tumor imaging revolutionizes the future strategy for the management of a broad range of cancers and other diseases.

Texas Mexican American adult normative studies: Normative data for commonly used clinical neuropsychological measures for English- and Spanish-speakers.

Abstract: This study aimed to provide normative references for Mexican Americans on neuropsychological measures of cognitive functioning. Data were analyzed from a total of 797 Mexican-Americans recruited across three Texas-based studies with approximately one-half of the participants tested in Spanish. Normative tables include: MMSE, AMNART, WMS-III (Logical Memory I, II; Visual Reproduction I, II; Digit Span), CERAD, RAVLT, Exit25, CLOX 1 & 2, Trail Making Test- A&B, BNT, COWA, and Animal Naming. The norms were stratified by education then age. Normative references were generated for Texas-based Mexican Americans and data may be limited to the population sampled.

Altered regulation of the rostral ventrolateral medulla in hypertensive obese Zucker rats

Abstract: Obese Zucker rats (OZR) have elevated sympathetic nerve activity (SNA) and mean arterial pressure (MAP) compared with lean Zucker rats (LZR). We examined whether altered tonic glutamatergic, angiot...