Journal ArticleDOI
In healthy normotensive subjects age and blood pressure better predict subclinical vascular and cardiac organ damage than atherosclerosis biomarkers.
Alessandro Maloberti,Francesca Farina,Marco Carbonaro,Enrico Piccinelli,Ilaria Bassi,Francesco Pansera,Guido Grassi,Giuseppe Mancia,Paola Palestini,Cristina Giannattasio +9 more
TLDR
In normotensive and normoglycemic healthy subjects, the evaluated biomarkers of atherosclerotic process didn’t show any significant association with cardiac, carotid and vascular TOD while age and BP are its principal predictors.Abstract:
Purpose: Only few studies evaluated biomarkers useful for defining the cardiovascular risk of a subject in a pre-clinical condition (i.e. healthy subjects). In this context we sought to determine the relationships of Plasminogen activator inhibitor type 1 (PAI‐1), P-Selectin, Tissue Inhibitors Metalloproteinases type 1 (TIMP-1) and Cystatin-C with subclinical Target Organ Damage (TOD) in normotensive and normoglycemic subjects without known cardiovascular and kidney diseases.Materials and Methods: 480 blood donors participated at the present analysis. TOD was evaluated as Pulse Wave Velocity (PWV), Left Ventricular Hypertrophy (LVH) and Intima Media Thickness (IMT) and carotid plaque presence) grouped together under carotid TOD.Results: 3.1% of the subjects showed a PWV higher than 10 m/sec with those subjects exerting significantly lower values of P-Selectine (0.068 ± 0.015 vs 0.08 ± 0.036 mg/L, p = .014). 8.8% of the subjects showed carotid TOD that was associated with higher Cystatin-C values (...read more
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Determinants of pulse wave velocity in healthy people and in the presence of cardiovascular risk factors
TL;DR: This study is the first to establish reference and normal values for PWV, combining a sizeable European population after standardizing results for different methods of PWV measurement.
Journal ArticleDOI
Subclinical atherosclerosis burden predicts cardiovascular events in individuals with diabetes and chronic kidney disease
Ana Palanca,Esmeralda Castelblanco,Angels Betriu,Hèctor Perpiñán,Berta Soldevila,Jose M. Valdivielso,Marcelino Bermúdez-López,Carlos Puig-Jové,Manel Puig-Domingo,Per-Henrik Groop,Elvira Fernández,Núria Alonso,Didac Mauricio +12 more
TL;DR: Early detection of subclinical atherosclerotic burden by multiterritorial vascular ultrasound could improve CVE prediction in this population of individuals with diabetes and chronic kidney disease.
Journal ArticleDOI
Hyperuricemia prevalence in healthy subjects and its relationship with cardiovascular target organ damage.
Alessandro Maloberti,Esmerilda Qualliu,Lucia Occhi,Sun Jinwei,Enzo Grasso,Chiara Tognola,Giovanni Tavecchia,Iside Cartella,Martina Milani,P. Vallerio,Stefano Signorini,Paolo Brambilla,Marco Casati,Michele Bombelli,Guido Grassi,Cristina Giannattasio +15 more
TL;DR: In this specific population UA is significantly associated with renal impairment while this was not the case for cardiac and vascular damage, and its prevalence could further increase if lower cut-off will be used.
Journal ArticleDOI
Role of Heparin-Binding Epidermal Growth Factor-Like Growth Factor in Oxidative Stress-Associated Metabolic Diseases.
TL;DR: Modulations of HB- EGF signaling showed a series of protections against phenotypes related to metabolic syndrome and advanced metabolic diseases, suggesting HB-EGF as a potential target against metabolic diseases.
Journal ArticleDOI
Small, Dense Low-Density Lipoprotein-Cholesterol and Atherosclerosis: Relationship and Therapeutic Strategies
TL;DR: It was found that sdLDL-C can increase the atherogenic effect by regulating the activity of gene networks, monocytes, and enzymes, and drug interventions such as statins, fibrates, ezetimibe, and niacin have also been found to improve sdLDl-C levels.
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Journal ArticleDOI
Determinants of pulse wave velocity in healthy people and in the presence of cardiovascular risk factors: 'establishing normal and reference values'.
Francesco U.S. Mattace-Raso,Albert Hofman,Germaine C. Verwoert,Jacqueline C.M. Witteman,Ian B. Wilkinson,John R. Cockcroft,Carmel M. McEniery,Yasmin,Stéphane Laurent,Pierre Boutouyrie,Erwan Bozec,Tine W. Hansen,Christian Torp-Pedersen,Hans Ibsen,Hans Ibsen,Jørgen Jeppesen,Sebastian Vermeersch,Ernst Rietzschel,Marc De Buyzere,Thierry C. Gillebert,Luc M. Van Bortel,Patrick Segers,Charalambos Vlachopoulos,Constantinos Aznaouridis,Christodoulos Stefanadis,Athanase Benetos,Athanase Benetos,Carlos Labat,Carlos Labat,Patrick Lacolley,Patrick Lacolley,Coen D.A. Stehouwer,Giel Nijpels,Jacqueline M. Dekker,Isabel Ferreira,Jos W. R. Twisk,Sébastien Czernichow,Pilar Galan,Serge Hercberg,Bruno Pannier,Alain P. Guerin,Gérard M. London,John Kennedy Cruickshank,John Kennedy Cruickshank,Simon G. Anderson,Anna Paini,Enrico Agabiti Rosei,Maria Lorenza Muiesan,Massimo Salvetti,Jan Filipovsky,Jitka Seidlerová,M. Dolejšová +51 more
TL;DR: In this paper, the authors established reference and normal values for Carotid-femoral pulse wave velocity (PWV), a direct measure of aortic stiffness, based on a large European population.