Granule enzymes of polymorphonuclear neutrophils: A phylogenetic comparison
PG Rausch,TG Moore +1 more
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TLDR
A phylogenetic comparison of enzyme levels in animal and human PMN was undertaken; marked interspecies differences in enzyme activity were found; many species were deficient in alkaline phosphatase or lysozyme.About:
This article is published in Blood.The article was published on 1975-12-01 and is currently open access. It has received 192 citations till now. The article focuses on the topics: Alkaline phosphatase & Lysozyme.read more
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A rapid, direct assay to measure degranulation of bovine neutrophil primary granules.
Mark J. Quade,James A. Roth +1 more
TL;DR: A direct, rapid, quantitative colorimetric assay to determine neutrophil primary granule degranulation was adapted for use with bovine neutrophils and demonstrates that the assay is capable of detecting important differences that may occur in de Granule exocytosis and in total neutrophIL myeloperoxidase content.
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Myeloperoxidase: a front-line defender against phagocytosed microorganisms
Seymour J. Klebanoff,Anthony J. Kettle,Henry Rosen,Christine C. Winterbourn,William M. Nauseef +4 more
TL;DR: Evidence is presented in support of MPO as a major arm of oxidative killing by neutrophils and it is proposed that the essential contribution ofMPO to normal innate host defense is manifest only when exposure to pathogens overwhelms the capacity of other host defense mechanisms.
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Myeloperoxidase: Its role for host defense, inflammation, and neutrophil function
TL;DR: Recent studies using animal models of various inflammatory diseases have demonstrated that MPO deficiency results in the exaggeration of inflammatory response, and that it affects neutrophil functions including cytokine production.
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The bovine neutrophil: Structure and function in blood and milk.
TL;DR: In this article, the mammary gland migration of polymorphonuclear neutrophil leukocytes (PMN) provides the first line of defense against invading mastitis pathogens, but the life span of PMN is limited by the onset of programmed cell death known as apoptosis.
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Myeloperoxidase: Molecular Mechanisms of Action and Their Relevance to Human Health and Disease
TL;DR: The knowledge pertaining to the biologic role of MPO and its downstream effects and mechanisms of action in health and disease is reviewed and discussed.
References
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Serum and urinary lysozyme (muramidase) in monocytic and monomyelocytic leukemia
TL;DR: Present evidence indicates that ly sozyme is the principal, if not the sole, product of the proliferating monocytes in monocytic and monomyelocytic leukemia, and quantitation of serum and urine lysozyme should be a useful diagnostic procedure for these leukemias.
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Brief Report: Simplified Myeloperoxidase Stain Using Benzidine Dihydrochloride
Leonard S. Kaplow,Charlotte Ladd +1 more
TL;DR: A method is described for demonstrating leukocyte peroxidase activity in which benzidine dihydrochloride is used as the indicator compound instead of the more commonly used but potentially more hazardous benzidine base.
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Iodination of bacteria: a bactericidal mechanism
TL;DR: Iodination of the bacteria by the myeloperoxidase-iodide-H2O2 system was demonstrated chemically and radioautographically and suggests the involvement of labile intermediates of iodide oxidation rather than the more stable end products of oxidation such as iodine.
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Leukocyte myeloperoxidase deficiency and disseminated candidiasis: the role of myeloperoxidase in resistance to Candida infection
Robert I. Lehrer,Martin J. Cline +1 more