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Showing papers in "Contraception in 2000"


Journal ArticleDOI
TL;DR: Based on the biochemical and pharmacodynamic data, drospirenone appears to be a viable alternative to the currently available progestogens.

347 citations


Journal ArticleDOI
TL;DR: Low-dose mifepristone 200 mg and home administration of vaginal misoprostol 800 microg at 48 h were highly effective and acceptable to women < or =63 days pregnant, thereby expanding the number of women who can access a medical abortion.

173 citations


Journal ArticleDOI
TL;DR: Yasmin is an effective oral contraceptive that is safe and well tolerated and the impact of the new progestogen DRSP on the women's self-perception of menstrual health was also evaluated.

169 citations


Journal ArticleDOI
TL;DR: The level of evidence supporting a positive association between OC use and increased BMD is II-1, and suggestions for a study design that could yield Level I evidence are made.

114 citations


Journal ArticleDOI
TL;DR: Women who may derive particular benefit from reduced menstrual frequency include not only those with medical conditions directly caused or aggravated by menses, but also those serving in the military, female athletes, mentally-retarded women with menstrual hygiene problems, young teens, and perimenopausal women.

103 citations


Journal ArticleDOI
TL;DR: It is concluded that both mifepristone and methotrexate, when administered with misoprostol, have high levels of success at < or =49 days gestation but may have lower efficacy at longer gestation.

102 citations


Journal ArticleDOI
TL;DR: The rheological properties of 4 commercially available contraceptive drug delivery gels and their dilutions with a vaginal fluid simulant were measured, and all gels exhibited non-Newtonian behavior including shear thinning and viscoelasticity.

100 citations


Journal ArticleDOI
TL;DR: A review of the rapidly growing but geographically lopsided literature on emergency contraception can be found in this paper, with a focus on the social science and service delivery aspects of emergency contraception.

99 citations


Journal ArticleDOI
TL;DR: In women who did not have a strong preference between medical and surgical abortion, the side effect profile and patient acceptability was significantly better for surgical abortion compared to medical abortion.

97 citations


Journal ArticleDOI
TL;DR: In this paper, the authors evaluated the effect of long-term use of the injectable contraceptive depot medroxyprogesterone acetate (DMPA) on human vaginal histology.

86 citations


Journal ArticleDOI
TL;DR: It is concluded that Implanon did not change the volume and composition of breast milk and the low concentration of etonogestrel ingested by the infant was not associated with adverse effects.

Journal ArticleDOI
TL;DR: It is concluded that therectal use of N-9-containing products causes a rapid exfoliation of extensive areas of the rectal epithelium, which would render a person more at risk for infection by HIV and other sexually transmitted pathogens.

Journal ArticleDOI
TL;DR: Data obtained suggest that casein microspheres would be promising as a biodegradable drug carrier for sustained delivery of steroids.

Journal ArticleDOI
TL;DR: Multiparous women should receive increased education given their lack of knowledge but willingness to use emergency contraception, and educational efforts must include accurate information about its mechanism of use and safety.

Journal ArticleDOI
TL;DR: T implants provide adequate spermatogenic suppression in approximately 70% of Caucasian men, a rate comparable to intramuscular T injections but with minimal side effects; and, the inclusion of a type 2 5alpha-reductase inhibitor does not enhance sperMatogenic suppression.

Journal ArticleDOI
TL;DR: The copper corrosion and product layers originating in a simulated uterine solution at pH values 6.3 and 8.0 for 15, 65, 180, and 360 days at 37 degrees C were studied and the main compounds identified were cuprite (Cu(2)O), calcite (CaCO(3)), and phosphates.

Journal ArticleDOI
TL;DR: In this paper, the antiprogesterone mifepristone and gemeprost were combined with prostaglandin to induce abortion in early pregnancy up to 63 days of gestation.

Journal ArticleDOI
TL;DR: The contraceptive effect of the extract of the leaf-stalk of Piper betle linn is mainly on the maturation process of spermatozoa in epididymides without influencing hystemic hormonal profiles.

Journal ArticleDOI
TL;DR: EC users were older, better educated, more often in stable relationships, had experienced more abortions, and gestation age was less, however, younger women were in general better informed of EC.

Journal ArticleDOI
TL;DR: A population-based prospective study with women aged 18-39 years old enrolled at a health maintenance organization found an association between DMPA use and depressive symptoms but further research is needed to determine whether the relationship is causal.

Journal ArticleDOI
TL;DR: Gossypol blood levels indicated that sperm suppression occurs independently of concentration, whereas spermatogenesis recovery appears to be concentration-dependent, which may help this compound become a medical alternative to surgical vasectomy when the delay in onset of infertility is acceptable.

Journal ArticleDOI
TL;DR: The data from this 3-year, ongoing study demonstrate that the shortcomings of the inserter have been corrected, resulting in better performance and a much reduced rate of failed insertion/expulsion of the frameless and anchored device.

Journal ArticleDOI
TL;DR: In this paper, the authors investigated the association between weight gain and Depo-medroxyprogesterone acetate (DMPA) in Navajo women and quantified the magnitude of weight gain.

Journal ArticleDOI
TL;DR: In this paper, the effect of oral contraceptive (OC) use on vaginal discharge, epithelium, and flora was examined in 30 women who planned to use OC for contraception and 2 months after the start of OC use.

Journal ArticleDOI
TL;DR: The present longitudinal cohort study on 59 Chinese women over a period of 3 years has shown that their annual rate of bone loss was substantially less than the projected values and suggested a retardation in bone loss with time and potentially due to the effect of progesterone in decreasing bone turnover that is similar to the situation in postmenopausal women.

Journal ArticleDOI
TL;DR: The boom and bust phenomenon goes to the heart of what some have referred to as the failed promise of the contraception revolution by creating obstacles to significant expansion of contraceptive choice in the United States.

Journal ArticleDOI
TL;DR: Women are able to use LAM effectively without extensive counseling or follow-up, with a high level of user satisfaction, and under conditions of limited client-provider contact, LAM remains effective and leads to acceptance of another method by about two-thirds of the acceptors.

Journal ArticleDOI
TL;DR: The objective of this study was to compare sexually transmitted disease (STD) occurrence and STD complaints in women using intrauterine device (IUD) with women who are not using any modern contraceptive method in a family planning setting in Trabzon, Turkey.

Journal ArticleDOI
TL;DR: For continuing implant users, annual pregnancy rates <1.0/100 in years 6 and 7, together with low cumulative pregnancy rates, testify that Norplant capsule implants remain highly effective for 7 years.

Journal ArticleDOI
TL;DR: The human amnious WISH cell line was employed as a model of uterine cells in the presence of copper, and the cell viability was decreased by elemental copper, which was alleviated up to 70% by the addition of catalase.