Zonguldak Karaelmas University

About: Zonguldak Karaelmas University is a based out in . It is known for research contribution in the topics: Population & Copolymer. The organization has 1939 authors who have published 4296 publications receiving 62466 citations.

PART II - HUMAN BODIES TO TEACH ANATOMY: IMPORTANCE AND PROCUREMENT – EXPERIENCE WITH CADAVER DONATION. Parte II - Cuerpos humanos para la enseñanza de la Anatomía: Importancia y procuración – Experiencia con la donación de cadáveres

Abstract: Este Debate fue propuesto para aportar diferentes puntos de vista y conocer la diversidad de circunstancias involucradas en la procuracion y uso de cadaveres para la ensenanza de la Anatomia, a estudiantes de pre y post-grado, en el mundo. Un grupo reducido pero representativo de profesores de Anatomia de todos los continentes fueron invitados a participar. Se distribuyeron algunos lineamientos para que los escritos tuvieran similar orientacion, aunque los autores podian incluir cualquier concepto que consideraran de interes para los lectores. Ademas de los profesores de diversos paises, el Prof. Bernard Moxham (Presidente de IFAA) aporto al Debate la posicion oficial de la Federacion Internacional de Asociaciones de Anatomistas. Los panelistas acordaron en la importancia de utilizar material cadaverico para la ensenanza de la Anatomia, sin embargo, la provision, las fuentes y los procedimientos utilizados para adquirirlos fueron algo diferentes de un pais y/o universidad a otro. La experiencia de los paises europeos, las limitaciones culturales en los asiaticos y africanos, y el retraso y los problemas estructurales en Sudamerica, son algunas de las particularidades que se senalan. Despues de esta publicacion se recibiran las preguntas y comentarios no solo de los participantes sino tambien de los lectores en general, las cuales seran respondidas y ambas, preguntas y respuestas, publicadas en el proximo numero. Entonces, el Debate alcanzara su punto maximo al permitir a todas las personas involucradas en el tema, en cualquier lugar del mundo, participar y aportar informacion adicional. This Debate was proposed to provide different points of view and to know the diversity of circumstances involved in the procurement and use of cadavers to teach Anatomy, to pre and post-graduate students, all over the world. A reduced but representative group of professors of Anatomy of all continents were invited to participate. Some guidelines were distributed to give a common orientation to each paper instead authors were able to include whatever they considered to be of reader’s interest. Within the professors from different countries, Prof. Bernard Moxham (IFAA President) supported the Debate with the International Federation of Associations of Anatomists official position. The panelists agreed about the importance of using cadaveric material to teach Anatomy, but the provision, sources and procedures followed to get them are quite different from one to another country and/or university. The experience of European countries, the cultural limitations in Asiatic and African ones, the delay and structural problems in South America, are some of the pointed peculiarities. After this publication we will receive the questions and comments, not only from the Debate participants but also from general readers, which will be answered and both, questions and answers, published in the next issue. Then, the Debate may reach its top point by letting involved people from all over the world to take part and provide additional information.

The relationship of cerb B 2 expression with estrogen receptor and progesterone receptor and prognostic parameters in endometrial carcinomas

Abstract: Endometrial carcinoma (EC) is the most common malignancy of the female genital tract. Gene alterations and overexpression of various oncogenes are important in tumor development. The human HER 2 neu (c-erbB-2) gene product is a transmembrane receptor with an intracellular tyrosine kinase that plays an important role in coordinating the endometrial growth factor receptor signaling network. The aim of this study was to investigate the expression of c-erbB-2 in endometrial cancer, to study its correlation to established prognostic parameters and estrogen receptor (ER) and progesterone receptor (PR) status. Immunohistochemical (IHC) analyses of ER, PR and c-erbB-2 were performed in 72 EC cases. We detected a positive staining with c erbB 2 in 18.1% of the cases and determined a statistically significant relation between c-erbB-2 and PR. We could not find a statistically significant relation between c-erbB-2 staining and ER. There was not a statistically significant difference between c-erbB-2 and histological grade. The highest level of c-erbB-2 was found in grade 2 cases. There was not any statistically significant relation between c-erbB-2 and menstrual status, myometrial invasion, lymph node status, stage and survival. Although our study provides additional evidence of the potential prognostic role of c-erbB-2, further prospective and controlled studies are required to validate their clinical usefulness.

Synthesis, characterization, and DNA binding of complexes [Pt(bpy)(pip)]2+ and [Pt(bpy)(hpip)]2+

Abstract: Two new platinum(II) complexes, [Pt(bpy)(pip)](NO3)2 (1) and [Pt(bpy)(hpip)](NO3)2·2H2O (2) (bpy is 2,2′-bypyridine; pip is 2-phenylimidazo[4,5-f][1,10]phenanthroline; hpip is 2-(2-hydroxyphenyl) imidazo[4,5-f][1,10]phenanthroline), have been synthesized and fully characterized by CHN analysis, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, 1H-NMR spectroscopy, IR spectroscopy (attenuated total reflection), and UV–vis spectroscopy. The DNA-binding behaviors of both complexes have been studied by spectroscopic methods and viscosity measurements, and their ability to inhibit DNA transcription was measured. The results indicate that both complexes show some degree of binding to DNA in an intercalative mode, resulting in intrinsic binding constants of (2.88 ± 0.4) × 104 and (5.38 ± 0.8) × 104 for 1 and 2, respectively. The comparatively observed difference in the DNA-binding affinities of the two complexes can be reasonably explained by the presence of intramolecular hydrogen bonding between the ortho phenolic group and the nitrogen atom of the imidazole ring. The extended coplanarity of the hpip ligand due to intramolecular hydrogen bonding may lead to an enhancement of the DNA-binding affinity of the hpip complex. In addition, the complexes can promote photocleavage of pUC19 DNA on irradiation as revealed by the spectroscopic and viscometric measurements, with 2 promoting cleavage of pUC19 DNA at lower concentration. Moreover, increasing concentrations of both complexes inhibited DNA transcription, and as expected 2 was shown to be a better antitumor agent than 1.