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Showing papers by "University of Sydney published in 1970"


Journal ArticleDOI
TL;DR: The results indicate that an immediate response of sensitive plant tissues to temperatures in the chilling range (0 to 10 C) is to depress mitochondrial respiration to an extent greater than that predicted from Q(10) values measured above 10 C.
Abstract: Arrhenius plots of the respiration rates of mitochondria isolated from chilling sensitive plant tissues (tomato and cucumber fruit, and sweet potato roots) showed a linear decrease from 25 C to about 9 to 12 C (with Q10 values of 1.3 to 1.6), at which point there was a marked deviation with an increased slope as temperatures were reduced to 1.5 C (Q10 of 2.2 to 6.3). The log of the respiration rate of mitochondria from chilling resistant tissues (cauliflower buds, potato tubers, and beet roots) showed a linear decrease over the entire temperature range from 25 to 1.5 C with Q10 values of 1.7 to 1.8. Phosphorylative efficiency of mitochondria from all the tissues, as measured by ADP:O and respiratory control ratios, was not influenced by temperatures from 25 to 1.5 C. These results indicate that an immediate response of sensitive plant tissues to temperatures in the chilling range (0 to 10 C) is to depress mitochondrial respiration to an extent greater than that predicted from Q10 values measured above 10 C. The results are also consistent with the hypothesis that a phase change occurs in the mitochondrial membrane as the result of a physical effect of temperature on some membrane component such as membrane lipids.

398 citations


Journal ArticleDOI
TL;DR: It is proposed that the seminiferous tubules secrete a potassium-rich primary secretion, probably by active potassium and bicarbonate transport, and that the rete testis or tubuli recti produce a sodium-rich secondary secretion in relatively larger volumes.
Abstract: Fluid and electrolyte secretion in the rat testis has been studied by micropuncture and catheterization. Three fluids have been collected and analyzed: 1. Rete-testis fluid, obtained by catheterization of the rete testis. 2. Free-flow fluid, obtained by micropuncture of seminiferous tubules. 3. Primary fluid, also obtained by micropuncture but after first filling a tubule segment with oil and allowing new secretion to form and break up the oil column into droplets.

191 citations


Journal ArticleDOI
TL;DR: A neurophysiological theory for binocular single vision and depth discrimination is put forward as a theoretical framework for the construction of the horopter for the cat as well as a region analogous to Panum's fusional area in man.
Abstract: Of binocularly-activated striate neurons only a proportion have their two receptive fields in exactly corresponding positions in the contralateral hemifield Those which are not corresponding are said to show receptive field disparity Because the eyes diverge in the anaesthetized and paralyzed preparation, the binocular receptive fields are horizontally separate With increasing retinal eccentricity there is a gradual decrease in this horizontal separation as well as progressive changes in the local receptive field disparities With increasing horizontal retinal eccentricity there is a progressive increase in horizontal receptive field disparities together with a smaller decrease in vertical disparities Receptive field disparities are relatively unaffected by increasing vertical retinal eccentricity

186 citations


Journal ArticleDOI
TL;DR: In this paper, a typical postparturient rise of parasite egg output occurred in a group of lactating ewes, which carried few inhibited fourth-stage larvae and the rise was associated with a net increase in parasite populations.
Abstract: A typical postparturient rise of parasite egg output occurred in a group of lactating ewes. At parturition these animals carried few inhibited fourth-stage larvae and the rise was associated with a net increase in parasite populations, which did not occur in non-lactating ewes. Lactating ewes whose established parasite populations were effectively removed just prior to parturition showed a similar rise derived entirely from infection acquired during lactation, which was of much greater magnitude than that seen in similarly treated non-lactating animals. Circumstantial evidence of increased fecundity of T. colubriformis females in lactating ewes was also obtained.It was concluded that the postparturient rise of egg output may derive from an increase in adult parasite populations by an increased rate of establishment of newly ingested infective larvae which develop to the adult stage without inhibition, as well as by the resumption of development of previously inhibited fourth-stage larvae. In addition, both newly acquired and established adult female parasites may show increased fecundity.Ewes whose lambs were removed at birth or after a period of lactation showed a rapid fall in faecal egg counts associated with rejection of part of their existing worm burden and a pronounced increase in resistance to new infection.All of the differences observed between lactating and non-lactating ewes in the behaviour of their parasite populations were found to be qualitatively the same as those that have been frequently reported in susceptible and resistant non-reproductive sheep. The hypothesis is suggested, therefore, that the postparturient rise derives from a pronounced but temporary relaxation of immunological control of gastro-intestinal nematode infection associated with the endocrine status of the lactating ewe.

136 citations


Journal ArticleDOI
01 Jan 1970
TL;DR: In this article, the incipient flocculation properties of aqueous polymer dispersions, which are stabilized solely by poly(ethylene oxide) moieties, have been investigated, and it was shown that enthalpic interactions provided the stabilization mechanism in the dispersion studied.
Abstract: The incipient flocculation properties of aqueous polymer dispersions, which are stabilized solely by poly(ethylene oxide) moieties, have been investigated. Flocculation was induced by decreasing the solvency of the dispersion medium for the stabilizing chains. The influence of such factors as the anchor polymer, the disperse phase, the particle size, the surface coverage, and the molecular weight of the stabilizing moieties was examined. Flocculation occurs in dispersion media which are either Θ-solvents for the stabilizing moieties or of better solvency than Θ-solvents. Both aqueous and nonaqueous dispersions, which are stabilized solely by amphipathic nonionic macromolecules, exhibit remarkably parallel flocculation phenomenology. The stability of both types of dispersions is therefore amenable to a common theoretical approach. However, the phase diagrams for aqueous and nonaqueous polymer solutions may be very different. Measurements of the thermodynamic parameters which govern stability demonstrate that, whereas entropic effects may govern stability in nonaqueous systems, enthalpic interactions provide the stabilization mechanism in the aqueous dispersion studied. A general scheme which distinguishes seventeen different thermodynamic situations in the stability-flocculation domain is presented. Stability is shown to originate in entropic effects, enthalpic interactions, or a combination of both.

124 citations


Journal ArticleDOI
15 May 1970-Science
TL;DR: Evidence is presented for the interference by allopurinol of the de novo biosynthesis of uridine 5'-phosphate in man.
Abstract: The administration of allopurinol to patients suffering from hyperuricemia and to normal subjects results in increased excretion of the pyrimidine nucleoside orotidine. Evidence is presented for the interference by allopurinol of the de novo biosynthesis of uridine 5'-phosphate in man.

121 citations


Journal ArticleDOI
TL;DR: A statistical analysis showed that each type of receptor was evenly spaced in the receptor mosaic, but single cone type I tended to occur in pairs.
Abstract: The mean percentages of receptors in the central retina were 14% rods, 32% double cones and 54% single cones. The mean percentages in the periphery were 33% rods, 30% double cones and 37% single cones. Single cones were classified into type I, type II and type III and the ratio of these types was about 5:2:1, respectively, in both central and peripheral retina. A statistical analysis showed that each type of receptor was evenly spaced in the receptor mosaic, but single cone type I tended to occur in pairs. The types of receptor were arranged in a pattern which was in the form of a hexagonal lattice. The pattern in the mosaic is regarded as the outcome of an evenly spaced distribution of the types of receptor. Perhaps pattern in the receptor mosaics of other vertebrate retinae should be interpreted as evenly spaced distributions of the types of receptor present. A method for detecting pattern in receptor mosaics, in which pattern is obscure, is described. A scheme accounting for the formation of the pattern in the chick retina during development is proposed.

116 citations


Journal ArticleDOI
TL;DR: The purpose of this report is to present the clinical, morphological, and biochemical studies of the two patients in whom unique defects were found, in the hope that these studies will contribute to the further understanding of the pathogenesis of similar neurological disorders.
Abstract: INVESTIGATION of an unusual hereditary disease of the nervous system and muscle revealed a marked reduction in the demonstrable cytochrome b content of the muscle mitochondria and other abnormalities of the cytochrome system. The purpose of this report is to present the clinical, morphological, and biochemical studies of the two patients in whom these unique defects were found, in the hope that these studies will contribute to the further understanding of the pathogenesis of similar neurological disorders. Report of Cases CASE 1.— This 46-year-old man was in excellent health until age 33, when his gait became unsteady and his speech became slurred. Shortly thereafter, movements of his hands became clumsy and his handwriting deteriorated, and, within two years, he experienced weakness of the muscles of his legs and shoulders. All of these symptoms were insidiously progressive, but cramplike muscle pains, which persisted for approximately six years after the onset of

114 citations


Journal ArticleDOI
TL;DR: In this paper, bottom photography and dredge samples reveal that living Bryozoa thrive most abundantly at depths of 50-120 fathoms and that catenicelliform Zoaria occur in fine grained sand in quiet water whereas lunulitiform zoaria live in loose, moving, rippled sands.

109 citations


Journal ArticleDOI
01 Jul 1970
TL;DR: In this paper, the Hofmeister series was applied to the flocculation of poly (vinyl acetate) hydrosols, stabilized solely by poly(ethylene oxide) chains, and the results were interpreted in terms of the influence which the positively hydrated ions exert on the structure of the water in their immediate neighborhood.
Abstract: The relevance of ion hydration and the Hofmeister series to the flocculation of poly (vinyl acetate) hydrosols, stabilized solely by poly(ethylene oxide) chains, has been examined. For these enthalpically stabilized dispersions, the flocculation potency of an electrolyte is determined by its ability to convert water into a theta-solvent for the stabilizing moieties. The order of decreasing flocculation effectiveness for the anions studied (SO4= > Cl− > NO3− > CNS− > Br− > I−) parallels that of the Hofmeister series. The order for cations (Rb+ = K+ = Na+ = Cs+ > NH4+ = Sr++ > Li+ = Ca++ = Ba++ = Mg++) is in direct conflict with the postulate that the more highly hydrated ions are the more effective flocculants. In general, monatomic anions and cations are less potent flocculants if their effective primary hydration radius (region A) is large. The results have been interpreted in terms of the influence which the positively hydrated ions exert on the structure of the water in their immediate neighborhood (region B), rather than simply in terms of dehydration of the stabilizing species. Preliminary measurements of the entropy and enthalpy of dilution parameters for poly (ethylene oxide) in electrolyte solutions support this interpretation.

105 citations


Journal ArticleDOI
01 Jan 1970-Lethaia
TL;DR: In this article, seven trace-fossil species are described from the upper part of the Torrowangee Group (Upper Proterozoic) of western New South Wales, and a variety of other traces are illustrated.
Abstract: Seven trace-fossil species are described from the upper part of the Torrowangee Group (Upper Proterozoic) of western New South Wales, and a variety of other traces are illustrated. A few forms occur in the Fowlers Gap Beds, and a more diverse and abundant fauna is recorded from the stratigraphically higher Lintiss Vale Beds. Virtually all the traces are preserved in the plane of bedding, as semi-reliefs. The named trace fossils all come from the Lintiss Vale Beds, and are as follows: Planolites ballandus sp. nov., Planolites? sp., Cochlichnus serpens sp. nov., Gordia? sp., Torrowangea rosei gen. et sp. nov., Phycodes? antecedent sp. nov., and Curvolithus? davidis sp. nov. Three of these species are regarded as feeding burrows (endogene), and are thought to represent the activity of infaunal, worm-like deposit feeders. Others may be either feeding burrows or crawling trails. There are also a few impressions which seem to be rest marks. A discussion of the significance of the trace-fossil occurrences is presented.

Journal ArticleDOI
TL;DR: The reliability of equilibrium constants and enhancement factors, et, for ternary metal-substrate-enzyme complexes determined by proton relaxation rate titration methods has been examined and the degree of accuracy in et should be quite satisfactory for evaluating molecular parameters of the ternARY complex from the magnitude of et.

Journal ArticleDOI
TL;DR: The Great Barrier Reef Province is distinguished from other carbonate areas by very extensive development of shelf reefs, widespread terrigenous facies, and a relatively deep shelf with free water circulation.
Abstract: The Great Barrier Reef Province is distinguished from other carbonate areas by (1) very extensive development of shelf reefs, (2) widespread terrigenous facies, and (3) a relatively deep shelf with free water circulation. The Province occupies 100,000 sq mi of the continental shelf and varies in width from 180 mi in the south to 10 mi at latitude 14° S. Regional deepening from north to south, together with regional variation in reef morphology, permits division of the Province into Northern, Central, and Southern Regions, with boundaries at 16° S., and 20° to 21° S. Geologically, the shelf is an integral part of the Tasman Geosynclinal belt, consisting of submeridional basins and highs. Main reef development has occurred along the tectonic highs. Prolific reef growth in the Northern and Southern Regions is enhanced by oceanic currents impinging directly on the shelf, whereas in the Central Region, sparse growth results partly from less effective oceanic circulation and partly from weaker tidal activity. Local hydrological conditions influence reef morphology, since reefs expand in directions where water (and substrate) conditions are most favorable. Reefs vary in form from concentric platform reefs with shallow lagoons to linear reefs which tend to recurve at the ends, ultimately forming closed ring reefs, similar to platform reefs but characterized by deep lagoons. “Resorbed” reefs are found in areas of unfavorable water conditions. The Northern Region is dominated by linear shelf-edge reefs, the Central Region by platform and resorbed reefs and the Southern Region by a massive development of lagoonal and elongate platform reefs and ring reefs. The regional facies pattern reflects a western terrigenous source, an eastern carbonate source, and a central shelf zone which shows minor influence from either source. Local divergence from this is caused by variation in (1) shelf width and depth, (2) rate of supply and type of material delivered to the shelf, and (3) age and history of the local area. Thus, in the Southern Region where the wide shelf has a deep axial trough, a poor source of terrigenous sediments, and a massive source of carbonate, the facies pattern is characterized by a band of nearshore coarse, relict, terrigenous sands, an axial zone of modern terrigenous muds and a Marginal Shelf with high carbonate (80 percent) sediments. In the Northern Region, the shelf is narrow and has a relatively strong terrigenous source; coarse, coastal terrigenous sands are followed seaward by a wedge of terrigenous muds prograding over coarse relict quartz sands which occur within one mile of individual reefs; inter-reef sediments contain both fine terrigenous and carbonate components. In the Great Barrier Reef Province, contemporary dispersal processes appear to be ineffective, and there is a general lack of accumulation of modern sediment over most of the shelf. Substantial modern deposition is represented only by terrigenous muds adjacent to the coast in the north and in the axial shelf area in the south, and by carbonate sediments on actively forming reefs, in localized areas associated with specific reefs, and in major inter-reef passages. Elsewhere, deposition is limited. This pattern probably will remain stable until advent of a regressive sea-level phase. Marked physical and chemical differences exist between the Great Barrier Reef Province and the Florida-Bahamas Province. In the Bahamas, diverse grain types reflect local environmental variation; in the Great Barrier Reef Province, carbonate grains are almost entirely of skeletal origin and environmental differences are reflected in relative abundance of different skeletal elements. On the other hand, sediment texture and composition as well as reef distribution in both areas reflect primary hydrologic control.

Journal ArticleDOI
TL;DR: Replacement therapy with uridine achieved a striking clinical and haematological remission and is important in preventing the occurrence of mental retardation.
Abstract: SYNOPSIS A case of orotic aciduria is reported and the clinical features reviewed. Replacement therapy with uridine achieved a striking clinical and haematological remission. Early diagnosis is important in preventing the occurrence of mental retardation.

Journal ArticleDOI
TL;DR: A wide variety of polymeric additives were examined for their effects on the crystallization of calcium sulfate dihydrate from aqueous solution as discussed by the authors, and it was postulated that adsorbed polymer molecules acted as immobile impurities on the crystal surface, reducing the step velocity and therefore the crystal growth rate.

Journal ArticleDOI
TL;DR: A study of the nosological status of hypochondriasis which forms part of a wider investigation of this condition (Pilowsky (1966).
Abstract: The controversy over the nosological status of hypochondriasis is a very old one. An examination of the literature reveals an abundance of opinion but very little evidence beyond the anecdotal variety. In the early psychiatric writings, hypochondriasis was for centuries grouped with melancholia and hysteria; at times referred to collectively as “the vapours” (Blackmore ( 1725) Cheyne ( 1733) ) . Most writers addressed themselves to the problem of whether hypochondriasis could be considered an entity distinct from melancholia (Esquirol (1817) Bucknill & T u k e (1858) Griesinger (1867)) although it is clear from Unwins’ (1833) writings that the hysteria-hypochondriasis question was also an issue, concerning which he commented “It has been absurdly enough made a question whether hypochondriasis in men and hysteria in women be the same complaint, as if either of them was an actual specific distemper like small pox, or were at all capable of being considered apart from the subject of it”. In more recent times Kraepelin ( 1904) concluded that hypochondriasis should not be considered an entity but rather “part of neurasthenic insanity”. Others who have concluded that this condition is not an independent disease entity include Bleuler ( 1924) , Ross (1928), Alexander ( 1949) , Fenichel (1955), Ray & Aduani (1962) and Kenyon (1964). Of these only Kenyon has presented evidence based on the investigation of a substantial number of patients and he concludes that hypochondriasis is always part of another condition, usually a depressive illness. Taking the opposite viewpoint axe Allison (1928), Gillespie (1928), Culpin (1931) , Schilde?: (1938), Katzenelbogen (1942), Macalpine (1953) , Stafford-Clark (1962) and Bibring (1954). However, the supporting evidence has tended to be rather slender. The purpose of this paper is to report on a study of the nosological status of hypochondriasis which forms part of a wider investigation of this condition (Pilowsky (1966)).

Journal ArticleDOI
01 Mar 1970-Ecology
TL;DR: In interspecific competition between various strains of Drosophila melanogaster and a vermilion mutant strain of D. simulans in continuous populations, heterogeneity among replicate populations and among generations within populations has been observed.
Abstract: In interspecific competition between various strains of Drosophila melanogaster and a vermilion mutant strain of D. simulans in continuous populations, heterogeneity among replicate populations and among generations within populations has been observed when the fitness of the melanogaster strain was apparently similar to that of simulans vermilion. Larval and adult numbers vary widely among generations, so that differential effects of population density on fitness components of the two species could be an important factor contributing to the observed heterogeneity. The effects of variation in larval density and in proportions of the two species on viability, sex ratio, developmental period and adult body weight have been determined for the Oregon—R—C wild type strain of melanogaster and the standard vermilion strain of simulans. Thirty treatment combinations of larval density (six levels) and species proportions (five levels–two single species, three mixed) were repeated three times at intervals of 1 week. This variable of time had highly significant effects on all components. Results observed in mixed cultures generally were not predictable from results in single species cultures, particularly at high densities. The general effects of density on both species were similar, but there were significant differences between the species that would cause differences in competitive outcome at different densities. Further, the different components showed different responses to density. Species frequency also had significant effects on each component, but these effects were often different for the two species and were different for each component. As the outcome of competition within a generation was both density and frequency dependent, and given as well the significant effects of time, variation among populations and among generation within populations can be expected. The dynamics of interspecific competition in continuous populations will not be simply predictable.

Journal ArticleDOI
R. A. Date1
TL;DR: page 1.
Abstract: page 1. I n t r o d u c t i o n . . . . . . . . . . . . . . . . . . . . . . . . 703 (a) T h e role of legumes in pastures . . . . . . . . . . . . . . 703 (b) N o d u l e formation and effectiveness . . . . . . . . . . . . 704 2. Factors affecting the success of the app l i ed i n o c u l u m . . . . . . 709 (a) I m p o r t a n c e of numbers per seed and inoculant q u a l i t y . . . . 709 (b) F o r m of t h e i n o e u l u m . . . . . . . . . . . . . . . . . . 709 (c) Contact with fertilizers . . . . . . . . . . . . . . . . . . 710 (d) S u r v i v a l on pe l l e ted seed . . . . . . . . . . . . . . . . . 712 3. L ike ly problems in legume establishment . . . . . . . . . . . 714 4. E x a m p l e s of a p p l i c a t i o n of l e g u m e Rhizobium studies . . . . . . 717 (a) Legume inoculant quality control . . . . . . . . . . . . . 7 t 7 (b) The use of l ime-pe l l e t ed seed for aerially sown legumes . . . . 722 (c) Legume inoculant production . . . . . . . . . . . . . . ~ 723 5. R e f e r e n e e s . . . . . . . . . . . . . . . . . . . . . . . . . 724

Journal ArticleDOI
TL;DR: The composition of a mixture of enzymes or isoenzymes may alter after its entry into circulation because of different removal rates for the various components.
Abstract: The homeostasis of circulating enzymes is maintained by an equilibrium between the quantity entering the circulation and the quantity removed per unit of time. Enzymes, like most other circulating substances, are removed at a constant fractional rate with characteristic biological half-lives depending on the enzyme, the isoenzyme, and the species involved. Plasma enzyme activities above normal values may result from increased entry, diminished removal, or both. The composition of a mixture of enzymes or isoenzymes may alter after its entry into circulation because of different removal rates for the various components. These factors should be carefully considered before an "enzyme profile" is regarded as indicative of a disease in a particular organ.

Journal ArticleDOI
TL;DR: In this paper, the authors focus on district assemblies' perspectives of what factors lead to failures in planning and propose reform proposals for reforming the planning system in Ghana, arguing that five major challenges inhibit planning, namely: an inflexible land ownership system, an unresponsive legislative framework, undue political interference, an acute human resource shortage, and the lack of a sustainable funding strategy.
Abstract: Planning has failed to exert effective influence on the growth of human settlements in Ghana. As a result, the growth of cities has been chaotic. The district assemblies, which are the designated planning authorities, are commonly blamed for this failure, yet little attention has been given to district assemblies’ perspectives of what factors lead to failures in planning. This paper attempts to fill this gap. Drawing on fieldwork in Ghana, it argues that, from the perspective of district assemblies, five major challenges inhibit planning, namely: an inflexible land ownership system, an unresponsive legislative framework, undue political interference, an acute human resource shortage, and the lack of a sustainable funding strategy. The paper concludes with proposals for reforming the planning system in Ghana.

Journal ArticleDOI
TL;DR: In this paper, the authors investigated protein synthesis in ripening banana fruit slices and found that during the early part of the climacteric rise which followed ethylene treatment, both the uptake of amino acids into cells, and the rate of incorporation into protein increased.

Journal ArticleDOI
01 Jan 1970-Lithos
TL;DR: Kimberlites are ultramafic rocks in which H 2 O, CO 2 and the residual elements K, Rb, Cs, Sr, Ba, U, Th, Nb etc., are strongly concentrated as discussed by the authors.

Journal ArticleDOI
D.E. Smiles1
TL;DR: In this article, two equivalent analyses that describe the one dimensional process of cake filtration are presented, which permit the prediction of density gradients in the solid material at any time, as it accumulates on the filter membrane.

Journal ArticleDOI
TL;DR: The light-induced increases in activity of enzymes of both the C4-dicarboxylic acid pathway and the Calvin cycle were inhibited by chloramphenicol, consistent with the hypothesis that the increases reflected synthesis of new enzyme on the 70S chloroplast ribosomes.

Journal ArticleDOI
TL;DR: It now becomes necessary to postulate that stimulation can act on electrolyte transport at both primary and secondary levels; at present, however, no data are available to show whether appreciable net water influx can ever occur at the secondary level.
Abstract: Bicarbonate transport in the rat submaxillary main duct has been studied by microperfusion. Bicarbonate was concentrated in the duct lumen against an electrochemical gradient and the equilibrium concentration was estimated to be 56.5 mEq/l±3.1 (S.E.M.,n=11). The secretory mechanism could not be inhibited by 6 mMolar cyanide although such concentrations caused marked inhibition of both net sodium efflux and net potassium influx. Bicarbonate secretion in the main duct was not inhibited by acetazolamide whether applied from the duct lumen or given intravenously. Similarly, the drug was without effect on bicarbonate excretion by the intact gland even when maximum excretory rates had been induced with carbachol. It was concluded that catalytic hydration of carbon dioxide to carbonic acid was not a rate-limiting step in the bicarbonate secretory process. The data did not permit a distinction to be made between a bicarbonate secretory processper se and a process of either H+ reabsorption or OH− secretion. The parasympathomimetic agent, carbachol, when given parenterally was found to increase sharply the net influx of bicarbonate into the microperfused main duct as well as to reduce net sodium efflux and net potassium influx. Previously it had been postulated that final saliva was formed in two stages. First a plasma-like primary secretion was formed at a rate depending on the degree of stimulation, and second, the primary secretion was modified in the gland duct system by reabsorptive and secretory processes whose transport rates were presumed to be independent of the degree of stimulus. It now becomes necessary to postulate that stimulation can act on electrolyte transport at both primary and secondary levels; at present, however, no data are available to show whether appreciable net water influx can ever occur at the secondary level.

Journal ArticleDOI
TL;DR: The findings indicate that the optic tract endings are tonically depolarized in the alert animal and that the depolarization is reduced in non-alertness and reduced further in sleep.
Abstract: 1. Cats with chronically implanted electrodes have been used to study the excitability of the lateral geniculate nucleus (LGN) during alertness, non-alertness and sleep. Excitability has been assessed by the amplitude of the field response in the LGN to electrical stimulation of the optic tract and by the amplitude of the antidromic response in the optic tract evoked by stimulating the LGN. 2. Changes in responsiveness associated with eye movements in the awake animal have been avoided. The change from the alert state to the non-alert state is accompanied by a decrease in the excitability of both the LGN cells and the optic tract nerve endings. 3. Postsynaptic excitability decreases further in slow-wave (SW) sleep but during low-voltage-fast-activity (LVF) sleep it returns to a level that is intermediate between that of alertness and non-alertness. During the ponto-geniculooccipital (PGO) waves of LVF sleep excitability is phasically enhanced to above the alert level. 4. Presynaptic excitability during SW sleep and LVF sleep in the intervals between the PGO waves is less than during non-alertness, but during the waves it returns to the alert level. 5. Our findings indicate that the optic tract endings are tonically depolarized in the alert animal and that the depolarization is reduced in non-alertness and reduced further in sleep. Depolarization is phasically enhanced during the PGO waves. 6. It is suggested that the LGN may be the first site on the visual pathway at which information is modified according to the animal's state of consciousness.


Journal ArticleDOI
TL;DR: Stilwell et al. as discussed by the authors presented a general appraisal of the contribution of the shift and share analysis to the study of regional growth, and advocated more ambitious use of the technique in forecasting because of its ability to handle large amounts of information when used in conjunction with regression analysis.
Abstract: Stilwell F. J. B. (1970) Further thoughts on the shift and share approach, Reg. Studies 4, 451–458. This article is a general appraisal of the contribution of the shift and share analysis to the study of regional growth. The technique itself is shown to have little relevance to the theory of regional growth. However, the organization of information achieved by the shift and share method is useful in the analysis of historical data on either population or employment, and also in forecasting the future regional distribution of economic activity. Many conceptual and empirical limitations are considered, but more ambitious use of the technique in forecasting is advocated because of its ability to handle large amounts of information when used in conjunction with regression analysis.

Journal ArticleDOI
TL;DR: The genePm2 conditioning resistance to powdery mildew in the cultivar Ulka was located on chromosome 5D by monosomic analysis and showed genetic segregation independent of geneLr3 conditioning resistanceto leaf rust on the same chromosome.
Abstract: The genePm2 conditioning resistance to powdery mildew in the cultivar Ulka was located on chromosome 5D by monosomic analysis. It showed genetic segregation independent of geneLr3 conditioning resistance to leaf rust on the same chromosome. Results of telocentric mapping demonstrated thatLr1 was on the long arm of 5D whereasPm2 was very close to the centromere on this arm or, more likely, on the opposite arm. Evidence from chimaeric sectoring favoured the latter alternative.

Journal ArticleDOI
TL;DR: The mean Cl concentration in colloid was 97 mEq/l±20 (S.D.,n=30) and in plasma it was 110±6 mEqs/l (n=6) as discussed by the authors.
Abstract: Micropuncture of rat thyroid follicles has been used to study the chloride and protein composition of the colloid. The mean Cl concentration in colloid was 97 mEq/l±20 (S.D.,n=30) and in plasma it was 110±6 mEq/l (n=6). The mean protein concentration in colloid was 25±16 g-% (n=37) relative to a porcine thyroglobulin standard, and in plasma it was 8.3±3.3 g-% relative to a bovine serum albumin standard.