Institution
Xuzhou Medical College
Education•Xuzhou, China•
About: Xuzhou Medical College is a education organization based out in Xuzhou, China. It is known for research contribution in the topics: Cancer & Cell growth. The organization has 12721 authors who have published 7802 publications receiving 102970 citations.
Topics: Cancer, Cell growth, Apoptosis, Medicine, Protein kinase B
Papers published on a yearly basis
Papers
More filters
TL;DR: The results provided a novel strategy to treat colorectal cancer and enhance the therapeutic efficacy of CAR-modified immune effector cells for solid tumors with combination therapy with regorafenib and CAR-NK-92 cells on established EpCAM-positive tumor xenografts.
Abstract: Adoptive chimeric antigen receptor-modified T or NK cells (CAR-T or CAR-NK) offer new options for cancer treatment. CAR-T therapy has achieved encouraging breakthroughs in the treatment of hematological malignancies. However, their therapeutic efficacy against solid tumors is limited. New regimens, including combinations with chemical drugs, need to be studied to enhance the therapeutic efficacy of CAR-T or NK cells for solid tumors. An epithelial cell adhesion molecule- (EpCAM-) specific second-generation CAR was constructed and transduced into NK-92 cells by lentiviral vectors. Immune effects, including cytokine release and cytotoxicity of the CAR-NK-92 cells against EpCAM-positive colon cancer cells, were evaluated in vitro. Synergistic effects of regorafenib and CAR-NK-92 cells were analyzed in a mouse model with human colorectal cancer xenografts. The CAR-NK-92 cells can specifically recognize EpCAM-positive colorectal cancer cells and release cytokines, including IFN-γ, perforin, and granzyme B, and show specific cytotoxicity in vitro. The growth suppression efficacy of combination therapy with regorafenib and CAR-NK-92 cells on established EpCAM-positive tumor xenografts was more significant than that of monotherapy with CAR-NK-92 cells or regorafenib. Our results provided a novel strategy to treat colorectal cancer and enhance the therapeutic efficacy of CAR-modified immune effector cells for solid tumors.
87 citations
TL;DR: MiR-139-5p not only attenuated the development of breast cancer cells but also mediated drug-resistance by regulating the expression of the downstream target gene Notch1.
86 citations
TL;DR: Wen et al. as discussed by the authors proposed MASTER, a self-attention based scene text recognizer that not only encodes the input-output attention but also learns selfattention which encodes feature-feature and target-target relationships inside the encoder and decoder and owns a great training efficiency because of high training parallelization and a high speed inference because of an efficient memory-cache mechanism.
86 citations
TL;DR: Telerehabilitation should be recommended for patients after TKA because of its comparable pain control and better improvement of functional recovery as compared to face-to-face rehabilitation.
Abstract: IntroductionThe objective of this study was to assess the efficacy of telerehabilitation for patients after total knee arthroplasty (TKA) compared with face-to-face rehabilitation.MethodsMedline, S...
86 citations
TL;DR: The results indicate that whether in global cerebral ischemia in vivo, or in oxygen glucose deprivation (OGD) in vitro, coapplication of muscimol with baclofen can protect neurons from neuronal death through down-regulating the function of N-methyl-d-aspartic acid (NMDA) receptors via attenuating the tyrosine phosphorylation of NR2A subunit.
86 citations
Authors
Showing all 12775 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Liang Wang | 98 | 1718 | 45600 |
| Chang Liu | 97 | 1099 | 39573 |
| Wei Wang | 95 | 3544 | 59660 |
| Yu Liu | 66 | 1262 | 20577 |
| Deling Kong | 65 | 388 | 16515 |
| Zhimou Yang | 61 | 222 | 12522 |
| Xu-Feng Huang | 61 | 332 | 13074 |
| Guangming Lu | 60 | 476 | 13218 |
| Dan Ding | 59 | 212 | 12494 |
| Jian Cao | 58 | 486 | 11074 |
| Yuanjin Zhao | 57 | 328 | 12076 |
| Jie Yang | 56 | 488 | 11382 |
| Lei Wang | 54 | 1076 | 15189 |
| Xiaodong Shi | 52 | 323 | 8910 |
| Wei Pan | 50 | 408 | 9037 |