Showing papers in "Blood Pressure in 2018"
University College London1, University of Milano-Bicocca2, Utrecht University3, University of Brescia4, Paris Descartes University5, University Hospital of Lausanne6, Ghent University7, University of Barcelona8, University of Glasgow9, Karolinska Institutet10, Saarland University11, University of Valencia12, University of Milan13, Oslo University Hospital14, Charité15, University of Birmingham16, Gdańsk Medical University17, University of Zurich18, National and Kapodistrian University of Athens19
TL;DR: These practice guidelines on the management of arterial hypertension are a concise summary of the more extensive ones prepared by the Task Force jointly appointed by the European Society of Hypertension and theEuropean Society of Cardiology.
Abstract: These practice guidelines on the management of arterial hypertension are a concise summary of the more extensive ones prepared by the Task Force jointly appointed by the European Society of Hypertension and the European Society of Cardiology. These guidelines have been prepared on the basis of the best available evidence on all issues deserving recommendations; their role must be educational and not prescriptive or coercive for the management of individual subjects who may differ widely in their personal, medical and cultural characteristics. The members of the Task Force have participated independently in the preparation of these guidelines, drawing on their academic and clinical experience and by objective examination and interpretation of all available literature. A disclosure of their potential conflict of interest is reported on the websites of the ESH and the ESC.
270 citations
TL;DR: The Systolic Blood Pressure Intervention Trial (SPRINT) tested the hypothesis that intensive blood pressure control to a systolic BP target <120 mm Hg would reduce cardiovascular disease outco...
Abstract: The Systolic Blood Pressure Intervention Trial (SPRINT) tested the hypothesis that intensive blood pressure (BP) control to a systolic BP target <120 mm Hg would reduce cardiovascular disease outco...
42 citations
TL;DR: Hemodynamic effects of this beat-to-beat variation in blood pressure may negatively affect vascular structure and function, which may contribute to the increased cardiovascular morbidity and mortality seen in patients with atrial fibrillation.
Abstract: Purpose: Atrial fibrillation (AF) is associated with an increased risk for cardiovascular morbidity and mortality, not entirely explained by thromboembolism. The underlying mechanisms for this association are largely unknown. Similarly, high blood pressure (BP) increases the risk for cardiovascular events. Despite this the interplay between AF and BP is insufficiently studied. The purpose of this study was to examine and quantify the beat-to-beat blood pressure variability in patients with AF in comparison to a control group of patients with sinus rhythm.Materials and methods: We studied 33 patients - 21 in atrial fibrillation and 12 in sinus rhythm - undergoing routine coronary angiography. Invasive blood pressure was recorded at three locations: radial artery, brachial artery and ascending aorta. Blood pressure variability, defined as average beat-to-beat blood pressure difference, was calculated for systolic and diastolic blood pressure at each site.Results: We observed a significant difference...
36 citations
TL;DR: This issue of Blood Pressure proudly presents the 2018 Practice Guidelines for the Management of Arterial Hypertension, a paper developed by the ESH Writing Task Force for the management of Artership, exclusively for Blood Pressure and Journal of Hypertensions, and endorsed byThe ESH.
Abstract: The European Society of Hypertension (ESH) and the European Society of Cardiology (ESC) have jointly issued hypertension guidelines for more than 15 years. The first version was published in June 2...
35 citations
TL;DR: The accelerated arterial aging in treated hypertensive subjects is in large measure explained by age and BP values.
Abstract: Objective: The role of risk factors on the progression of arterial stiffness has not yet been extensively evaluated. The aim of the current longitudinal study was to evaluate the determinants of th...
32 citations
TL;DR: Cutting readings widened the SD of the systolic/diastolic differences between full (reference) and selected recordings and yielded ABP levels similar to recordings including the guideline-recommended ≥20/≥7 readings.
Abstract: Background: Guidelines on the required number of ambulatory blood pressure (ABP) readings focus on individual patients. Clinical researchers often face the dilemma of applying recommendatio...
26 citations
TL;DR: It is expected to prove that clarithromycin allows identification of mutated APA before adrenalectomy and sequencing of tumour DNA and the acute changes of plasma aldosterone concentration, direct active renin concentration, and blood pressure in peripheral venous blood after roxithsromycin can be a proxy for the presence of an APA with somatic mutations.
Abstract: Purpose: Aldosterone-producing adenoma (APA) is the main curable cause of endocrine hypertension cause of primary aldosteronism (PA) and it is in up to 66% of all cases investigated with adrenal vein sampling (AVS). Mutations in the KCNJ5 potassium channel involve up to 70% of APA and cause the most florid PA phenotypes. The recent finding that macrolide antibiotics specifically inhibit in vitro the altered function of mutated KCNJ5 channels has opened new horizons for the diagnosis and treatment of APA with KCNJ5 mutations in that it can allow identification and target treatment of PA patients harbouring a mutated APA. Thus, we aimed at investigating if clarithromycin and roxithromycin, two macrolides that potently blunt mutated Kir3.4 channel function in vitro, affect plasma aldosterone concentration in adrenal vein blood during AVS and in peripheral blood, respectively, in PA patients with a mutated APA.Methods and design: We designed two proof of concept studies. In study A: consecutive patien...
23 citations
TL;DR: RNS can be potentially used to map nerve bundles and guide selectiveAblation of sympathetic nerve fibers and prevent inadvertent ablation of parasympathetic nerve tissue during RDN.
Abstract: Purpose Recently we reported the use of renal nerve stimulation (RNS) during renal denervation (RDN) procedures. RNS induced changes in blood pressure (BP) and heart rate are not fully delineated yet. We hypothesized that electrical stimulation of the sympathetic nerve tissue in the renal artery would lead to an increase in BP and vagal stimulation would cause a decrease in BP. We report the different patterns of BP and heart rate responses elicited by RNS prior to RDN. Methods 35 patients with drug-resistant hypertension were included. RNS was performed under general anesthesia at four sites in the right and left renal arteries, both before and immediately after RDN. RNS-induced BP and heart rate changes were monitored. Results A total of 289 RNS sites in 35 patients were analyzed. An increase in systolic BP of >10 mmHg was regarded as a positive BP response to RNS. This pattern of response was observed in 180 sites (62%). 86 RNS sites (30%) showed an indifferent response with BP changes ≤10 mmHg. At 13 sites (4.5%) RNS elicited a decrease in BP up to -8 mmHg. However, 10 RNS sites (3.5%) showed a pronounced vagal response with hypotension and sinus cycle lengths ranging between 4224-10272 milliseconds. These sites were distributed among two patients. Conclusion RNS identified sympathetic and parasympathetic nerve tissue in the renal arteries. RNS can be potentially used to map nerve bundles and guide selective ablation of sympathetic nerve fibers and prevent inadvertent ablation of parasympathetic nerve tissue during RDN.
21 citations
TL;DR: Compared to uAutoOBP, attended BP measurement gives higher values, both when measured with auscultatory or oscillometric method, while in the highest BP group, they were higher.
Abstract: Aims: Unattended automated office blood pressure (uAutoOBP) may eliminate white-coat effect. In the present study, we studied its relationships to attended office blood pressure (BP) and am...
21 citations
TL;DR: BP measurement using the two arm oscillometric devices achieved a high reliability for SBP, and the agreement with invasive arterial blood pressure in AF patients was moderate.
Abstract: Background: The use of automated (oscillometric) blood pressure (BP) devices is not validated in atrial fibrillation (AF) patients.Objectives: To assess the reliability of three oscillometric BP de...
19 citations
TL;DR: In patients with apparent treatment-resistant hypertension, poor adherence is frequent but does not entirely account for treatment resistance, and psychological characteristics appear as strong predictors of both drug adherence and drug resistance.
Abstract: Purpose: Patients with apparent treatment-resistant hypertension (a-TRH) are often poorly adherent to drug treatment and have an unusual personal history and psychological profile. The aim of this study was to identify predictors of drug adherence and drug resistance in a cohort of patients with aTRH, with emphasis on psychological characteristics.Methods: All patients with confirmed aTRH on standardized antihypertensive treatment were eligible. Drug adherence was assessed by drug dosages in urine using Liquid Chromatography coupled with tandem Mass Spectrometry (LC-MS/MS). Drug resistance was assessed by 24-hour ambulatory blood pressure adjusted for the number of antihypertensive drugs and for drug adherence. Psychological profile was assessed using a broad array of validated questionnaires.Results: The analysis included 35 consecutive patients. The proportion of adherent, partly adherent and totally non-adherent patients was 29, 40 and 31%, respectively. In regression analysis, independent pred...
TL;DR: The new 2017 High Blood Pressure Clinical Practice Guidelines produced by the American College of Cardiology (ACC) and the AHA in collaboration with many other societies were presented provide major conceptual changes when compared to all previously published guidelines.
Abstract: Publication of a new guideline for the prevention, diagnosis and management of hypertension always generates huge interest among general physicians as well as hypertension specialists. In the last 10 years, American and European hypertension guidelines have become increasingly congruent on almost all aspects, including the definition of hypertension stages, therapeutic targets and therapeutic strategies to achieve blood pressure (BP) goals. This was a major advance as physicians and scientists used the same taxonomy and references to handle their patients with hypertension. At the last meeting of the American Heart Association (AHA) in November, the new 2017 High Blood Pressure Clinical Practice Guidelines produced by the American College of Cardiology (ACC) and the AHA in collaboration with many other societies were presented [1]. These recommendations provide major conceptual changes when compared to all previously published guidelines, including JNC7 [2], the 2014 JNC8 committee report [3] and the 2013 European Society of Hypertension(ESH)/European Society of Cardiology (ESC) hypertension guidelines [4]. It is beyond the scope of this editorial to discuss all the differences between the 2017 AHA/ACC guideline and previous ones. However, a few important paradigm shifts deserve comments. These include: (1) the new definition of hypertension, which affects the prevalence of hypertension and its various phenotypes in the population, (2) the lower BP thresholds to start treating hypertension with drugs in high cardiovascular risk patients and (3) the lower BP goals for treated hypertensive patients.
TL;DR: Male sex was positively associated with white-coat hypertension in these adolescents while BMI was positive associated with both white-coated and sustained hypertension.
Abstract: Purpose: Population-based studies estimating prevalence’s of white-coat, masked and sustained hypertension in non-European adolescents are needed, particularly in developing countries. Aiming to determine these estimates and, additionally identify factors associated to these conditions this study was conducted.Materials and methods: Cross-sectional study with a representative sample of secondary school students from a Brazilian state capital. Office measurements were performed with validated semi-automatic devices. Home BP (blood pressure) monitoring protocol included two day-time and two evening-time measurements over 6 days. Adolescents’ were classified as: normotensives (office and home BP <95th percentile); sustained hypertensives (office and home BP ≥95th percentile); white-coat hypertensives (office BP ≥95th percentile and home BP <95th percentile) and masked hypertensives (office BP <95th percentile and home BP ≥95th percentile). Logistic regression models were built to identify if sex, age...
TL;DR: The familial aggregation of EH among first degree relatives of children with EH was identified with an increased liability of childhood onset EH with parental EH, and prediction for childhood-onset EH is improved by obtaining a family history of Eh in the firstdegree relatives.
Abstract: Purpose: Determining familial aggregation is an important first step in narrowing the search for disease-causing genes and hence we determined the familial aggregation of EH among first degree rela...
TL;DR: It is hypothesized that inflammatory bowel disease patients with chronic, systemic inflammation have an increased arterial stiffness associated with the disease duration, and chronic subclinical inflammation is responsible for dyslipidemia and accelerated atherosclerosis which consequently alterates arterial elasticity.
Abstract: Purpose: Chronic inflammatory diseases are related with earlier onset of atherosclerosis. We hypothesized that inflammatory bowel disease patients with chronic, systemic inflammation have an increased arterial stiffness associated with the disease duration. Also, we wanted to compare arterial stiffness markers between inflammatory bowel disease and well-controlled hypertension patients.Materials and methods: A total of 89 inflammatory bowel disease patients (60 patients with Crohn’s disease and 29 patients with ulcerative colitis, age range 20–64 years) without history of arterial hypertension or diabetes were enrolled and age matched with a control group of patients (73 patients, age range 25–69 years, 41 (56.1%) males) with known history of well-controlled arterial hypertension. We have used a noninvasive device that simultaneously measures brachial blood pressure and estimates PWV and AIx in inflammatory bowel disease and hypertension groups of patients.Results: Patients with pathological PWV v...
TL;DR: The data showed an increasedretinal vascular resistance in hypertensive patients compared to non-hypertensive patients prior to the occurrence of structural retinal vascular remodeling in early hypertension.
Abstract: Purpose: Retinal microcirculation represents an easily accessible, non-invasive, in-vivo possibility to assess early microvascular changes. In addition to the assessment of functional (e.g. retinal...
TL;DR: A summary of the principle methods used to perform a cost-effectiveness analysis of renal denervation, using the DENERHTN results as an example, is provided.
Abstract: Whilst much uncertainty exists as to the efficacy of renal denervation (RDN), the positive results of the DENERHTN study in France confirmed the interest of an economic evaluation in order to assess efficiency of RDN and inform local decision makers about the costs and benefits of this intervention. The uncertainty surrounding both the outcomes and the costs can be described using health economic methods such as the non-parametric bootstrap. Internationally, numerous health economic studies using a cost-effectiveness model to assess the impact of RDN in terms of cost and effectiveness compared to antihypertensive medical treatment have been conducted. The DENERHTN cost-effectiveness study was the first health economic evaluation specifically designed to assess the cost-effectiveness of RDN using individual data. Using the DENERHTN results as an example, we provide here a summary of the principle methods used to perform a cost-effectiveness analysis.
TL;DR: Body mass index is the most important predictor of BP, followed by low socioeconomic status, which means at-risk children may be suitable for screening and intervention studies.
Abstract: Purpose To determine the prevalence of hypertension and predictors of blood pressure (BP) in a population based survey of Australian children. Subjects and methods We analysed cross-sectional data for 2071 children, aged 5-17 years, from the Australian Health Survey 2011-13. Hypertension and high-normal BP were defined by a systolic or diastolic BP greater than the 95th and 90th centiles respectively, using the National High Blood Pressure Education Program fourth report reference data. We also examined the association of several predictor variables (age, sex, remoteness, socioeconomic status, body mass index) with BP as a continuous variable. Results A total of 5.8% (95%CI 4.4-7.2) of children had hypertension, and a further 6.8% (95%CI 5.4-8.3) had high-normal BP. The strongest predictor of BP was body mass index. After adjustment, children in the overweight and obese categories had a BP that was on average 4 (95%CI 2-6) and 8 mmHg (95%CI 6-11) higher than those of normal weight. Socio-economic status was a statistically significant predictor of BP, but the effect size was more modest (2 mmHg [95%CI 0-4] between the highest and lowest tertile). Conclusions Hypertension or high-normal BP is present in 12.6% of Australian children. Body mass index is the most important predictor of BP, followed by low socioeconomic status. These at-risk children may be suitable for screening and intervention studies.
TL;DR: In normotensive and normoglycemic healthy subjects, the evaluated biomarkers of atherosclerotic process didn’t show any significant association with cardiac, carotid and vascular TOD while age and BP are its principal predictors.
Abstract: Purpose: Only few studies evaluated biomarkers useful for defining the cardiovascular risk of a subject in a pre-clinical condition (i.e. healthy subjects). In this context we sought to determine the relationships of Plasminogen activator inhibitor type 1 (PAI‐1), P-Selectin, Tissue Inhibitors Metalloproteinases type 1 (TIMP-1) and Cystatin-C with subclinical Target Organ Damage (TOD) in normotensive and normoglycemic subjects without known cardiovascular and kidney diseases.Materials and Methods: 480 blood donors participated at the present analysis. TOD was evaluated as Pulse Wave Velocity (PWV), Left Ventricular Hypertrophy (LVH) and Intima Media Thickness (IMT) and carotid plaque presence) grouped together under carotid TOD.Results: 3.1% of the subjects showed a PWV higher than 10 m/sec with those subjects exerting significantly lower values of P-Selectine (0.068 ± 0.015 vs 0.08 ± 0.036 mg/L, p = .014). 8.8% of the subjects showed carotid TOD that was associated with higher Cystatin-C values (...
TL;DR: The study shows that uAutoOBP is not good predictor of ambulatory blood pressure monitoring, not even of the daytime values, and might, however, indicate short-term blood pressure variability and, when compared with AuscOBP, also detect patients with white-coat effect.
Abstract: Aims: Several papers reported that unattended automated office blood pressure (uAutoOBP) is closely related to daytime ambulatory blood pressure monitoring (ABPM). In the present study, we aim to study uAutoOBP and its relation to 24-hour ABPM and ABPM variability.Material and methods: Stable treated hypertensive subjects were examined in two Czech academic hypertension centres. uAutoOBP was measured with the BP Tru device; attended BP three times with auscultatory method (AuscOBP) by the physician. ABPM was performed within one week from the clinical visit.Results: Data on 98 subjects aged 67.7 ± 9.3 years with 24-hour ABPM 120.3 ± 10.6/72.7 ± 7.9 mm Hg are reported. uAutoOBP was lower than 24-hour (by −5.2 ± 11.3/−0.5 ± 6.9 mm Hg) and daytime (by −6.7 ± 12.82.4 ± 8.0 mm Hg) ABPM and the individual variability of the difference was very large (up to 30 mm Hg). The correlation coefficients between ABPM and uAutoOBP were similar compared to AuscOBP (p ≥ .17). Variability of uAutoOBP, but not AuscOB...
TL;DR: Uncontrolled hypertension was highly prevalent in ischemic stroke survivors <60 years and associated with co-presence of obesity and functional and structural arterial damage.
Abstract: Purpose Hypertension is the most important modifiable risk factor for stroke. Few data are available on control of hypertension in younger ischemic stroke survivors. Material and methods We assessed clinic and ambulatory blood pressure (BP) measurements in 320 patients aged 15-60 years (mean 48 ± 10) included in the Norwegian Stroke in the Young Study during 3-months follow-up after the index stroke. Controlled hypertension was defined as ambulatory BP 1.5 mm. Results At hospital discharge, 58% of the patients were treated for hypertension. Another 9% of the total study population was diagnosed with new-onset hypertension during follow-up. At the 3-months follow-up visit, 56% of patients with treated hypertension were uncontrolled. Patients with uncontrolled treated hypertension were older, had higher body mass index (BMI) and PWV, and were more likely to have diabetes and carotid plaques compared to patients with normotension (p Conclusion Uncontrolled hypertension was highly prevalent in ischemic stroke survivors
TL;DR: The results indicate that, in small resistance arteries of patients with essential hypertension, a relevant fibrosis may be detected; fibronectin and TGF-β1 tunica media content is increased, while laminin and emilin-1 content is decreased; these changes might be involved in the development of small resistance artery remodeling in humans.
Abstract: Background: In the development of hypertensive microvascular remodeling, a relevant role may be played by changes in extracellular matrix proteins. Aim of this study was the to evaluate some extrac...
TL;DR: The feasibility of the Arteriograph to monitor changes in BP and arterial stiffness by treatment is demonstrated and it is demonstrated that blocking the renin-angiotensin system may have additional effects beyond BP reduction.
Abstract: Purpose: Inhibition of the renin-angiotensin system may have effects on vascular structure and function beyond the effects on blood pressure (BP) reduction. We studied the ability of a single arm cuff oscillometric method (Arteriograph, TensioMed, Hungary) to assess effects of antihypertensive treatment on BP and arterial stiffness. Furthermore, this technique was compared to pulse wave analysis and applanation tonometry (SphygmoCor, AtCor Medical, Australia).Materials and methods: Brachial and aortic BP, augmentation index (AIx), and carotid-femoral pulse wave velocity (PWV) was simultaneously assessed by both techniques in 71 untreated hypertensive patients. Thereafter, 58 completed double-blind randomized treatment for 12 weeks with ramipril or doxazosin.Results: Treatment (assessed by the Arteriograph) reduced aortic more than brachial systolic BP (−13.2 vs. −11.2 mm Hg; p = .002) and improved all indices of arterial stiffness. This greater reduction in aortic to brachial systolic BP was more ...
TL;DR: BP measurement using the two arm oscillometric devices (OmronHEM907TM and Microlife WatchBPhome) achieved a high reliability for SBP, and wrist devices are not suitable to measure BP in patients in AF.
Abstract: Hypertension is the most prevalent concomitant condition in patients with atrial fibrillation (AF) [1–3]. Both uncontrolled hypertension and AF are major risk factors for stroke and heart failure [4]. In patients receiving anticoagulant therapy, good control of blood pressure (BP) reduces the bleeding events [5]. Therefore, successful antihypertensive treatment is a cornerstone of AF management [6,7]. Whatever the device, accurate BP measurement always remains challenging in AF patients and particularly so with easy-to-use devices [8]. While automated oscillometric BP measurements have dominated the market, the role of these devices in AF management is still controversial [9]. BP measurement in AF patients is difficult [10], as this arrhythmia is associated with increased beat-to-beat BP variability, reflecting variations in ventricular filling time, stroke volume, and contractility [11]. To address this problem, better understanding of the AF-related hemodynamic alterations resulted in development of a high-accuracy embedded algorithm, which became a useful screening tool for the detection of asymptomatic AF during routine automated BP measurement [12]. Previous studies that assessed automated BP measurements in AF suggest that this method might be more accurate for SBP than DBP measurement [8]. While most AF patients have primarily systolic hypertension, imprecise assessment of DBP is of concern, as too aggressive DBP lowering might result in coronary hypoperfusion and myocardial ischaemia. Furthermore, it has been stressed [11] that published evidence regarding the role of ambulatory blood pressure monitoring (ABPM) in AF patients is scarce. In this issue of Blood Pressure, two original papers address the issue of oscillometric BP measurement in AF. Halfon et al. [13] assessed the reliability of three oscillometric BP devices, and the agreement with invasive arterial blood pressure. MiszkowskaNag orna et al. [14] estimated the accuracy of the oscillometric ABPM device (SpaceLabs 90207) with reference to mercury manometer-based readings. In the Swiss study [13], OmronR7TM wrist device failed to obtain any BP readings. These results are consistent with a previous report [15] indicating that wrist devices are not suitable to measure BP in patients in AF. BP measurement using the two arm oscillometric devices (OmronHEM907TM and Microlife WatchBPhome) achieved a high reliability for SBP. The agreement between intra-arterial and oscillometric measurements was substantially improved when the average of three consecutive measurements was taken into account. In the Polish study [14], diastolic BP tended to be slightly overestimated when assessed with SpaceLabs 90207. In spite of these limitations, the study supports the ESH Working Group statement [11] that there is no reason to exclude AF patients from the ABPM procedures. In conclusion, first, wrist devices should not be used in AF patients. Second, if an automated oscillometric arm device is used, BP should be derived from at least three consecutive measurements. Third, the oscillometric measurement is more reliable for SBP than DBP. In case of doubts regarding DBP level, the physicians should refer to auscultatory method. Fourth, there is no agreed procedure for BP monitor validation in AF. Clearly, further technological improvement, specific validation protocols and larger trials in AF patients are needed, but precise BP measurements will probably remain difficult because of the intrinsic nature of AF. Hopefully, next generation arrhythmia-sensitive BP devices will facilitate future hypertension management and lead to better prevention of cardiovascular events in AF patients.
TL;DR: There is an unexpectedly high prevalence of different forms of diastolic dysfunction in treated hypertensive patients who are free of overt cardiovascular disease, whereas blood-lowering therapy attenuated the risk.
Abstract: Background: Although the presence of sub-clinical left ventricular diastolic dysfunction (LVDD) increases cardiovascular risk, the current ESH/ESC guidelines do not include the presence of this con...
TL;DR: Hypertension care with telemonitoring and telemedicine are expected to require shorter time to achieve HBP control compared to usual care, and combining HBPtelemonitoring with telemedics may lower the hurdles for starting and persisting to hypertension treatment and eventually reduce cardiovascular events.
Abstract: Purpose: Although self-measurement of home blood pressure (HBP) is common in Japan and HBP telemonitoring via the Internet is possible, whether telemonitoring improves HBP control better than conve...
TL;DR: In a Primary Care population with ≥1 cardiovascular risk factors, ILSBPD showed acceptable diagnostic accuracy for PAD, whilst IASBPD accuracy was negligible, and oscillometer ABI seems to be preferable to detect PAD and individuals at high cardiovascular risk.
Abstract: Purpose: Inter-arm systolic blood pressure differences (IASBPD) and inter-leg systolic blood pressure differences (ILSBPD) have arisen as potential tools to detect peripheral artery disease (PAD) a...
TL;DR: Short-term incremental CPAP leads to significant increases in BP and BPV in obese patients with OSA while awake, and careful titration of pressures is required to minimise the risk of nocturnal awakenings while improving BP control.
Abstract: Objectives: Continuous positive airway pressure (CPAP) improves upper airway obstruction in patients with obstructive sleep apnoea (OSA), who often are overweight-obese. Although it is thought that...
TL;DR: Serum osteocalcin level was not independently associated with blood pressure in a Chinese population, and the association disappeared after adjustment for body mass index, waist circumference, blood glucose, and homeostasis model assessment of insulin resistance.
Abstract: Purpose: This observational study investigated the association between serum osteocalcin level and blood pressure in a Chinese population.Materials and methods: A total of 2241 subjects (909 men an...
TL;DR: The direct comparisons of BP readings allowed to conclude that diastolic blood pressure tended to be slightly overestimated when assessed with SpaceLabs 90207 in patients with both, AFib and SR, which was not a case for systolic BP.
Abstract: Purpose: Irregular heart rhythm in the course of atrial fibrillation (AFib) results in lower blood pressure (BP) measurements reproducibility which is further limited by various BP-monitors used. Therefore the aim of our study was to estimate accuracy of oscillometric BP measurement (SpaceLabs 90207) with reference to mercury manometer-based readings.Material and methods: Study was performed in 47 hemodynamically stable patients aged 63 ± 12 yo with paroxysmal or persistent AFib, at baseline. Patients were reassessed within one week after effective cardioversion (SR; n = 29). BP was measured using Y-tube connection allowing for simultaneous measurements on the same arm with SpaceLabs 90207 and referral method. Mean values were tested with paired t-tests. Additionally, concordance correlation coefficient (ρc) and Bland-Altman plots were assessed. Results were confronted with AAMI, and ESH-IP criteria.Results: Both during arrhythmia and sinus rhythm diastolic BP differed significantly (Δ = 4.6 ± 6.0...