Zonguldak Karaelmas University

About: Zonguldak Karaelmas University is a based out in . It is known for research contribution in the topics: Population & Copolymer. The organization has 1939 authors who have published 4296 publications receiving 62466 citations.

Risperidone and liver function tests in children and adolescents: a short-term prospective study.

Abstract: Objective Revealing of unknown adverse effects of atypical antipsychotics on pediatric population may take a long period of time The purpose of this prospective study is to document changes in the liver function tests (LFTs) associated with risperidone usage in a group of children and adolescents Method Study subjects consist of 120 youths with ages ranging from 3–17 years For this study, patients' baseline and follow-up weight and hepatobiliary function tests including alanine aminotransferases(ALT) and aspartat aminotransferases (AST), gamma gluatamyl transerase (GGT), alkaline phosphatase (ALP) and serum bilirubin levels were measured before and after the treatment period of one month Results Only one male patient's ALT levels increased up to three-fold and AST levels increased up to two-fold of the basal levels First month mean levels of liver enzymes and billuribin of the patients were significantly higher than the baseline Sixty-three patients (525%) showed an asymptomatic increase in the liver enzymes and/or billuribin levels of the first month of this study Weight gain was observed in 58 patients (574%) There was no significant association between changes in weight and liver enzymes and billuribin levels Conclusion We found clinically non significant liver function test abnormalities mostly in the form of ALP elevation in 525% and marked liver enzymes elevation in 08% of risperidone-treated subjects However use of concomitant medications and variations in age are the limitations of this study These findings suggest that risperidone treatment in the short term may lead to liver function changes in children and adolescents

Radioactivity measurements and radiation dose assessments due to natural radiation in Karabuk (Turkey)

Abstract: In this work, the radionuclide activity concentrations of 226Ra, 232Th and 40K in surface soils and radon levels in dwellings of Karabuk, Turkey were determined in order to evaluate the environmental radioactivity Concentrations of 226Ra, 232Th and 40K radionuclides were determined using gamma spectrometry with using HPGe detector The etch track detectors (CR-39) were used to determine the distribution of radon concentrations The average activity concentrations for 226Ra, 232Th and 40K were found as 210, 235 and 3635 Bq kg−1, respectively The calculated average annual effective dose equivalent from the outdoor terrestrial gamma radiation from 226Ra, 232Th and 40K is 535 μSv y−1 The average radon concentration and annual effective dose equivalent of 222Rn in Karabuk dwellings were obtained 1316 Bqm−3 and 332 mSv y−1, respectively The evaluated data were compared with the data obtained from different countries