Zonguldak Karaelmas University

About: Zonguldak Karaelmas University is a based out in . It is known for research contribution in the topics: Population & Copolymer. The organization has 1939 authors who have published 4296 publications receiving 62466 citations.

Predictors of outcome after acute ischemic stroke.

Abstract: The aim of this study was to determine which variables should be the predictors for clinical outcome at discharge and sixth month after acute ischemic stroke. Methods– Two hundred and sixty-six consecutive patients, each with an acute ischemic cerebrovascular disease, were evaluated within 24 h of symptom onset. We divided our patients into two groups; 1 – Independent (Rankin scale RS ≤ 2) and, 2 – Dependent (RS>3) and death. Baseline characteristics, clinical variables, risk factors, infarct subtypes and radiologic parameters were analyzed. Results– Canadian Neurological Scale (CNS) on admission <6.5 [odds ratio (OR) 22] and posterior circulation infarction (OR 4.2) were associated with a poor outcome at discharge from hospital whereas only a CNS score <6.5 (OR 14) was associated with a poor outcome at 6 months. Conclusions– Severity of neurologic deficit is the most important indicator for clinical outcome in acute ischemic stroke both at short-term and at sixth month, whereas posterior circulation infarction also predicts a poor outcome at discharge.

The effect of gold clusters on the autoxidation of poly(3-hydroxy 10-undecenoate-co-3-hydroxy octanoate) and tissue response evaluation

Abstract: We describe the synthesis and characterization of gold clusters embedded into poly (3-hydroxy octanoate-co-3-hydroxy-10-undecenoate) (PHOU), and evaluated the tissue response of the material upon implantation onto muscle tissue (rat). For this aim, PHOU was obtained by Pseudomonas oleovorans from octanoic acid (OA) and 10-undecenoic acid (UA) with a weight ratio of 50:50. The unsaturated co-polyester film in which HAuCl4 was dispersed was exposed to air at room temperature to produce gold clusters embedded into cross-linked PHOU. The cross-linking kinetics of the gold catalyzed PHOU autoxidation was followed by sol-gel analysis. In vivo tissue reactions of the cross-linked PHOU embedded gold clusters were evaluated by subcutaneous implantation in rats. The rats appeared to be healthy throughout the implantation period. No symptom such as necrosis, abscess or tumor genesis was observed in the vicinity of the implants. Retrieved materials varied in their physical appearance after 6 weeks of implantation. AFM and SEM micrographs of the PHOU containing gold clusters were also taken.

Can Plateletcrit be a Marker for Recurrent Pregnancy Loss

Abstract: Aim:To determine the utility of platelet (PLT) indices for the prediction of recurrent pregnancy loss (RPL).Methods:In all, 208 patients who experienced 2 or more first trimester spontaneous abortions and 95 controls who had no abortions were studied. The hematological markers, including plateletcrit (PCT) and neutrophil (Neu) to lymphocyte (Lym) ratio (NLR), were measured. Thrombophilia genetic tests for factor V Leiden mutation, prothrombin G202I0A mutation, and methylenetetrahydrofolate reductase C677 T and A1298C mutations were performed.Results:The PLT count, PCT, white blood cell count, red cell distribution width (RDW), Lym and Neu count, and NLR were significantly higher in patients with RPL than in controls. The RDW, PLT, and PCT values were higher in the low-risk group, whereas mean PLT volume values were lower than the high-risk group values.Conclusion:Plateletcrit is a low-cost, widely available marker for prediction of RPL in patients with a history of at least 1 abortus.

Error Probability Analysis of NOMA-based Diamond Relaying Network

Abstract: Non-orthogonal multiple access (NOMA)-based cooperative relaying systems (CRS) are very promising to overcome spectral inefficiency of conventional cooperative communications. Although NOMA-CRS have great recent attention, almost all studies investigate NOMA-CRS only in terms of capacity and outage probability. Error performances of NOMA-CRS have not been well-studied. In this paper, we analyze error performance of NOMA-based diamond relaying network (NOMA-DRN) with imperfect successive interference canceler (SIC) as a NOMA-CRS scheme. We derive exact bit error probability (BEP) for NOMA-DRN and provide a tight approximated BEP in the closed-form. In addition, high-SNR analysis is conducted to present that NOMA-DRN has an error floor. Moreover, it is proved that NOMA-DRN turns out to be a non-equiprobable communication system and we derive priori probabilities of symbols. All derived expressions are validated via computer simulations.

Effect of continuous positive airway pressure (CPAP) therapy on IL-23 in patients with obstructive sleep apnea.

Abstract: Obstructive sleep apnea syndrome (OSAS) is a common sleep disorder characterized by repeated episodes of apnea and hypopnea during sleep. Continuous positive airway pressure (CPAP) is the most effective method for treating OSAS and alleviating the patients’ symptoms. The aim of this study was to assess the effect of 3-month CPAP therapy on serum levels of IL-23 in patients with OSAS. Twenty-three patients with newly diagnosed moderate-to-severe OSAS who had not yet started nasal CPAP treatment were prospectively enrolled. All of the subjects underwent simple spirometry and an overnight sleep study. Twenty-seven healthy individuals without OSAS were also recruited as the control group. Serum IL-23 and C-reactive protein (CRP) levels were measured before and after 3 months of CPAP therapy. There was no significant difference between moderate and severe OSAS patients in IL-23 and CRP, but both parameters were significantly higher than control group. The CPAP treatment produced a significant decrease in the levels of the inflammatory mediators CRP and IL-23 in patients. Changes in IL-23 were positively correlated with changes in AHI and in CRP. In conclusion, based on these results, serum IL-23 levels reflect OSAS-related systemic inflammation and are a useful marker for improvement in OSAS following CPAP therapy.