Institution
University of North Texas Health Science Center
Education•Fort Worth, Texas, United States•
About: University of North Texas Health Science Center is a education organization based out in Fort Worth, Texas, United States. It is known for research contribution in the topics: Population & Receptor. The organization has 2972 authors who have published 5401 publications receiving 153180 citations. The organization is also known as: UNT Health Science Center & UNTHSC.
Topics: Population, Receptor, Health care, Neuroprotection, Cancer
Papers published on a yearly basis
Papers
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TL;DR: In high-risk patients with hypercholesterolemia, rosuVastatin 10 mg was more efficacious than atorvastatin 20 mg at reducing LDL-C, enabling LDL- C goal achievement and improving other lipid parameters.
Abstract: Many patients at high risk of cardiovascular disease do not achieve recommended low-density lipoprotein cholesterol (LDL-C) goals. This study compared the efficacy and safety of low doses of rosuvastatin (10 mg) and atorvastatin (20 mg) in high-risk patients with hypercholesterolemia. A total of 996 patients with hypercholesterolemia (LDL-C ≥ 3.4 and < 5.7 mmol/L [130 and 220 mg/dL]) and coronary heart disease (CHD), atherosclerosis, or a CHD-risk equivalent were randomized to once-daily rosuvastatin 10 mg or atorvastatin 20 mg. The primary endpoint was the percentage change from baseline in LDL-C levels at 6 weeks. Secondary endpoints included LDL-C goal achievement (National Cholesterol Education Program Adult Treatment Panel III [NCEP ATP III] goal < 100 mg/dL; 2003 European goal < 2.5 mmol/L for patients with atherosclerotic disease, type 2 diabetes, or at high risk of cardiovascular events, as assessed by a Systematic COronary Risk Evaluation (SCORE) risk ≥ 5% or 3.0 mmol/L for all other patients), changes in other lipids and lipoproteins, cost-effectiveness, and safety. Rosuvastatin 10 mg reduced LDL-C levels significantly more than atorvastatin 20 mg at week 6 (44.6% vs. 42.7%, p < 0.05). Significantly more patients achieved NCEP ATP III and 2003 European LDL-C goals with rosuvastatin 10 mg compared with atorvastatin 20 mg (68.8% vs. 62.5%, p < 0.05; 68.0% vs. 63.3%, p < 0.05, respectively). High-density lipoprotein cholesterol was increased significantly with rosuvastatin 10 mg versus atorvastatin 20 mg (6.4% vs. 3.1%, p < 0.001). Lipid ratios and levels of apolipoprotein A-I also improved more with rosuvastatin 10 mg than with atorvastatin 20 mg. The use of rosuvastatin 10 mg was also cost-effective compared with atorvastatin 20 mg in both a US and a UK setting. Both treatments were well tolerated, with a similar incidence of adverse events (rosuvastatin 10 mg, 27.5%; atorvastatin 20 mg, 26.1%). No cases of rhabdomyolysis, liver, or renal insufficiency were recorded. In high-risk patients with hypercholesterolemia, rosuvastatin 10 mg was more efficacious than atorvastatin 20 mg at reducing LDL-C, enabling LDL-C goal achievement and improving other lipid parameters. Both treatments were well tolerated.
83 citations
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TL;DR: It is documented that methylene blue reverses the Warburg effect evidenced by the increasing of oxygen consumption and reduction of lactate production in GBM cell lines.
83 citations
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TL;DR: It is shown that by using a high-numerical-aperture objective and high-refractive-index coverslips coated with gold, it is possible to follow rotational motion of 12 actin molecules in muscle with millisecond time resolution.
83 citations
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TL;DR: The aim of this article is to present an overview of mucosal immunity, with the focus on immunity along the gastrointestinal tract; however, similar principles are active in other mucosal tissues.
82 citations
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TL;DR: In this article, the effect of different "doses" of lifelong (>25 years) exercise on arterial stiffening (a hallmark of vascular ageing) in older adults was examined, and it was shown that a less frequent dose of lifelong exercise training (two to three sessions per week for > 30 min) is associated with decreased ventricular afterload and peripheral resistance, while peripheral arterial stiffness is unaffected by any dose of exercise.
Abstract: Key points This study examined the effect of different 'doses' of lifelong (>25 years) exercise on arterial stiffening (a hallmark of vascular ageing) in older adults There are clear dose-dependent effects of lifelong exercise training on human arterial stiffness that vary according to the site and size of the arteries Similar to what we have observed previously with ventricular stiffening, 4-5 days week-1 of committed exercise over a lifetime are necessary to preserve 'youthful' vascular compliance, especially of the large central arteries Casual exercise training of two to three times per week may be sufficient for middle-sized arteries like the carotid to minimize arterial stiffening with ageing However, there is little effect of exercise training on the small-sized peripheral arteries at any dose Abstract Central arterial stiffness increases with sedentary ageing While near-daily, vigorous lifelong (>25 years) endurance exercise training prevents arterial stiffening with ageing, this rigorous routine of exercise training over a lifetime is impractical for most individuals The aim was to examine whether a less frequent 'dose' of lifelong exercise training (four to five sessions per week for > 30 min) that is consistent with current physical activity recommendations elicits similar benefits on central arterial stiffening with ageing A cross-sectional examination of 102 seniors (>60 years old) who had a consistent lifelong exercise history was performed Subjects were stratified into four groups based on exercise frequency as an index of exercise 'dose': sedentary: fewer than two sessions per week; casual exercisers: two to three sessions per week; committed exercisers: four to five sessions per week; and Masters athletes: six to seven sessions per week plus regular competitions Detailed measurements of arterial stiffness and left ventricular afterload were collected Biological aortic age and central pulse wave velocity were younger in committed exercisers and Masters athletes compared to sedentary seniors Total arterial compliance index (TACi) was lower, while carotid β-stiffness index and effective arterial elastance were higher in sedentary seniors compared to the other groups There appeared to be a dose-response threshold for carotid β-stiffness index and TACi Peripheral arterial stiffness was not significantly different among the groups These data suggest that four to five weekly exercise sessions over a lifetime is associated with reduced central arterial stiffness in the elderly A less frequent dose of lifelong exercise (two to three sessions per week) is associated with decreased ventricular afterload and peripheral resistance, while peripheral arterial stiffness is unaffected by any dose of exercise
82 citations
Authors
Showing all 3001 results
Name | H-index | Papers | Citations |
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John T. Potts | 90 | 359 | 29359 |
Evan A. Stein | 80 | 340 | 36392 |
James W. Simpkins | 79 | 431 | 20574 |
Robert J. Gatchel | 79 | 494 | 25583 |
Douglas B. Cines | 79 | 397 | 27792 |
Ranajit Chakraborty | 77 | 407 | 25474 |
Kunlin Jin | 75 | 258 | 23282 |
Bruce Budowle | 70 | 613 | 20227 |
Lisa L. Barnes | 69 | 280 | 20190 |
Abbot F. Clark | 65 | 297 | 13938 |
Yong Fang Kuo | 65 | 447 | 14938 |
Alexander C. Wagenaar | 63 | 241 | 13661 |
David P. Siderovski | 62 | 180 | 19698 |
Yogesh C. Awasthi | 61 | 254 | 12304 |
Ignacy Gryczynski | 61 | 545 | 16705 |