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Showing papers by "Yahoo! published in 2005"


Journal ArticleDOI
Mahesh Pal1
TL;DR: It is suggested that the random forest classifier performs equally well to SVMs in terms of classification accuracy and training time and the number of user‐defined parameters required byrandom forest classifiers is less than the number required for SVMs and easier to define.
Abstract: Growing an ensemble of decision trees and allowing them to vote for the most popular class produced a significant increase in classification accuracy for land cover classification. The objective of this study is to present results obtained with the random forest classifier and to compare its performance with the support vector machines (SVMs) in terms of classification accuracy, training time and user defined parameters. Landsat Enhanced Thematic Mapper Plus (ETM+) data of an area in the UK with seven different land covers were used. Results from this study suggest that the random forest classifier performs equally well to SVMs in terms of classification accuracy and training time. This study also concludes that the number of user‐defined parameters required by random forest classifiers is less than the number required for SVMs and easier to define.

2,255 citations


Book ChapterDOI
13 Jun 2005
TL;DR: Empirical evidence is given to show that the one-versus-all method using winner-takes-all strategy and the one to one method implemented by max-wins voting are inferior to another one-Versus-one method: one that uses Platt's posterior probabilities together with the pairwise coupling idea of Hastie and Tibshirani.
Abstract: Multiclass SVMs are usually implemented by combining several two-class SVMs. The one-versus-all method using winner-takes-all strategy and the one-versus-one method implemented by max-wins voting are popularly used for this purpose. In this paper we give empirical evidence to show that these methods are inferior to another one-versus-one method: one that uses Platt's posterior probabilities together with the pairwise coupling idea of Hastie and Tibshirani. The evidence is particularly strong when the training dataset is sparse.

639 citations


Patent
James S. Rosen1
18 Oct 2005
TL;DR: In this paper, location-related data and other behavioral and exogenously generated characteristics are used to replace or supplement self-generated profiles in order to enhance the quality and trustworthiness of the matches made using the system and facilitate the inputting of profile information.
Abstract: Systems and methods for social networking. Location-related data (602) and other behavioral and exogenously generated characteristics (404-414, 504-514) are used to replace or supplement self-generated profiles in order to enhance the quality and trustworthiness of the matches (612) made using the system and facilitate the inputting of profile information (400, 500).

487 citations


Patent
15 Mar 2005
TL;DR: In this paper, a trust network is defined for each user, and annotations by any member of a first user's trust network are made visible to the first user during search and/or browsing of the corpus.
Abstract: Computer systems and methods incorporate user annotations (metadata) regarding various pages or sites, including annotations by a querying user and by members of a trust network defined for the querying user into search and browsing of a corpus such as the World Wide Web. A trust network is defined for each user, and annotations by any member of a first user's trust network are made visible to the first user during search and/or browsing of the corpus. Users can also limit searches to content annotated by members of their trust networks or by members of a community selected by the user.

487 citations


Journal ArticleDOI
Pavel Berkhin1
TL;DR: The theoretical foundations of the PageRank formulation are examined, the acceleration of PageRank computing, in the effects of particular aspects of web graph structure on the optimal organization of computations, and in PageRank stability.
Abstract: This survey reviews the research related to PageRank computing. Components of a PageRank vector serve as authority weights for web pages independent of their textual content, solely based on the hyperlink structure of the web. PageRank is typically used as a web search ranking component. This defines the importance of the model and the data structures that underly PageRank processing. Computing even a single PageRank is a difficult computational task. Computing many PageRanks is a much more complex challenge. Recently, significant effort has been invested in building sets of personalized PageRank vectors. PageRank is also used in many diverse applications other than ranking. We are interested in the theoretical foundations of the PageRank formulation, in the acceleration of PageRank computing, in the effects of particular aspects of web graph structure on the optimal organization of computations, and in PageRank stability. We also review alternative models that lead to authority indices similar to PageRan...

479 citations


Journal ArticleDOI
TL;DR: This article investigates the formation of a burgeoning digital pedagogy that roots itself in current adult and social learning theories, while integrating social networking, user experience design strategies, and other emerging technologies into the curriculum to support student learning.
Abstract: Raised in the “always on” world of interactive media, the Internet, and digital messaging technologies, today's student has different expectations and learning styles than previous generations. Thi...

426 citations


Patent
Reiner Kraft1
21 Jul 2005
TL;DR: In this paper, a system and methods for implementing searches using contextual information associated with a Web page (or other document) that a user is viewing when a query is entered is described.
Abstract: Systems and methods are provided for implementing searches using contextual information associated with a Web page (or other document) that a user is viewing when a query is entered. The page includes a contextual search interface that has an associated context vector representing content of the page. When the user submits a search query via the contextual search interface, the query and the context vector are both provided to the query processor and used in responding to the query.

381 citations


Patent
14 Feb 2005
TL;DR: In this paper, the authors present a world model made up of interrelated entity models, each of which corresponds to an entity in the real world, such as a person, place, business, other tangible thing, community, event, or thought.
Abstract: Systems and methods for information retrieval and communication employ a world model. The world model is made up of interrelated entity models, each of which corresponds to an entity in the real world, such as a person, place, business, other tangible thing, community, event, or thought. Each entity model provides a communication channel via which a user can contact a real-world person responsible for that entity model. Entity models also provide feedback information, enabling users to easily share their experiences and opinions of the corresponding real-world entity.

362 citations


Proceedings ArticleDOI
27 Nov 2005
TL;DR: This work introduces two operations on bipartite graphs: identifying similar nodes (Neighborhood formation), and finding abnormal nodes (Anomaly detection), and proposes algorithms to compute the neighborhood for each node using random walk with restarts and graph partitioning.
Abstract: Many real applications can be modeled using bipartite graphs, such as users vs. files in a P2P system, traders vs. stocks in a financial trading system, conferences vs. authors in a scientific publication network, and so on. We introduce two operations on bipartite graphs: 1) identifying similar nodes (Neighborhood formation), and 2) finding abnormal nodes (Anomaly detection). And we propose algorithms to compute the neighborhood for each node using random walk with restarts and graph partitioning; we also propose algorithms to identify abnormal nodes, using neighborhood information. We evaluate the quality of neighborhoods based on semantics of the datasets, and we also measure the performance of the anomaly detection algorithm with manually injected anomalies. Both effectiveness and efficiency of the methods are confirmed by experiments on several real datasets.

357 citations


Patent
10 Feb 2005
TL;DR: In this paper, a wireless communication method for electronic dating, social networking, and other communication applications is presented, which includes a first wireless device, receiving one or more wireless device identifications associated with other wireless devices, and transmitting at least one of the identifications from the first wireless devices to a remote computer system.
Abstract: Embodiments of the present invention include improved communication system and methods. In one embodiment, the present invention includes a wireless communication method comprising, on a first wireless device, receiving one or more wireless device identifications associated with one or more other wireless devices, and transmitting at least one of the one or more wireless device identifications from the first wireless device to a remote computer system, and on the remote computer system, receiving the at least one wireless device identification, and accessing information associated with the at least one wireless device identification. Embodiments of the present invention may be used for electronic dating, social networking and other communication applications.

336 citations


Journal ArticleDOI
15 May 2005-Spine
TL;DR: This is a first study to document that a cervical disc replacement arthroplasty procedure maintains adjacent level IDPs and reconstruction level kinematics near the preoperative values and may provide an alternative to conventional surgical management of cervical discogenic pathology decreasing the incidence of symptomatic transition syndrome.
Abstract: Study Design. In vitro investigation of cervical adjacent level intradiscal pressures (IDPs) following a total disc replacement arthroplasty. Objectives. The current in vitro study was undertaken to compare adjacent level IDPs and operative level kinematics following a cervical arthroplasty versus an arthrodesis procedure. Summary of Background Data. Clinical data indicate the incidence of symptomatic transition syndrome to be as high as 3% annually following a cervical interbody arthrodesis. Recent developments in the motion preservation technology should, in theory, minimize transition syndrome at the adjacent levels. Methods. A total of 10 human cadaveric cervical spines were used in this investigation. Following intact analysis, all specimens were sequentially reconstructed at C5–C6 with 1) total disc replacement (TDR), 2) allograft dowel, and 3) allograft dowel + anterior cervical plate. Testing was performed in displacement control under axial rotation, flexion/extension, and lateral bending loading modes. IDPs were recorded at C4–C5 and C6–C7 whereas peak range of motion (ROM) and NZ were monitored at C5–C6 level. Results. Similar IDPs were recorded between the intact condition and a TDR reconstruction at both adjacent levels under all loading modes (P > 0.05). However, the C4–C5 IDP values produced under flexion/extension testing for both arthrodesis treatments were significantly higher than the means obtained for the intact and disc replacement groups (P 0.05). Conclusion. This is a first study to document that a cervical disc replacement arthroplasty procedure maintains adjacent level IDPs and reconstruction level kinematics near the preoperative values. Consequently, total disc replacement may provide an alternative to conventional surgical management of cervical discogenic pathology decreasing the incidence of symptomatic transition syndrome.

Patent
08 Sep 2005
TL;DR: In this article, the user can set a presence and/or a communicaiton mode, which the client device communicates to other devices directly or via an inter-midiary server.
Abstract: A system and method-are directed towards providing a user interface (21) for controlling a communication mode for a client device (103). The interface enables user to set a presence and/or a communicaiton mode, which the client device communicates to other devices directly or via an intermidiary server (106). The presence generally reflects the user's availability, communication capability, desire to communicate, and the like. The presence can be directly or indirectly associated with the communicaiton mode, which can comprise SMS, IM, email, voice, and the like, The interface includes a contact list and enables the user to select a mode to communicate with a contact. The communication modes associated with each contact can also be incorporated into and displayed (21 in an email address book. This interface also indicates the communication mode of each incoming and outgoing (228) message conversations with one or more other client devices.

Proceedings ArticleDOI
07 Jun 2005
TL;DR: An unsupervised learning approach using K-way spectral clustering that disambiguates authors in citations is proposed that utilizes three types of citation attributes: co-author names, paper titles, and publication venue titles.
Abstract: An author may have multiple names and multiple authors may share the same name simply due to name abbreviations, identical names, or name misspellings in publications or bibliographies (citations). This can produce name ambiguity which can affect the performance of document retrieval, web search, and database integration, and may cause improper attribution of credit. Proposed here is an unsupervised learning approach using K-way spectral clustering that disambiguates authors in citations. The approach utilizes three types of citation attributes: co-author names, paper titles, and publication venue titles. The approach is illustrated with 16 name datasets with citations collected from the DBLP database bibliography and author home pages and shows that name disambiguation can be achieved using these citation attributes

Journal ArticleDOI
TL;DR: The external intercostals and the parasternal inter costals have an inspiratory function during breathing, whereas the internal interosseous intercostal and the triangularis sterni have an expiratory function.
Abstract: The mechanical advantages of the external and internal intercostals depend partly on the orientation of the muscle but mostly on interspace number and the position of the muscle within each interspace. Thus the external intercostals in the dorsal portion of the rostral interspaces have a large inspiratory mechanical advantage, but this advantage decreases ventrally and caudally such that in the ventral portion of the caudal interspaces, it is reversed into an expiratory mechanical advantage. The internal interosseous intercostals in the caudal interspaces also have a large expiratory mechanical advantage, but this advantage decreases cranially and, for the upper interspaces, ventrally as well. The intercartilaginous portion of the internal intercostals (the so-called parasternal intercostals), therefore, has an inspiratory mechanical advantage, whereas the triangularis sterni has a large expiratory mechanical advantage. These rostrocaudal gradients result from the nonuniform coupling between rib displacement and lung expansion, and the dorsoventral gradients result from the three-dimensional configuration of the rib cage. Such topographic differences in mechanical advantage imply that the functions of the muscles during breathing are largely determined by the topographic distributions of neural drive. The distributions of inspiratory and expiratory activity among the muscles are strikingly similar to the distributions of inspiratory and expiratory mechanical advantages, respectively. As a result, the external intercostals and the parasternal intercostals have an inspiratory function during breathing, whereas the internal interosseous intercostals and the triangularis sterni have an expiratory function.

Proceedings ArticleDOI
07 Aug 2005
TL;DR: Two new support vector approaches for ordinal regression are proposed, which optimize multiple thresholds to define parallel discriminant hyperplanes for the ordinal scales and guarantee that the thresholds are properly ordered at the optimal solution.
Abstract: In this paper, we propose two new support vector approaches for ordinal regression, which optimize multiple thresholds to define parallel discriminant hyperplanes for the ordinal scales. Both approaches guarantee that the thresholds are properly ordered at the optimal solution. The size of these optimization problems is linear in the number of training samples. The SMO algorithm is adapted for the resulting optimization problems; it is extremely easy to implement and scales efficiently as a quadratic function of the number of examples. The results of numerical experiments on benchmark datasets verify the usefulness of these approaches.

Journal ArticleDOI
TL;DR: The more recent studies consistently support that the Mediterranean diet, based in virgin olive oil, is compatible with a healthier ageing and increased longevity.
Abstract: 1. Ageing represents a great concern in developed countries because the number of people involved and the pathologies related with it, like atherosclerosis, morbus Parkinson, Alzheimer's disease, vascular dementia, cognitive decline, diabetes and cancer. 2. Epidemiological studies suggest that a Mediterranean diet (which is rich in virgin olive oil) decreases the risk of cardiovascular disease. 3. The Mediterranean diet, rich in virgin olive oil, improves the major risk factors for cardiovascular disease, such as the lipoprotein profile, blood pressure, glucose metabolism and antithrombotic profile. Endothelial function, inflammation and oxidative stress are also positively modulated. Some of these effects are attributed to minor components of virgin olive oil. Therefore, the definition of the Mediterranean diet should include virgin olive oil. 4. Different observational studies conducted in humans have shown that the intake of monounsaturated fat may be protective against age-related cognitive decline and Alzheimer's disease. 5. Microconstituents from virgin olive oil are bioavailable in humans and have shown antioxidant properties and capacity to improve endothelial function. Furthermore they are also able to modify the haemostasis, showing antithrombotic properties. 6. In countries where the populations fulfilled a typical Mediterranean diet, such as Spain, Greece and Italy, where virgin olive oil is the principal source of fat, cancer incidence rates are lower than in northern European countries. 7. The protective effect of virgin olive oil can be most important in the first decades of life, which suggests that the dietetic benefit of virgin olive oil intake should be initiated before puberty, and maintained through life. 8. The more recent studies consistently support that the Mediterranean diet, based in virgin olive oil, is compatible with a healthier ageing and increased longevity. However, despite the significant advances of the recent years, the final proof about the specific mechanisms and contributing role of the different components of virgin olive oil to its beneficial effects requires further investigations.

Journal ArticleDOI
TL;DR: This review article provides an overview on the most recent advances on the role of ErbB receptors and growth factors of the epidermal growth factor (EGF)-family of peptides in cancer pathogenesis and progression.
Abstract: This review article provides an overview on the most recent advances on the role of ErbB receptors and growth factors of the epidermal growth factor (EGF)-family of peptides in cancer pathogenesis and progression. The ErbB tyrosine kinases and the EGF-like peptides form a complex system. In fact, the interactions occurring between receptors and ligands of these families affect the type and the duration of the intracellular signals that derive from receptor activation. Interestingly, activation of ErbB receptors is also driven by different classes of membrane receptor, suggesting that ErbB kinases can amplify growth promoting signals carried by different pathways. The importance of ErbB receptors and EGF-like peptides in development of organs and tissues has been demonstrated by using different mouse models. In vitro and in vivo studies have also shown that ErbB receptors and their ligands can act as transforming genes. However, evidence suggests that cooperation of different receptors and ligands is necessary to induce a fully transformed phenotype. Indeed, co-expression of different ErbB receptors and EGF-like growth factors is a common phenomenon in human primary carcinomas. This observation suggests that the growth and the survival of carcinoma cells is sustained by a network of receptors/ligands of the ErbB family. In this respect, the contemporary expression of different ErbB tyrosine kinases and/or EGF-like growth factors in human carcinomas might also affect tumor response to target based agents directed against the ErbB receptor/ligand system.

Journal ArticleDOI
TL;DR: For Crohn disease limited to the ileum, US may represent a valid alternative to the small-bowel series, while for colonic involvement US may be useful in ruling out the diagnosis.
Abstract: PURPOSE: To evaluate the accuracy of ultrasonography (US) in the detection of Crohn disease in adults by systematically reviewing both cohort studies (those including patients whose clinical characteristics were consistent with those caused by an inflammatory bowel disease) and case-control studies (those in which patients with Crohn disease were compared with patients with other bowel diseases or healthy control subjects). MATERIALS AND METHODS: The MEDLINE, EMBASE, and Cochrane Library databases were used to retrieve all the cross-sectional studies that assessed the diagnostic accuracy of US against that of one of several predefined reference standards (ie, radiologic, endoscopic, or histologic findings). The studies that fulfilled the inclusion criteria were identified, and their methodological quality was evaluated. Of the 2860 primary studies identified, two case-control and five cohort series fulfilled the inclusion criteria. Statistical analysis was performed by using the summary receiver operating...

Patent
Hongche Liu1, Anand Madhavan1
02 Jun 2005
TL;DR: In this article, a system including a plurality of web servers configured to serve base content and relevant content to a user system, a set of additional-content servers configured to serve the relevant content if units in the user profile match units associated with the relevant contents, and a parsing server configured to extract the units in user profile from the base content requested by the user and generate a ranked list of the units.
Abstract: A system including a plurality of web servers configured to serve base content and relevant content to a user system; a set of additional-content servers configured to serve the relevant content to the web servers if units in the user profile match units associated with the relevant content; a parsing server configured to extract the units in the user profile from the base content requested by the user and generate a ranked list of the units in the user profile; and a unit-matching module configured to determine whether the units in the user profile match units associated with the relevant content if the user requests the base content, wherein the web servers are configured to serve the base content and the relevant content if the units in the user profile match units associated with the relevant content.

Journal ArticleDOI
TL;DR: Early data support the continued use of the Durasul highly cross-linked polyethylene acetabular liner for total hip arthroplasty, and the annual linear wear rate was 45% of that seen with the conventionalpolyethylene liner.
Abstract: Background: Highly cross-linked polyethylene is currently the most common articulation surface used for total hip arthroplasty. The hypothesis of the present study was that the Durasul highly cross-linked polyethylene acetabular liner would have less wear at five years than would a conventional polyethylene liner used in association with the same total hip replacement system. Methods: Forty-three consecutive patients (fifty hips) underwent total hip replacement with an uncemented titanium porous-coated metal cup and a Durasul liner that was mated with a 28-mm cobalt-chromium femoral head. Thirty-one patients (thirty-seven hips) were followed for at least five years. Thirty-five other patients (thirty-seven hips) underwent total hip arthroplasty with the same system but with a conventional polyethylene liner, and these patients also were followed for five years. Clinical assessment was performed with use of the Harris hip score and a patient self-assessment examination. Radiographic analysis included measurements of acetabular component position, fixation, and osteolysis. Femoral head penetration of the Durasul liners was compared with that of the conventional liners. Results: The clinical results as determined on the basis of Harris hip scores and patient self-assessment examinations did not differ between the Durasul group and the control group. The mean bedding-in penetration was 0.054 ± 0.07 mm for the Durasul group and 0.059 ± 0.154 mm for the control group. The subsequent penetration, with elimination of the bedding-in wear, resulted in a linear wear rate of 0.029 ± 0.02 mm per year for the Durasul group, compared with 0.065 ± 0.03 mm per year for the control group (p < 0.005). The annual penetration at one and five years was 0.074 mm and 0.011 mm, respectively, for the Durasul group, compared with 0.151 mm and 0.04 mm, respectively, for the control group. Conclusions: While the qualitative wear pattern of the highly cross-linked polyethylene liner was the same as that of the conventional polyethylene liner, the annual linear wear rate was 45% of that seen with the conventional polyethylene liner. Therefore, we believe that these early data support the continued use of this highly cross-linked polyethylene liner for total hip arthroplasty. Level of Evidence: Therapeutic Level III. See Instructions to Authors for a complete description of levels of evidence.

Journal ArticleDOI
Joyce Chi Yee Chan1, Ole Knudson2, Faye Wu2, John Morser2, William P. Dole2, Qingyu Wu2 
TL;DR: It is shown that corin-deficient (Cor-/-) mice develop normally during embryogenesis and survive to postnatal life, establishing corin as the physiological pro-ANP convertase and indicating that cor in deficiency may contribute to hypertensive heart disease.
Abstract: Atrial natriuretic peptide (ANP) is a cardiac hormone that regulates blood pressure. In cardiomyocytes, the hormone is synthesized as a precursor, proatrial natriuretic peptide (pro-ANP), which is proteolytically converted to active ANP. Corin is a cardiac transmembrane serine protease that has been shown to process pro-ANP in vitro, but its physiological importance had not been established. Here, we show that corin-deficient (Cor-/-) mice develop normally during embryogenesis and survive to postnatal life. Cor-/- mice have elevated levels of pro-ANP but no detectable levels of ANP as compared with WT littermates. Infusion of an active recombinant soluble corin transiently restores pro-ANP conversion, resulting in the release of circulating biologically active ANP. Using radiotelemetry to assess blood pressure, we find that Cor-/- mice have spontaneous hypertension as compared with WT mice, and it is enhanced after dietary salt loading. Pregnant Cor-/- mice demonstrate late-gestation proteinuria and enhanced high blood pressure during pregnancy. In addition, Cor-/- mice exhibit cardiac hypertrophy resulting in a mild decline in cardiac function later in life. Thus, our data establish corin as the physiological pro-ANP convertase and indicate that corin deficiency may contribute to hypertensive heart disease.

Patent
Eckart Walther1, Qi Lu1, David Ku, Kevin Lee1, Chung-Man Tam1, Ali Diab 
15 Mar 2005
TL;DR: In this paper, the authors describe a system where users can annotate content items found in a corpus such as the World Wide Web and search their annotations or limit searches to documents they have annotated.
Abstract: Computer systems and methods allow users to annotate content items found in a corpus such as the World Wide Web. Annotations, which can include any descriptive and/or evaluative metadata related to a document, are collected from a user and stored in association with that user. Users are able to annotate and view their annotations for any document they encounter while interacting with the corpus, including hits returned in a search of the corpus. Users are also able to search their annotations or to limit searches to documents they have annotated. Metadata from annotations can also be aggregated across users and aggregated metadata applied in generating search results.

Patent
14 Nov 2005
TL;DR: In this paper, a synchronization server includes logic operable to engage in a first synchronization session with a client device, wherein client modifications and server modifications may be exchanged based, at least in part, on synchronization data stored locally.
Abstract: In one example, a synchronization server includes logic operable to engage in a first synchronization session with a client device, wherein client modifications and server modifications may be exchanged based, at least in part, on synchronization data stored locally. The synchronization server further includes logic operable to initiate a query of a remote database (e.g., having data associated with the synchronization data) to determine differences between the synchronization data stored locally and associated data stored remotely. The synchronization server is further operable to initiate an exchange of further server modifications based on the differences between the synchronization data stored locally and the associated data stored remotely. In one example, the server may engage in a second synchronization session with the client device to update the client device with differences to the synchronization data stored locally and the remote database.

Patent
Ali Diab1, John Kim1, David Ku1, Kevin Lee1, Qi Lu1, Eckart Walther1, Benjamin Garrett1, Scott A. Gatz1, Jason Douglas1 
15 Mar 2005
TL;DR: In this article, personal portal pages for individual users are integrated with web content syndication, where the user can select the syndication option and thereby subscribe their personal portal page to that syndication feed.
Abstract: Personal portal pages for individual users are integrated with web content syndication. For example, when a search query is received from the user, a list of hits is generated. For each hit, it is determined whether there is an associated syndication feed, such as an RSS feed. The list of hits is displayed for the user, and a syndication option is included for each hit that has an associated syndication feed. The user can select the syndication option and thereby subscribe their personal portal page to that syndication feed. In some embodiments, the user may also be able to select syndication feeds for subscription via an alternative interface

Journal ArticleDOI
TL;DR: Increased ADMA plasma levels are associated with unfavorable pulmonary hemodynamics and worse outcome in patients with idiopathic pulmonary arterial hypertension.
Abstract: Objective— We explored the potential role of the endogenous NO synthase inhibitor asymmetrical dimethylarginine (ADMA) in patients with idiopathic pulmonary arterial hypertension (IPAH). Method and...

Journal ArticleDOI
Jay Pravda1
TL;DR: A new pathogenesis termed "Radical Induction Theory" is proposed to explain the genesis and progression of ulcerative colitis and states that excess un-neutralized hydrogen peroxide diffuses through cell membranes to the extracellular space where it is converted to the highly damaging hydroxyl radical resulting in oxidative damage to structures comprising the colonic epithelial barrier.
Abstract: To propose a new pathogenesis called Radical Induction to explain the genesis and progression of ulcerative colitis (UC). UC is an inflammatory bowel disease. Colonic inflammation in UC is mediated by a buildup of white blood cells (WBCs) within the colonic mucosal lining; however, to date there is no answer for why WBCs initially enter the colonic mucosa to begin with. A new pathogenesis termed "Radical Induction Theory" is proposed to explain this and states that excess un-neutralized hydrogen peroxide, produced within colonic epithelial cells as a result of aberrant cellular metabolism, diffuses through cell membranes to the extracellular space where it is converted to the highly damaging hydroxyl radical resulting in oxidative damage to structures comprising the colonic epithelial barrier. Once damaged, the barrier is unable to exclude highly immunogenic fecal bacterial antigens from invading the normally sterile submucosa. This antigenic exposure provokes an initial immune response of WBC infiltration into the colonic mucosa. Once present in the mucosa, WBCs are stimulated to secrete toxins by direct exposure to fecal bacteria leading to mucosal ulceration and bloody diarrhea characteristic of this disease.

Journal Article
TL;DR: This review is mainly focused on the diseases that have attracted most attention with respect to liposomal drug delivery and have therefore yielded most progress, namely cancer, antibacterial and antifungal disorders.
Abstract: Liposomes have been widely investigated since 1970 as drug carriers for improving the delivery of therapeutic agents to specific sites in the body. As a result, numerous improvements have been made, thus making this technology potentially useful for the treatment of certain diseases in the clinics. The success of liposomes as drug carriers has been reflected in a number of liposome-based formulations, which are commercially available or are currently undergoing clinical trials. The current pharmaceutical preparations of liposome-based therapeutic systems mainly result from our understanding of lipid-drug interactions and liposome disposition mechanisms. The insight gained from clinical use of liposome drug delivery systems can now be integrated to design liposomes that can be targeted on tissues, cells or intracellular compartments with or without expression of target recognition molecules on liposome membranes. This review is mainly focused on the diseases that have attracted most attention with respect to liposomal drug delivery and have therefore yielded most progress, namely cancer, antibacterial and antifungal disorders. In addition, increased gene transfer efficiencies could be obtained by appropriate selection of the gene transfer vector and mode of delivery.

Journal ArticleDOI
TL;DR: Treatment options as well as indications and techniques to address osseous defects of the humeral head and glenoid and the management of anterior shoulder instability are reviewed.
Abstract: The diagnosis and treatment of osseous deficiencies associated with anterior shoulder instability have been a challenge to physicians for centuries. Whereas historical goals centered on the stable reduction and prevention of recurrent dislocation, current standards of success are predicated on the restoration of motion and strength and the return to functional activities, including competitive athletics. Reestablishment of anterior shoulder stability thus requires the recognition of osseous defects of the humeral head and glenoid, as well as a thorough understanding of the available treatment options in the context of a disciplined treatment algorithm. Although many surgical procedures have been described for the management of osseous deficiencies in association with anterior shoulder instability, in the authors' experience, such procedures are seldom necessary. The purpose of this summary is to review treatment options as well as indications and techniques to address these bony deficiencies.

Patent
Jianing Hu1, Pasha Sadri
28 Oct 2005
TL;DR: In this paper, a trip planner is provided for creating, modifying, categorizing, and sharing online trip plans, which includes a list of items such as hotels, restaurants, and tourist attractions selected from a travel guide or provided by a user.
Abstract: A trip planner is provided for creating, modifying, categorizing, and sharing online trip plans. A trip plan includes a list of items such as hotels, restaurants, and tourist attractions selected from a travel guide or provided by a user. An item can have a street address for positioning the item on a map, an image and description of the item, and other metadata assigned by the user, such as tags and notes. The trip planner can generate an itinerary listing the items, and a corresponding map showing the locations of the items. A trip plan can be shared with other users, who can locate the trip plan by searching for the tags or other metadata.

Journal ArticleDOI
TL;DR: A phylogenetic analysis of habitat specificity of 35 western Amazonian species from the genera Protium, Crepidospermum, and Tetragastris shows association with terrace soils to be the probable ancestral state in the group, with subsequent speciation events onto clay and white‐sand soils suggesting edaphic heterogeneity was an important driver of speciation in the Protieae in the Amazon basin.
Abstract: Environmental heterogeneity in the tropics is thought to lead to specialization in plants and thereby contribute to the diversity of the tropical flora. We examine this idea with data on the habitat specificity of 35 western Amazonian species from the genera Protium, Crepidospermum, and Tetragastris in the monophyletic tribe Protieae (Burseraceae) mapped on a molecular-based phylogeny. We surveyed three edaphic habitats that occur throughout terra firme Amazonia: white-sand, clay, and terrace soils in eight forests across more than 2000 km in the western Amazon. Twenty-six of the 35 species were found to be associated with only one of three soil types, and no species was associated with all three habitats; this pattern of edaphic specialization was consistent across the entire region. Habitat association mapped onto the phylogenetic tree shows association with terrace soils to be the probable ancestral state in the group, with subsequent speciation events onto clay and white-sand soils. The repeated gain of clay association within the clade likely coincides with the emergence of large areas of clay soils in the Miocene deposited during the Andean uplift. Character optimizations revealed that soil association was not phylogenetically clustered for white-sand and clay specialists, suggesting repeated independent evolution of soil specificity is common within the Protieae. This phylogenetic analysis also showed that multiple cases of putative sister taxa with parapatric distributions differ in their edaphic associations, suggesting that edaphic heterogeneity was an important driver of speciation in the Protieae in the Amazon basin.