Institution
Xuzhou Medical College
Education•Xuzhou, China•
About: Xuzhou Medical College is a education organization based out in Xuzhou, China. It is known for research contribution in the topics: Cancer & Cell growth. The organization has 12721 authors who have published 7802 publications receiving 102970 citations.
Topics: Cancer, Cell growth, Apoptosis, Medicine, Protein kinase B
Papers published on a yearly basis
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TL;DR: Recent advances in the understanding of the crosstalks between angiogenesis and CSCs, and their interactions in liver tumor microenvironment and their purpose that an effective anti-angiogenic therapy should also target C SCs for HCC treatment are summarized.
53 citations
TL;DR: The mechanism through which ceRNET_CC is regulated is uncovered, novel roles for the six2/ceR NET_CC axis in regulating the stemness of breast cancer cells are identified, and the possibility of targeting the six1/ceCYP4Z1-3′UTR axis to inhibit breast cancer stem cell (CSC) traits is proposed.
Abstract: The original article [1] contained an error in Fig. 7c whereby the same flow image was accidentally misused for the second and fourth group.
53 citations
TL;DR: This research presents a novel probabilistic procedure called “spot-spot analysis” that allows for real-time analysis of the response of the immune system to foreign substance abuse.
53 citations
TL;DR: Activity evaluations indicated that the selenylation method could improve the activity of sweet potato polysaccharide and its efficacy as a potential therapeutic, which will be the focus of further study.
Abstract: Interest in sweet potato as a functional food is growing. A polysaccharide (SWP) was isolated from the sweet potato tuber and elucidation of its structure as composed of rhamnose, glucose, and galactose undertaken. To improve its activity, selenylation of this novel polysaccharide (Se-SWP) was undertaken by using microwave synthesis. In vitro evaluation showed that the Se-SWP has excellent antioxidant activity on scavenging free radicals and reducing capacity. In vivo antitumor evaluation showed selenylation polysaccharide could effectively inhibit tumor growth (>50%) and adjust immune factor levels in the mice (IL-2, TNF-α, and VEGF). The antidiabetic potential of Se-SWP was tested in STZ-induced diabetic rats. The results indicated that the Se-SWP treatment significantly reduced the levels of malondialdehyde and other disadvantageous factors that were increased by the STZ treatment. Meanwhile, the Se-SWP treatment caused a significant increase in the activities of enzymatic antioxidants and the levels of nonenzymatic antioxidants in the organs of diabetic rats. All of the activity evaluations indicated that the selenylation method could improve the activity of sweet potato polysaccharide and its efficacy as a potential therapeutic, which will be the focus of further study.
53 citations
TL;DR: Quercetin exerts the neuroprotection by enhancing Glo-1 functions in central neurons under chronic HG condition, which may be mediated by activation of Nrf2/ARE pathway; furthermore, the increased NRF2 phosphorylation mediated by PKC activation and/or GSK-3β inhibition may involve in the activation ofNrf2 /ARE pathway.
53 citations
Authors
Showing all 12775 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Liang Wang | 98 | 1718 | 45600 |
| Chang Liu | 97 | 1099 | 39573 |
| Wei Wang | 95 | 3544 | 59660 |
| Yu Liu | 66 | 1262 | 20577 |
| Deling Kong | 65 | 388 | 16515 |
| Zhimou Yang | 61 | 222 | 12522 |
| Xu-Feng Huang | 61 | 332 | 13074 |
| Guangming Lu | 60 | 476 | 13218 |
| Dan Ding | 59 | 212 | 12494 |
| Jian Cao | 58 | 486 | 11074 |
| Yuanjin Zhao | 57 | 328 | 12076 |
| Jie Yang | 56 | 488 | 11382 |
| Lei Wang | 54 | 1076 | 15189 |
| Xiaodong Shi | 52 | 323 | 8910 |
| Wei Pan | 50 | 408 | 9037 |