University of Oxford

About: University of Oxford is a education organization based out in Oxford, Oxfordshire, United Kingdom. It is known for research contribution in the topics: Population & Context (language use). The organization has 99713 authors who have published 258108 publications receiving 12972806 citations. The organization is also known as: Oxford University & Oxon..

An integrative theory of intergroup contact

Abstract: Publisher Summary This chapter begins with a re-presentation of Allport's classic hypothesis and shows—with reference to recent cross-sectional and longitudinal surveys— laboratory experiments, and meta-analysis, that many of his original propositions have capably withstood the test of time. It examines Brewer and Miller's, and Gaertner and Dovidio's attempts to extend the contact hypothesis, in both of which categorization processes play a key role. This approach sets the stage for the model, first published in 1986 by Hewstone and Brown. In that model, emphasis was given on identifying the conditions that would allow the generalization of attitudes and behavior change beyond the specific context in which the contact occurs. The chapter discusses the developments of contact theory that occurred in the 1980s and reviews the empirical research instigated by the Hewstone–Brown model. It also reviews the progress to date and attempts a theoretical integration of these models in the light of the large volume of research that they have stimulated.

Regulatory T cells in the control of immune pathology.

Abstract: It is now well established that regulatory T (T(R)) cells can inhibit harmful immunopathological responses directed against self or foreign antigens. However, many key aspects of T(R) cell biology remain unresolved, especially with regard to their antigen specificities and the cellular and molecular pathways involved in their development and mechanisms of action. We will review here recent findings in these areas, outline a model for how T(R) cells may inhibit the development of immune pathology and discuss potential therapeutic benefits that may arise from the manipulation of T(R) cell function.

Biodiversity Conservation and the Eradication of Poverty

Abstract: It is widely accepted that biodiversity loss and poverty are linked problems and that conservation and poverty reduction should be tackled together. However, success with integrated strategies is elusive. There is sharp debate about the social impacts of conservation programs and the success of community-based approaches to conservation. Clear conceptual frameworks are needed if policies in these two areas are to be combined. We review the links between poverty alleviation and biodiversity conservation and present a conceptual typology of these relationships.

The Route of Re-Circulation of Lymphocytes in the Rat

Abstract: The experiments presented in this paper support the idea that the output of small lymphocytes from the thoracic duct of the rat (about 10$^{9}$/day) is normally maintained by a largescale re-circulation of cells from the blood to the lymph. It has been shown that the main channel from blood to lymph lies within the lymph nodes and that small lymphocytes enter the nodes by crossing the walls of a specialized set of blood vessels, the post-capillary venules. In order to trace the fate of small lymphocytes, cells from the thoracic duct of rats were incubated for 1 h in vitro with tritiated adenosine. This labelled the RNA of about 65% of the small lymphocytes and more than 95% of the large lymphocytes; it also labelled the DNA of a proportion of the large lymphocytes. The mixture of small and large labelled lymphocytes was transfused into the blood of two groups of rats which belonged to the same highly inbred strain as the cell donors. At various times after the transfusions the thoracic ducts in one group of rats were cannulated to determine the proportion of labelled cells which could be recovered in the lymph; at corresponding times, the rats in the other group were killed and autoradiographs prepared from their tissues to determine the location of the labelled cells. The radioactive label in the RNA of small lymphocytes was stable enough to ensure that the labelled small lymphocytes which were recovered in the lymph several days after a transfusion were those which had originally been transfused into the blood. When the thoracic duct was cannulated 20 to 27 h after a transfusion, about 70% of the labelled small lymphocytes which had been transfused into the blood could be recovered from the thoracic duct over a 5-day period of lymph collection. During the first 36 to 48 h after cannulation, while the total output of small lymphocytes was falling rapidly, the proportion of labelled cells in the lymph remained approximately constant. The pool of the animal's own cells with which the labelled cells had mixed contained between 1$\cdot $5 and 2 $\times $ 10$^{9}$ small lymphocytes; this was identified as the re-circulating pool. An autoradiographic study showed that after their transfusion into the blood the labelled small lymphocytes 'homed' rapidly and in large numbers into the lymph nodes, the white pulp of the spleen and the Peyer's patches of the intestine. The concentration of labelled cells in other tissues was trivial in comparison. Labelled small lymphocytes were seen penetrating the endothelium of the post-capillary venules in the lymph nodes within 15 min of the start of a transfusion; they were traced into the cortex of the nodes and finally into the medullary lymph sinuses. Labelled small lymphocytes did not migrate into the adult thymus but a few entered the thymus of newborn rats. It was concluded that the re-circulating pool of small lymphocytes was located in the lymphoid tissue, the thymus excepted, and that the rapid 'homing' of cells into the lymph nodes had its basis in the special affinity of small lymphocytes for the endothelium of the post-capillary venules. The interpretation of these experiments was not complicated by the presence of large, as well as of small lymphocytes in the suspensions of labelled cells which were transfused. Other experiments, in which the large lymphocytes alone were labelled with tritiated thymidine, showed that most of them migrated from the blood into the wall of the gut where they assumed the appearance of primitive plasma cells; very few divided to form small lymphocytes.

Hyperkahler Metrics and Supersymmetry

Abstract: We describe two constructions of hyperkahler manifolds, one based on a Legendre transform, and one on a sympletic quotient. These constructions arose in the context of supersymmetric nonlinear σ-models, but can be described entirely geometrically. In this general setting, we attempt to clarify the relation between supersymmetry and aspects of modern differential geometry, along the way reviewing many basic and well known ideas in the hope of making them accessible to a new audience.