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Showing papers in "Computer Methods and Programs in Biomedicine in 1986"


Journal ArticleDOI
TL;DR: This 'minimal modelling approach' fits two mathematical models with FSIGT glucose and insulin data: one of glucose disappearance and one of insulin kinetics, and MINMOD is the computer program which identifies the model parameters for each individual.

725 citations


Journal ArticleDOI
TL;DR: The present program is written in an elementary subset of BASIC and will perform Kruskal-Wallis test followed by multiple comparisons between the groups on practically any computer programmable in BASIC.

329 citations


Journal ArticleDOI
Perry L. Miller1
TL;DR: In this paper, the authors discuss the underlying issues in the evaluation of computer systems which apply artificial intelligence in medicine, including subjective evaluation of the research contribution of a developmental prototype, validation of a system's knowledge and performance, and evaluation of clinical efficacy of an operational system.

47 citations


Journal ArticleDOI
TL;DR: A method for using causal knowledge to structure findings according to their probabilistic dependencies and an inference procedure is discussed which propagates probabilities within a network of causally related findings in order to calculate posterior probabilities of diagnostic hypotheses.

42 citations


Journal ArticleDOI
TL;DR: A BMDP program for obtaining near optimum piecewise linear regression equations and an idea intrinsic to the method is that restricting parameter space to a discrete set makes the difficult problems become standard problems.

41 citations


Journal ArticleDOI
TL;DR: How a large number of programs in current use to fit this model can be easily adapted to incorporate this goodness of fit statistic is indicated.

41 citations


Journal ArticleDOI
TL;DR: A computer program for cycle-by-cycle analysis and quantification of biological rhythms, written for an Apple II microcomputer with 48k RAM is described and analysis of human ventilatory airflow signal is given.

36 citations


Journal ArticleDOI
TL;DR: MULTI-FORTE is an expanded version of the MULTI non-linear fitting programs written by Yamaoka et al. that has been combined and translated into FORTRAN 77 on the Macintosh computer for both speed and convenience.

36 citations


Journal ArticleDOI
TL;DR: A microcomputer program in BASIC for predicting mortality in mice administered metrazol is designed and is fairly accurate and reliable in expressing tolerance of mice as a function of the dose and the time.

28 citations


Journal ArticleDOI
Detlef Hof1
TL;DR: A widely applicable measuring system, especially suited for all types of 'voltage-clamp' (including 'patch-Clamp') experiments, is presented, mainly based on commercially available hardware and software components.

26 citations


Journal ArticleDOI
TL;DR: A program, AQ, has been developed to perform analog-to-digital (A/D) conversions on IBM PC products using the Data Translation DT2801-A orDT2801 boards, written so that a minimum number of keystrokes are required for their operation.

Journal ArticleDOI
TL;DR: The Kalman Filter is one of the most powerful methods for time series analysis and it is shown to be useful in a variety of settings, including the detection of kidney transplant rejection, where detection in some patients precedes that of experienced clinicians.

Journal ArticleDOI
TL;DR: A recently developed device which provides continuous, direct monitoring of the pressure relief performance of persons confined to wheelchairs is reported, and examples of such data are presented.

Journal ArticleDOI
TL;DR: A three-dimensional artificial visual system has been developed to aid in the analysis of 3-D fluorescence images of smooth muscle cells and patterns of organization in the distribution of the protein bodies are investigated using an interactive graphics system.

Journal ArticleDOI
TL;DR: In this paper, the use of computers for critical care data management may markedly increase the volume of digital numbers presented to the nurse and clinician, which may not be optimum for estimating the graded levels of intervention required for specific physiologic problems.

Journal ArticleDOI
TL;DR: A pharmacokinetic program that allows individualization of Factor VIII dosage regiments in hemophilia patients undergoing major surgery is described, which is designed for the IBM PC microcomputer and compatible machines, and is based upon the one-compartment open model with instantaneous input.

Journal ArticleDOI
TL;DR: It is pointed out that computers are well suited for driving the stimulus in tracking tasks as well as recording the performance in experiments based on tracking tasks and on measuring the effects of levodopa therapy on the motor symptoms of Parkinson's disease.

Journal ArticleDOI
TL;DR: A robust estimator of a variance ratio is presented, which gives indications about the functional role of the neuron by analysing the variances of the stimulus-response and response-movement times.

Journal ArticleDOI
TL;DR: A processing program for radioimmunoassay data is described which uses a log/logit transformation and maximum likelihood estimation to describe mathematically the standard curve, providing a chi 2 test of goodness of fit for the model.

Journal ArticleDOI
TL;DR: A data acquisition system is described which acquires data from contracting skeletal muscle while acquiring contractile data in real-time and is applicable to any experimental environment involving data acquisition, storage and analysis.

Journal ArticleDOI
TL;DR: ANSIM uses established modeling techniques to create a life-like anesthesia simulator that is useful as an educational tool for demonstrating classic concepts of uptake and distribution of inhaled anesthetics.

Journal ArticleDOI
TL;DR: The development of an automated system to perform writing of prescriptions and associated advice in a dermatologist's office and efforts to expand its applicability to another ambulatory care setting (gastroenterology) are described.

Journal ArticleDOI
TL;DR: ICON explores the design issues involved in critiquing the process of differential diagnosis, and is currently implemented in a limited domain: the radiographic diagnosis of a lung mass in a patient with Hodgkin's disease.

Journal ArticleDOI
TL;DR: A new, integrated digital signal processing (DSP) system, the Personal Acoustics Lab (PAL), is described, suitable for analogue signal digitization at rates from several samples per hour to 150,000 samples per second in 12- or 16-bit words.

Journal ArticleDOI
TL;DR: The use of a computer program for diagnosing acute abdominal pain in children using Bayes' theorem is described and the results of a one-year trial are analysed in order to qualify and quantify the accuracy of the system and to suggest some of the educational benefits that might be obtained.

Journal ArticleDOI
TL;DR: The authors surveyed diagnosing processes used by physicians to determine what advice physicians want and found that knowledge for diagnosing the above-mentioned disease should be categorized according to four types of rules.

Journal ArticleDOI
TL;DR: Software for analysis of force plate recordings of the horse at normal walk is described, and the data of a number of stance phases are averaged to obtain a representative tracing of that horse.

Journal ArticleDOI
TL;DR: Using a video-image system coupled to a minicomputer with commercial image handling software, autoradiographic grains displayed in dark-field are counted with a fast and reliable grain-recognizing FORTRAN program executed in the users memory.

Journal ArticleDOI
TL;DR: A parallel activation model of reading aloud is being implemented and subjected to experiments based on a theory that competition between cognitive processes for limited neurophysiological resources is a fundamental organizing principle of memory retrieval.

Journal ArticleDOI
TL;DR: Various algorithms for the detection of QRS complexes, atrial and artefacts are described and used in various of the TNO Modular ECG/VCG Interpretation Systems including its lates version, MEANS.